Prospects of NIR fluorescent nanosensors for green detection of SARS-CoV-2

Li, Dan; Zhou, Zipeng; Sun, Jiachen; Mei, Xifan

doi:10.1016/j.snb.2022.131764

Cited by 13 publications

(5 citation statements)

References 132 publications

(124 reference statements)

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“…Although fluorescence sensors offer a straightforward analytical approach, autofluorescence from biological samples can lead to inaccurate results because of the interferences. Fluorescence near-infrared (NIR) nanosensors, made from low-toxic materials to facilitate greener diagnostics, as introduced in [ 252 ], can lower background signals significantly. While still in its early stages, this research holds promise for sustainable SARS-CoV-2 detection.…”

Section: Diagnostics By Plasmonic Fluorescence Sensorsmentioning

confidence: 99%

Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases

Hasan,

Bok

2024

Biosensors

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The increasing demand for rapid, cost-effective, and reliable diagnostic tools in personalized and point-of-care medicine is driving scientists to enhance existing technology platforms and develop new methods for detecting and measuring clinically significant biomarkers. Humanity is confronted with growing risks from emerging and recurring infectious diseases, including the influenza virus, dengue virus (DENV), human immunodeficiency virus (HIV), Ebola virus, tuberculosis, cholera, and, most notably, SARS coronavirus-2 (SARS-CoV-2; COVID-19), among others. Timely diagnosis of infections and effective disease control have always been of paramount importance. Plasmonic-based biosensing holds the potential to address the threat posed by infectious diseases by enabling prompt disease monitoring. In recent years, numerous plasmonic platforms have risen to the challenge of offering on-site strategies to complement traditional diagnostic methods like polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA). Disease detection can be accomplished through the utilization of diverse plasmonic phenomena, such as propagating surface plasmon resonance (SPR), localized SPR (LSPR), surface-enhanced Raman scattering (SERS), surface-enhanced fluorescence (SEF), surface-enhanced infrared absorption spectroscopy, and plasmonic fluorescence sensors. This review focuses on diagnostic methods employing plasmonic fluorescence sensors, highlighting their pivotal role in swift disease detection with remarkable sensitivity. It underscores the necessity for continued research to expand the scope and capabilities of plasmonic fluorescence sensors in the field of diagnostics.

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Section: Diagnostics By Plasmonic Fluorescence Sensorsmentioning

confidence: 99%

Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases

Hasan,

Bok

2024

Biosensors

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“…The methods entail maneuverable operating procedures as well as affordable equipment, and many of them match the demand for specicity and sensitivity, which are applicable to many occasions such as RNA tests, antigen tests, and antibody tests. 82 Many researchers also suggest that such biosensors allow the reduction of the medical waste produced during the process to largely prevent environmental hazards from synthesis to recycling. 83 Luminescent semiconductor quantum dots (QDs) have become one of the most prevailing and promising NM-based technologies, especially in the eld of biology-related applications.…”

Section: Nanomaterial-based Technologymentioning

confidence: 99%

Current strategies for SARS-CoV-2 molecular detection

Xie

et al. 2022

Anal. Methods

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“…However, this approach is unsuitable for point-of-care testing because it requires specialized laboratories, sophisticated and expensive equipment, and trained personnel. Alternatively, several other methods, including electrochemical techniques [ 8 , 9 ], fluorescence [ 10 , 11 ], and impedance [ 12 , 13 ], have been demonstrated. Among these, biosensor field-effect transistors (BioFETs) have emerged as a promising approach due to their low cost, ultra-sensitivity, and label-free detection [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Sensing Characteristics of SARS-CoV-2 Spike Protein Using Aptamer-Functionalized Si-Based Electrolyte-Gated Field-Effect Transistor (EGT)

Shin,

Kim,

Choi

et al. 2024

Biosensors

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The sensing responses of SARS-CoV-2 spike protein using top-down-fabricated Si-based electrolyte-gated transistors (EGTs) have been investigated. An aptamer was employed as a receptor for the SARS-CoV-2 spike protein. The EGT demonstrated excellent intrinsic characteristics and higher sensitivity in the subthreshold regime compared to the linear regime. The limit of detection (LOD) was achieved as low as 0.94 pg/mL and 20 pg/mL for the current and voltage sensitivity, respectively. To analyze the sensing responses of EGT in detecting the aptamer–SARS-CoV-2 spike protein conjugate, a lumped-capacitive model with the presence of an effective dipole potential and an effective capacitance of the functionalized layer component was employed. The aptamer-functionalized EGT showed high sensitivity even in 10 mM phosphate-buffered saline (PBS) solution. These results suggest that Si-based EGTs are a highly promising method for detecting SARS-CoV-2 spike proteins.

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Prospects of NIR fluorescent nanosensors for green detection of SARS-CoV-2

Cited by 13 publications

References 132 publications

Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases

Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases

Current strategies for SARS-CoV-2 molecular detection

Sensing Characteristics of SARS-CoV-2 Spike Protein Using Aptamer-Functionalized Si-Based Electrolyte-Gated Field-Effect Transistor (EGT)

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