Prosta Fink Forte^®-Kapseln in der Behandlung der benignen Prostatahyperplasie. Eine multizentrische Anwendungsbeobachtung an 2245 Patienten

Abstract

Prosta Fink Forte^(r) in the Therapy of Benign Prostatic Hyperplasia. Multicentric Surveillance Study in 2,245 Patients Objective and Design:Therapeutic use and safety of a pumpkin seed extract were tested in a multicentric clinical trial. Patients and Methods:2,245 patients suffering from benign prostate hyperplasia (stage I to II according to Alken) received for 12 weeks 1–2 capsules Prosta Fink Forte per day. Urinary symptoms were recorded by the International Prostate Symptom Score according to the American Urological Association (I-PSS), the influence on quality of life has been recorded by a quality of life questionnaire (LQ Index). Results:The I-PSS decreased by 41.4%, life quality improved by 46.1% during therapy. More than 96% of the patients reported no undesired side effects under the treatment with Prosta Fink Forte. Conclusion:Prosta Fink Forte facilitates an efficient improvement of BPH symptoms, especially in early stages.

Pumpkin Seed Oil Extracted From Cucurbita maxima Improves Urinary Disorder in Human Overactive Bladder

“…have demonstrated that the pumpkin seed extract obtained from C. pepo improves abnormal urinary function in patients with BPH. [5] Oral administration of 500-1000 mg/day of this extract for 12 weeks caused International Prostate Symptom Scores to decrease by 41.4%. Moreover, more than 96% of the patients had no undesired side effect due to treatment with the oil.…”

“…Although the molecular mechanism of the seed oil for improvement of urinary tract disorders is not well understood from the current study, based on a previous report, it is speculated that sitosterols contained in the seed oil are responsible to alleviate these disorders. [5] As for the study design, it was an open-labeled trial because of excessive amount of oil volume required for encapsulation. To confirm the current results, we plan to perform a placebo-controlled, double-blind clinical trial when we identify the potential molecules, which would enable us to downsize the test or placebo sample volume good enough for encapsulation.…”

“…Ours was not a randomized, double-blind, and placebo-controlled study design. Recently, OABSS has been recognized as the standard system of evaluation in urinary function,[5] but the system involves evaluation by self-assessment. Furthermore, the sample size in our study was small.…”

“…In previous reports, the effect of the pumpkin seed oil from C. pepo has been investigated in clinical trials involving over 2000 men suffering from benign prostate hypertrophy (BPH). [5] The oil significantly improved their urinary dysfunction. In an animal study, Gossell-Williams et al .…”

Supplementation with extract of pumpkin seeds exerts estrogenic effects upon the uterine, serum lipids, mammary glands, and bone density in ovariectomized rats

“…Pumpkin seeds are edible and have been reported to contain lignan phytoestrogen secoisolariciresinol and lariciresinol (Phillips, Ruggio, & Ashraf‐Khorassani, ). They have also been shown to have a beneficial role in the management of benign prostatic hyperplasia, which is associated with the phytoestrogen content (Friederich, Theurer, & Schiebel‐Schlosser, ; Sicilia, Niemeyer, Honig, & Metzler, ). Pumpkin seeds contain approximately 265‐mg lignan phytoestrogens/100 g of seeds (Phillips et al, ) and 16‐mg tocopherols/100 g of seed.…”