Prostaglandin dynamics associated with development of the bovine conceptus

Thatcher, W.W.; Wolfenson, D.; Curl, J. S.; Rico, L.E.; Knickerbocker, J.J.; Bazer, Fuller W.; Drost, Maarten R.

doi:10.1016/0378-4320(84)90033-2

Cited by 58 publications

(24 citation statements)

References 29 publications

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“…However, although from the uterus appears to be the ultimate effector component of luteolysis in the cow (Nancarrow et ai, 1973;Shemesh & Hansel, 1975;Thatcher et al, 1984Thatcher et al, , 1985, recent evidence indicates that ovarian follicles also are involved (Chupin & Saumande, 1981;Villa-Godoy et al, 1985;. Increases in concentrations of oestradiol-17ß (originating from large follicles) in the uteroovarian vein adjacent to the CL-bearing ovary preceded the increase in PGF-2a before spontaneous luteolysis in the cow .…”

Section: Discussionmentioning

confidence: 99%

“…Factors originating from the conceptus (Northey & French, 1980;Heyman, Camous, Fevre, Meziou & Martal, 1984;Plante, Bousquet, Guay & Goff, 1984) appear to reduce endometrial secre¬ tion of PGF-2a (Knickerbocker, Thatcher, Bazer, Barron & Roberts, 1984;Thatcher et al, 1984) and contribute to CL maintenance during early pregnancy in the cow. However, although from the uterus appears to be the ultimate effector component of luteolysis in the cow (Nancarrow et ai, 1973;Shemesh & Hansel, 1975;Thatcher et al, 1984Thatcher et al, , 1985, recent evidence indicates that ovarian follicles also are involved (Chupin & Saumande, 1981;Villa-Godoy et al, 1985;.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian follicular development during early pregnancy in cattle

Guilbault¹,

Dufour²,

Thatcher³

et al. 1986

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Summary. On the day of oestrus (Day 0), 23 cows were assigned randomly to 4 groups in a 2 \ m=x\2 factorial experiment. Main percentage of non-atretic follicles (<4 pycnotic bodies) was lower (P<0\m=.\002) in pregnant than non-pregnant groups in the smallest class of antral follicles (0\ m=. \ 16\ p=n-\ 0\ m=. \ 28mm) but was higher (P<0\m=.\03) in larger classes (0\ m=. \ 68\ p=n-\ 3\ m=. \ 67mm) for pregnant groups. Percentages of atretic follicles were 3\m=.\7and 4\m=.\9(P>0\m=.\1)for follicles of 0\m=.\16\p=n-\0\m=.\67 mm, 91\m=.\1and 78\m=.\9for follicles of 0\m=.\68\p=n-\3\m=.\67mm (P<0\m=.\04) and 5\m=.\1and 16\m=.\1 (P<0\m=.\05) for follicles of 3\m=.\67\p=n-\78\m=.\56mm in pregnant and non-pregnant groups respectively. The percentage of atretic follicles classified as late atretic was higher in pregnant than in non-pregnant groups for follicles of 0\m=.\68\p=n-\1\m=.\57mm (P < 0\m=.\06) and 3\m=.\68\p=n-\8\m=.\56mm (P < 0\m=.\05). The results suggest that, as early as Day 17, the presence of a conceptus favours a more rapid turnover of follicles from class 1 (0\ m=. \ 16\ p=n-\ 0\ m=. \ 28mm) to classes 3 and 4 (0\ m=. \ 68\ p=n-\ 3\ m=. \ 67mm) but limits further growth by increasing atresia.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ovarian follicular development during early pregnancy in cattle

Guilbault¹,

Dufour²,

Thatcher³

et al. 1986

Reproduction

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“…These observations suggest that the uterine epithelium maintains a steep concentration gradient for PGF between luminal and endometrial extracellular fluid during pregnancy. This interpretation is, however, complicated by data from cows (Thatcher et al, 1984): PGF-2u was infused through the uterine lumen before, during and after PGE-2 was added to the infusate. During the combined PGE-2 and PGF-2a infusion, the output rates (nglmin) of PGF-2u and PGFM were elevated in the utero-ovarian vein concurrently with increased uterine blood flow.…”

Section: Permeability and Transport Properties Of Uterine Epitheliummentioning

confidence: 99%

“…However, PGF-2u infused into the uterine lumina of pregnant and non-pregnant cows was associated with marked elevations of PGFM in jugular plasma by 20 min after initiation of infusion (Thatcher et al, 1984). Clearly then, prostaglandins are able to cross the blood-uterine lumen barrier in cows.…”

Section: Permeability and Transport Properties Of Uterine Epitheliummentioning

confidence: 99%

“…As a result, transport of prostaglandins across uterine plasma membranes is likely to require a carrier mechanism. In-vitro studies of prostaglandin uptake by uterine epithelial cell plaques from rabbits (Jones & Harper, 1983) and by endometrial cells from cows (Thatcher et a[., 1984) suggest that these tissues are able to concentrate prostaglandins intracellularly (i.e. ratios of tissue to medium concentrations, corrected for extracellular fluid volumes, greater than 1.0).…”

Section: Permeability and Transport Properties Of Uterine Epitheliummentioning

confidence: 99%

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The blood-uterine lumen barrier and exchange between extracellular fluids

McRae¹

1988

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Summary. The concept of a blood-tissue barrier defines the rates at which matter exchanges among the vascular and extravascular fluids of the tissue. The remarkably slow rates at which substances such as mannitol ( M , 182) enter uterine fluid from plasma demonstrate the existence of a blood-uterine lumen barrier. Available evidence indicates that the uterine microvascular endothelium and the uterine epithelium behave as lipoid layers interrupted by water-filled channels. Furthermore, both cell layers appear to select actively certain substances over others for exchange with opposing extracellular fluids. In contrast to these similarities, the uterine epithelium and endothelium differ considerably with regard to restrictiveness. For most substances the primary rate-limiting boundary between blood and the uterine lumen is the epithelium. The extracellular fluid compartments of the lumen and endometrium are also influenced by the internalization and release of materials into and out of intracellular compartments including those of the stromal and migratory cells of the endometrium, the epithelium and the developing conceptus. Considerable evidence suggests that the luminal milieu of the developing embryo is created and maintained by the transport and permeability properties o r the blood-uterine lumen barrier in conjunction with the cellular activities of the endometrium and embryo. This milieu probably fulfils the informational and nutritional needs of the developing embryo.

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Effect of heat exposure on prostaglandin production and expression of COX-2, PGES, PGFS, ITGAV and LGALS15 mRNAs in endometrial epithelial cells of buffalo (Bubalus bubalis)

Mondal,

Mor,

Reddy

et al. 2024

Mol Biol Rep

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The present study aimed to investigate the in uence of heat stress on prostaglandin production and the expression of key genes, including COX-2, PGES, PGFS, ITGAV, and LGALS15, in buffalo endometrial epithelial cells. Buffalo genitalia, containing ovaries with corpus luteum (CL), were collected immediately post-slaughter and transported to the laboratory. The stages of estrous cycle were determined based on macroscopic observations of the ovaries, and uteri from the mid luteal phase (days 6-10 of the estrous cycle) were utilized. Uterine lumens were washed and treated with trypsin to isolate epithelial cells, which were then cultured at control temperature (38.5°C for 24 hr) or exposed to elevated temperatures (38.5°C for 6 hr, 40.5°C for 18 hr; HS). The supernatant and endometrial epithelial cells were collected at various time points (0, 3, 6, 12, and 24 hr) from both control and treatment group. Despite the elevated temperature (40.5°C) not affecting the in vitro production of PGF 2α and PGE 2 in epithelial cells, there was a signi cant (P < 0.05) increase in COX-2, PGES, and PGFS transcripts in response to heat stress.Interestingly, the expression of ITGAV and LGALS15 mRNAs in endometrial epithelial cells remained unaltered under elevated temperature conditions. In conclusion, this study suggests that while elevated temperature did not directly modulate prostaglandin production, it promoted the expression of COX-2, PGES, and PGFS mRNA in buffalo endometrial epithelial cells. These ndings contribute to our understanding of the molecular responses of buffalo reproductive cells to heat stress, potentially informing strategies for mitigating the impact of environmental factors on reproductive outcomes in this species.

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Prostaglandin dynamics associated with development of the bovine conceptus

Cited by 58 publications

References 29 publications

Ovarian follicular development during early pregnancy in cattle

Ovarian follicular development during early pregnancy in cattle

The blood-uterine lumen barrier and exchange between extracellular fluids

Effect of heat exposure on prostaglandin production and expression of COX-2, PGES, PGFS, ITGAV and LGALS15 mRNAs in endometrial epithelial cells of buffalo (Bubalus bubalis)

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