Prostaglandin E1, prostaglandin E2, and endotoxin failure to produce fever in the Japanese freshwater snail Semisulcospira libertina.

Abstract

The thermopreferendum (preferred temperature) of the Japanese freshwater snail (Semisulcospira libertina) was determined in an aquatic temperature gradient after injection of prostaglandin E1, prostaglandin E2, and LPS. Injected doses of each pyrogen ranged from a toxic dose to less than 1/20th of the toxic dose. Toxic effect of the highest doses of pyrogen disappeared within 120 min. No fever occurred during the 150 min observation following the pyrogen injection. The present results support the hypothesis that fever was selected as a way of defending against infection only after the period of the emergence of the molluscus, i.e., the early Cambrian period.

Thermal preferences of wintering snails Planorbarius corneus (L.) exposed to lipopolysaccharide and zymosan

“…Ma'aqbeh (2010) underlined that phagocytosis activity of snail hemocytes was highest at 25°C, higher than at 15°C but also at 35 and 40°C. Our observation of behavioral fever symptoms in P. corneus individuals is in contradiction with the results of Cabanac and Rossetti (1987), Rossetti and Nagasaka (1988) and Cabanac (1989). Authors who, testing L. auricularia or Semisulcospira libertina, in a thermal gradient, found unequivocally no capacity for fever in those snails, and generalized this thesis to include all mollusks.…”