Prostaglandin E2 for induction of labor in patients with premature rupture of membranes at term

Ray, Deborah A.; Garite, Thomas J.

doi:10.1016/0002-9378(92)91344-a

Cited by 57 publications

(24 citation statements)

References 14 publications

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“…All had uneventful neonatal hospital stays. 2.8% (term babies), 4.5% Ray and Garite, 1-3.4% cases in our studies, 2.79% cases in Chua et al [8][9][10][11] In a study conducted by Ezechi OC for induction of labour in PROM patients with PG E1 (misoprostol) LSCS rate was 18.6%, Hyper stimulation rate was 3% Rate of fetal distress was 10.2% and birth asphyxia rate was 3% which is more in comparison to our study. 12 In a study conducted by Bangal VB et al vaginal delivery rate was 88%, LSCS rate was 12%, fetal distress was seen in 8% of the patients and hyper bilirubinemia in 20% of the patients, the rate of normal delivery is less compared to our study and fetal distress is more compared to our study.…”

Section: 8-11supporting

confidence: 44%

Intracervical PGE2 gel for induction of labour in patients with prelabour rupture of membranes with unfavorable cervix after 34 weeks period of gestation

Jayaprakash¹,

Muralidhar²,

Venkatesh³

2016

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONPre labour rupture of membranes (PROM) occurs in 5-10% of all pregnancies. Approximately 60% of cases of PROM occur in term patients. The etiology and pathophysiology of PROM is obscure and hence opinion regarding management of this disorder varies widely.1 pre labour rupture of membranes is associated with maternal and neonatal infection, cord prolapse and fetal compromise which may result in operative delivery or low APGAR score at five minute. 2 Pre labour rupture of membranes is also associated with chorioamnionitis in 6-10% of women at term and up to 40% in women with membranes ruptured for more than 24 hours. Therefore Department of Obstetrics and Gynaecology, Vydehi institute of medical sciences and research centre, EPIP area, Nallurahalli, Bangalore, Karnataka, India ABSTRACTBackground: Premature rupture of membranes (PROM) occurs in 5-10% of all pregnancies. Approximately 60% of cases of PROM occur in term patients. Intra-vaginal or intra-cervical PGE2 has been found to be efficacious in inducing labour at term with the majority of patients delivered with or without the aid of oxytocin, most within 24 hours. But the use of PGE2 gel in patients with PROM and unfavorable cervix to induce labour is not widely accepted possibly for fear of introduction of infection and for draining away the gel with liquor. The objective of this study was to evaluate the efficacy of prostaglandin E2 gel (Dinoprostone 0.5mg) for induction of labour in patients with PROM at term and 34-37 weeks of gestation with an unfavorable cervix. Methods: Study was performed at Vydehi Institute of Medical Sciences and Research Centre from February 2013 to June 2015. Eligible patients included those at term and 34 to 37 weeks of gestation with spontaneous rupture of membranes who presented before onset of labour. All patients had singleton pregnancy with vertex presentation. All patients received a single intra-cervical application of 0.5 mg PGE2 gel. If labour was not established at 6 hours, repeat cervical assessment was done and those with unfavorable cervix received 2nd dose of intra-cervical application of PGE2 gel. After an additional 6 hours, patients with low Bishop's scores were tried with oxytocin titration infusion. Results: Of the 80 patients 68 patients (85%) began labour after single application, 12 patients (15%) required 2

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Section: 8-11supporting

confidence: 44%

Intracervical PGE2 gel for induction of labour in patients with prelabour rupture of membranes with unfavorable cervix after 34 weeks period of gestation

Jayaprakash¹,

Muralidhar²,

Venkatesh³

2016

Int J Reprod Contracept Obstet Gynecol

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“…However, they have not mentioned any specific contraindication of using PGE 2 in PPROM patients. In fact, the American Congress of Obstetricians and Gynecologists and Ray and Garite [10] refer to the safety and effectiveness of PGE 2 in the context of PROM, and a 2004 study of 262 patients with both term and preterm PROM found that there were no apparent maternal or fetal complications in women who were administered PGE 2 [11]. In our study, PPROM showed a significantly higher success rate of induction than did the other groups, with no differences in terms of intrapartum complications such as tachysystole or non-reassuring fetal heart rate.…”

Section: Discussionmentioning

confidence: 99%

Predicting factors for success of vaginal delivery in preterm induction with prostaglandin E₂

et al. 2017

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ObjectiveTo evaluate the efficacy and safety of prostaglandin (PG) E2 for preterm labor induction and to investigate the predictive factors for the success of vaginal delivery.MethodsA retrospective cohort study was performed in women (n=155) at 24+0 to 36+6 weeks of gestation who underwent induction of labor using a PGE2 vaginal pessary (10 mg, Propess) from January 2009 to December 2015. Success rates of vaginal delivery according to gestational age at induction and incidence of intrapartum complications such as tachysystole and nonreassuring fetal heart rate were investigated. Multivariable logistic regression analysis was performed to evaluate the predictive factors for success of labor induction.ResultsThe vaginal delivery rate was 57% (n=89) and the rate of cesarean delivery after induction was 43% (n=66). According to gestational age, labor induction was successful in 16.7%, 50.0%, and 62.8% of patients at 24 to 31, 32 to 33, and 34 to 36 weeks, showing a stepwise increase (P=0.006). There were 18 cases (11%) of fetal distress, 9 cases (5.8%) of tachysystole, and 6 cases (3.8%) of massive postpartum bleeding (>1,000 mL). After adjusting for confounding factors, multiparity (odds ratio [OR], 8.47; 95% confidence interval [CI], 3.10 to 23.14), younger maternal age (OR, 0.84; 95% CI, 0.75 to 0.94), advanced gestational age at induction (OR, 1.06; 95% CI, 1.02 to 1.09), rupture of membranes (OR, 11.83; 95% CI, 3.55 to 39.40), and the Bishop score change after removal of PGE2 (OR, 2.19; 95% CI, 1.0 to 4.8) were significant predictors of successful preterm vaginal delivery.ConclusionAn understanding of the principal predictive factors of successful preterm labor induction, as well as the safety of PGE2, will provide useful information when clinicians consult with preterm pregnant women requiring premature delivery.

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“…Only 47 (6%) of the nulliparous women in the study population had a Bishop score of 1 or 2. In women with a very low Bishop score, the administration of prostaglandins may be a useful alternative to ripen the cervix 16 . However, since these patients are rare, their existence does not indicate that a routine digital examination should be performed at admission.…”

Section: Discussionmentioning

confidence: 99%

A randomised trial of two expectant managements of prelabour rupture of the membranes at 34 to 42 weeks

Ladfors

Mattsson

Eriksson

et al. 1996

BJOG

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Objective To compare obstetric and perinatal outcome between two different expectant managements in women with prelabour rupture of the membranes (PROM). Design A randomised study. Participants One thousand three hundred and eighty‐five women with rupture of the membranes at 34 to 42 weeks without contractions. Interventions Women without contractions 2 h after admission were randomised to early induction the following morning after PROM (early induction group) or induction two days later (late induction group). Women with contractions starting within 2 h after admission were included in the calculations as a short latency group. Digital examinations of the cervix were avoided until onset of active labour. Labour was induced with oxytocin in both groups if no spontaneous contractions occurred or if chorioamnionitis or fetal distress was detected. Main outcome measures The frequency of spontaneous deliveries, operative deliveries, maternal and neonatal infections. Results In nulliparous women, a higher rate of spontaneous deliveries was found in the late induction group (89%) compared with the early induction group (81%) (P < 0.05). The ventouse extraction rate was 7% and 14% respectively (P < 0.05). A low (2–4%) caesarean section rate was recorded and did not differ between the groups. Endometritis was detected in six women after delivery. Sixty‐one children were treated with antibiotics, and no difference could be detected between the groups. Conclusions A higher rate of spontaneous deliveries was found among nulliparous women with prolonged latency as compared with brief latency prior to induction. A protocol of no digital examination before labour was associated with infrequent maternal and fetal morbidity, regardless of latency.

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Prostaglandin E2 for induction of labor in patients with premature rupture of membranes at term

Cited by 57 publications

References 14 publications

Intracervical PGE2 gel for induction of labour in patients with prelabour rupture of membranes with unfavorable cervix after 34 weeks period of gestation

Intracervical PGE2 gel for induction of labour in patients with prelabour rupture of membranes with unfavorable cervix after 34 weeks period of gestation

Predicting factors for success of vaginal delivery in preterm induction with prostaglandin E₂

A randomised trial of two expectant managements of prelabour rupture of the membranes at 34 to 42 weeks

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Prostaglandin E2 for induction of labor in patients with premature rupture of membranes at term

Cited by 57 publications

References 14 publications

Intracervical PGE2 gel for induction of labour in patients with prelabour rupture of membranes with unfavorable cervix after 34 weeks period of gestation

Intracervical PGE2 gel for induction of labour in patients with prelabour rupture of membranes with unfavorable cervix after 34 weeks period of gestation

Predicting factors for success of vaginal delivery in preterm induction with prostaglandin E2

A randomised trial of two expectant managements of prelabour rupture of the membranes at 34 to 42 weeks

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Predicting factors for success of vaginal delivery in preterm induction with prostaglandin E₂