Prostaglandin Effects on Rat Pregnancy. II. Interruption of Pregnancy

Fuchs, Anna‐Riitta; Mok, Élise

doi:10.1016/s0015-0282(16)39612-1

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1974

1984

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Cited by 17 publications

(1 citation statement)

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“…In rats, hypophysectomy does not delay parturi¬ tion (Rodway & Kuhn, 1975). It has been suggested that prostaglandin (PG) F-2a, which is able to induce luteolysis in late pregnancy (Fuchs & Mock, 1973 ;Dukes, Chester & Atkinson, 1974;Fuchs, Mock & Sundaram 1974;Strauss et al, 1975), might be the initiator of parturition in rats.…”

Section: Introductionmentioning

confidence: 99%

A local signal from the gravid horn to the ovary for the onset of parturition in rats

Cavaillé¹,

Maltier²

1978

Reproduction

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Section: Introductionmentioning

confidence: 99%

A local signal from the gravid horn to the ovary for the onset of parturition in rats

Cavaillé¹,

Maltier²

1978

Reproduction

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Potential Value of Plants As Sources of New Antifertility Agents I *

Farnsworth¹

1975

Journal of Pharmaceutical Sciences

208

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Teratology study with the synthetic prostaglandin ONO‐802 given intravaginally to rabbits

Petrere¹,

Humphrey²,

Sakowski³

et al. 1984

Teratog Carcinog Mutagen

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ONO-802, a synthetic E1 prostaglandin, was administered intravaginally via pessaries to Dutch belted rabbits at doses of 250, 62.5, and 12.5 micrograms/kg on days 6 through 18 of gestation. Rabbits in a vehicle control group were treated with pessaries that did not contain ONO-802 during the same period. Another group of animals remained untreated throughout gestation. Necropsies were performed on rabbits found dead and on those killed on gestation day 30. Body weight, food and water consumption, and clinical signs were monitored during the experiment. Major organs were weighed when the dams were necropsied on gestation day 30, and litter and fetal data were collected. Abortion and maternal deaths occurred in drug-treated groups. Body weight gains and food and water consumption were adversely affected by treatment particularly at the 250 and 12.5 micrograms/kg dose levels. Wastage (postimplantation loss) was significantly increased among treated groups (all dose levels), while other litter and fetal parameters were unaffected. ONO-802 was not teratogenic at maternal and embryotoxic dose levels.

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Prostaglandin Effects on Rat Pregnancy. II. Interruption of Pregnancy

Cited by 17 publications

References 23 publications

A local signal from the gravid horn to the ovary for the onset of parturition in rats

A local signal from the gravid horn to the ovary for the onset of parturition in rats

Potential Value of Plants As Sources of New Antifertility Agents I *

Teratology study with the synthetic prostaglandin ONO‐802 given intravaginally to rabbits

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