Prostaglandin F2α levels in sera during human pregnancy

Gutierrez‐Cernosek, Rose Mary; Zuckerman, James E.; Levine, Lawrence

doi:10.1016/s0090-6980(72)80010-8

Cited by 31 publications

(6 citation statements)

References 12 publications

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“…The concentration of PGF-2a increases in the blood serum during labour in women and declines sharply immediately following parturition (Brummer, 1972 ;Guttierrez-Cernosek et al, 1972). The findings of the present study clearly show that PGF-2a levels also increase in the peripheral blood of mares during foaling.…”

supporting

confidence: 67%

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Release of Prostaglandin F-2 During Foaling in Mares

Sharma¹

1975

Reproduction

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supporting

confidence: 67%

“…Increased concentrations of prostaglandin F-2a before and during parturition in women (Karim, 1968;Guttierrez-Cernosek et al, 1972), and sheep (Liggins & Grieves, 1971; Thorburn et al, 1972) have been reported. This paper de¬ scribes the circulating levels of PGF-2a in the peripheral blood of mares at the time of foaling.…”

mentioning

confidence: 96%

Release of Prostaglandin F-2 During Foaling in Mares

Sharma¹

1975

Reproduction

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“…Peripheral plasma or serum PGF levels in the human during pregnancy have been reported to be unchanged or to increase slightly (145,146), to increase to a peak during the second trimester (173), or to reach the lowest values during this period (176,177). Peripheral plasma or serum PGF levels in the human during pregnancy have been reported to be unchanged or to increase slightly (145,146), to increase to a peak during the second trimester (173), or to reach the lowest values during this period (176,177).…”

Section: Gas Chromatography-mass Spectrometrymentioning

confidence: 99%

Prostaglandins

Samuelsson¹,

Granström²,

Green³

et al. 1975

Annu. Rev. Biochem.

567

170

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“…The anti-PGE2-M cross-reacted with 13,14-dihydro-PGE2, 15-keto-PGEz, 13,14-dihydro-15-keto-PGF2~, 13,14-dihydro-15-keto-PGA2, PGE2, and PGA2 0.2, 7.0, 5.0, 0.4, 0.1, and 0.08%, respectively (26). Plasma for PGE2-M assay was extracted with 3 vol of methylalethanol and concentrated as described previously for human samples (27). Several extracts of rabbit plasma were assayed with anti-13,14-dihydro-15-keto-PGF2~.…”

Section: Methodsmentioning

confidence: 99%

Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma.

Voelkel¹,

Levine²,

Alper³

et al. 1978

The Journal of Experimental Medicine

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Results of a series of studies on the cause of the hypercalcemia that occurs in mice bearing the HSDM~ fibrosarcoma (1-6) and in rabbits carrying the VX2 carcinoma (7-9) have led us to conclude that these two tumors synthesize and secrete large amounts of prostaglandin E2 (PGE2) into plasma. ~ PGE~ is a potent bone resorption-stimulating agent in vitro (2, 10), and this prostaglandin and its metabolites are found in elevated concentrations in the plasma of tumor-bearing animals (2,3,(6)(7)(8)11). Because of the rapid clearance and metabolism of PGE2, measurements in plasma of the metabolite, 13,14-dihydro-15-keto-PGE2(PGE2-M), give a more accurate estimate of PGE~ secretion than do measurements of the primary prostaglandin itself (6,8,11,12). Studies on the time-course of the development of elevated plasma calcium concentrations and hyperprostaglandinemia, as well as investigations using two inhibiters of prostaglandin synthesis, indomethacin (1-3, 7) and hydrocortisone (6,8,13), support the hypothesis that the hypercalcemic syndrome in these tumor-bearing animals is due to the secretion of PGE2 by the tumor. A similar pathophysiologic mechanism may explain in part the hypercalcemia that occurs in certain patients with cancer (14-16).The present investigation was initiated because of the observation that the plasma from rabbits bearing the VX~ carcinoma became faintly blue about I wk after tumor implantation, and this color increased markedly and became intense by 3-4 wk. The time-course of the appearance and increase in the blue color in plasma was similar to that which we had previously noted for PGEz-M. We therefore undertook to identify the blue material in plasma and to examine the relationship of its increase to prostaglandin metabolism. Our findings indicate that the material is ceruloplasmin, that its rise correlates closely with plasma concentrations of PGE2-M, and that beth PGE2-M and ceruloplasmin increase in the plasma of tumor-bearing rabbits before the development of hypercalcemia.

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Prostaglandin F2α levels in sera during human pregnancy

Cited by 31 publications

References 12 publications

Release of Prostaglandin F-2 During Foaling in Mares

Release of Prostaglandin F-2 During Foaling in Mares

Prostaglandins

Acute phase reactants ceruloplasmin and haptoglobin and their relationship to plasma prostaglandins in rabbits bearing the VS2 carcinoma.

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