Prostaglandin prodrugs I: Stabilization of dinoprostone (prostaglandin E2) in solid state through formation of crystalline C1-phenyl esters

Chronic nutritional injury was induced in rats by a high-fat, lipotrope-deficient diet. The hepatoprotective effect of 16,16-dimethyl prostaglandin E2 on the deposition of collagen and fat was assessed by histological evaluation and measurement of hydroxyproline. Dose-response studies established that optimal protection was achieved by the twice daily administration of 16,16-dimethyl prostaglandin E2 at 100 micrograms per kg (subcutaneous) or 250 micrograms per kg (oral). 16,16-Dimethyl prostaglandin E2 and a crystalline analog [(p-acetamidobenzamido)phenyl ester of 16,16-dimethyl prostaglandin E2 significantly delayed both the deposition of collagen and the increase in hepatic hydroxyproline content. There was an excellent correlation between the histological assessment of collagen and the biochemical measurement of hydroxyproline. These data provide a rationale for the evaluation of prostaglandins in the treatment of human liver disease.

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16,16-dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver†

Ruwart

Rush

Snyder

et al. 1988

Hepatology

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Prostaglandin Prodrugs II: New Method for Synthesizing Prostaglandin C1-Aliphatic Esters

Morozowich

Oesterling

Miller

et al. 1979

Journal of Pharmaceutical Sciences

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Prostaglandin Prodrugs III: Synthesis and Biological Properties of C9- and C15CIS-Monoesters of Dinoprost (Prostaglandin F2α)

Morozowich

Oesterling

Miller

et al. 1979

Journal of Pharmaceutical Sciences

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Prostaglandin prodrugs I: Stabilization of dinoprostone (prostaglandin E2) in solid state through formation of crystalline C1-phenyl esters

Cited by 14 publications

References 8 publications

16,16-dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver†

16,16-dimethyl prostaglandin E2 delays collagen formation in nutritional injury in rat liver†

Prostaglandin Prodrugs II: New Method for Synthesizing Prostaglandin C1-Aliphatic Esters

Prostaglandin Prodrugs III: Synthesis and Biological Properties of C9- and C15CIS-Monoesters of Dinoprost (Prostaglandin F2α)

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