Prostaglandins in Normal and Pathological Skin

Søndergaard, Jørgen

doi:10.1111/j.1600-0560.1974.tb00639.x

Cited by 7 publications

(1 citation statement)

References 99 publications

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“…Hop efully they might now be per suaded to study bicarbon ate production in the stomach in CF. PGE z ha s now been shown to be present in epitheli al tissue s throughout the body, for example, in the male and fem ale reproductive tract s , the lungs (21), the kidn ey tubules (22), the skin (where its concentration is high) (23), and in the sweat (24,25). It is therefor e present norm ally in all areas whe re CF secretions are affec ted.…”

mentioning

confidence: 99%

Hypothesis Revisited

Anderson

1984

J. pediatr. gastroenterol. nutr.

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SummaryAn earlier hypothesis based on the results of pancreatic studies in cystic fibrosis (CF) patients without steatorrhoea suggesting that the basic defect was related to an abnormality in control of electrolyte movement, particularly the bicarbonate ion, and water in exocrine secretory tissue is reviewed in light of recent advances in knowledge of secretory mechanisms. Evidence for defective bicarbonate–chloride exchange in a variety of CF exocrine tissues other than the pancreas is cited. Recent recognition of the close relationship between bicarbonate and mucus secretion and their stimulation by prostaglandin E2 is discussed. Consideration is given to the possibility of altered metabolism of PGE2 because of abnormal handling of essential fatty acids in CF, and an attempt is made to relate such a defect to the recent confirmation of oligosaccharide side chain differences such as an increased fucose–sialic acid ratio in CF gastrointestinal mucus and other glycoproteins. It is suggested that membrane permeability to chloride, bicarbonate–chloride exchange, and movement of water through extra‐and intracellular exocrine tissues depends on modifications of the carbohydrate structure of glycoproteins during secretion and that these changes are stimulated by co‐ordination of cell messengers PGE2, calcium, and cyclic AMP. Disturbed PGE2 metabolism in CF could inhibit these changes rendering resulting secretions dry, concentrated, and readily able to block ducts or tubes.

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mentioning

confidence: 99%

Hypothesis Revisited

Anderson

1984

J. pediatr. gastroenterol. nutr.

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Prostaglandinähnliche Substanzen Potentieller Faktor für die Entwicklung entzündlicher Akne-Läsionen

Hellgren¹,

Vincent²

1980

Fette, Seifen, Anstrichm.

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Die Isolierung und Bestimmung prostaglandinahnlicher Substanzen aus Propionibacterium acnes wird behandelt. Prostaglandinahnliche Substanzen ahneln Prostaglandinen der E-Serie, von denen man annimmt, daB sie Entziindungsmittler sind. AuDerdem hemmen die prostaglandinahnlichen Substanzen als potente Reizmittel verschiedener glatter Muskeln sowie als Chemoattraktoren die Blutplattchenaggrega tion und verursachen eine Erhohung der c-AMP. In vivo induzieren sie signifikante Veranderungen der Hamsterbadcentashen-Mikrozirkulation. Ihre Reaktionen in verschiedenen biologishen Systemen sind ahnl i h , jedoch nicht dieselben wie die des PGE,. Die GC-MS-Analyse bestatigt, da5 prostaglandinahnliche Substanzen nicht mit PGE, identisch sind. Es scheint somit, da5 prostaglandinahnliche Substanzen einen bedeutenden bakteriellen Metabolit bei Akneentziindungen darstellen.

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