Prostaglandins

Wilson, David

doi:10.1001/archinte.1974.00320130114009

Cited by 46 publications

(1 citation statement)

References 40 publications

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“…Recent investigations, in which contact with ricinoleic acid induced depression of intestinal contractile activity rather than stimulation, have challenged this view (Gaginella, Stewart & In the light of this inflammatory activity many * Correspondence. parallels can be drawn between the intestinal effects of ricinoleic acid and those of prostaglandins (Wilson, 1974), which are capable of inducing diarrhoea by themselves. Furthermore, inflammatory reactions have now for some time been associated with stimulation of prostaglandin biosynthesis (Piper & Vane, 1971).…”

mentioning

confidence: 99%

Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis

Awouters

Niemegeers

et al. 1978

Journal of Pharmacy and Pharmacology

283

201

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Forty-four non-steroidal anti-inflammatory compounds were tested for possible effects on castor oil-induced diarrhoea in rats. A small but significant delay of intestinal evacuations was found with all compounds. Quantitatively, the oral doses required to delay diarrhoea beyond the first hour after castor oil challenge reflected the acute anti-inflammatory potency of the tested compounds. Qualitatively, the evolution of the effective doses with increasing delay was linear for potent inhibitors of prostaglandin biosynthesis. The evolution for less potent compounds was markedly different and suggested the earlier occurrence of non-specific drug effects. Suprofen, the most potent of the series of compounds, produced the 1 h delay at an oral dose of 1.11 mg kg-1; the ED50 increased linearly to 115 mg kg-1 for a 4 h delay. Compared with other compounds the activity pattern of suprofen was consistent with that of a very potent, short-acting inhibitor of prostaglandin biosynthesis, which maintains its specific action over a wide dose range. It is concluded that delay of castor oil-induced diarrhoea in rats allows a detailed characterization of aspirin-like compounds, and that inhibition of prostaglandin biosynthesis is insufficient to suppress the intestinal effects of the oil.

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mentioning

confidence: 99%

Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis

Awouters

Niemegeers

et al. 1978

Journal of Pharmacy and Pharmacology

283

201

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Colostomy irrigation with prostaglandin E2 and bisacodyl. A double-blind cross-over study

Kjærgaard

Christensen

Stadil

et al. 1984

Journal of British Surgery

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The emptying of the colon and the side-effects after intraluminal application of prostaglandin E2 and of bisacodyl in 14 patients was studied by employing colostomy irrigation. The design was double-blind with cross-over, the irrigation was one litre of tap water to which was added in randomized sequence placebo, prostaglandin *2 (350, 700 and 1400 micrograms) or bisacodyl (1.25, 2.5 and 5 mg). Neither prostaglandin E2 nor bisacodyl had any significant effect.

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The effect of indomethacin on acute radiation induced gastrointestinal injury: A morphologic study

Rose

Halter

1992

Journal of Surgical Oncology

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Radiation-induced intestinal injury is a dose limiting factor in the treatment of pelvic, abdominal, and retroperitoneal malignancies with radiation therapy. In experimental models, radiation has been associated with increased intestinal prostaglandin activity and in clinical trials prostaglandin inhibitors have been demonstrated to improve the symptoms of acute radiation enteritis. This study was conducted to determine if the prostaglandin inhibitor indomethacin could prevent the morphologic changes of acute radiation induced intestinal injury. Twenty-four male rats received either parenteral indomethacin at doses of 0.5, 1.0, and 3.0 mg/kg per dose every 12 hours or saline from 24 hours pre-radiation exposure until sacrifice 48 hours later. Twenty-four control animals received identical drug dosages and anesthesia but no radiation. Radiation produced a decreased villus/crypt ratio and increased acute inflammation and degeneration. Indomethacin treated animals demonstrated significantly less polymorphonuclear leukocyte infiltration and decreased degeneration. Villus/crypt ratio was not affected by indomethacin.

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Prostaglandins

Cited by 46 publications

References 40 publications

Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis

Delay of castor oil diarrhoea in rats: a new way to evaluate inhibitors of prostaglandin biosynthesis

Colostomy irrigation with prostaglandin E2 and bisacodyl. A double-blind cross-over study

The effect of indomethacin on acute radiation induced gastrointestinal injury: A morphologic study

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