Prostanglandin D2 modulates human neutrophil intracellular calcium flux and inhibits superoxide release via its ring carbonyl

Simpkins, Cuthbert O.; Mazorow, Denise L.; Alailima, S.; Tate, E.; Sweatt, William C.; Johnson, Mark E.; Shariff, Khareem; Millar, David B.

doi:10.1016/0024-3205(90)90067-2

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…These results suggest that DP-mediated signals may not, in nature, lead to chemotactic or chemokinetic behavior in leukocytes. Although PGD 2 has been reported to modulate various activities of neutrophils, we could not detect any substantial expression of CRTH2 or DP in blood neutrophils (25). However, further studies are required to finally establish the actual involvement of these receptors in the PGD 2 -induced modulation of neutrophils.…”

Section: Discussioncontrasting

confidence: 70%

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

Hirai

Tanaka²,

Yoshie

et al. 2001

The Journal of Experimental Medicine

1,008

916

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Prostaglandin (PG)D2, which has long been implicated in allergic diseases, is currently considered to elicit its biological actions through the DP receptor (DP). Involvement of DP in the formation of allergic asthma was recently demonstrated with DP-deficient mice. However, proinflammatory functions of PGD2 cannot be explained by DP alone. We show here that a seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD2. In response to PGD2, CRTH2 induces intracellular Ca2+ mobilization and chemotaxis in Th2 cells in a Gαi-dependent manner. In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2.

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Section: Discussioncontrasting

confidence: 70%

Prostaglandin D2 Selectively Induces Chemotaxis in T Helper Type 2 Cells, Eosinophils, and Basophils via Seven-Transmembrane Receptor Crth2

Hirai

Tanaka²,

Yoshie

et al. 2001

The Journal of Experimental Medicine

1,008

916

View full text Add to dashboard Cite

show abstract

“…DP 1 receptors are known to occur on mucus-secreting goblet cells of the human nasal mucosa and colon, nasal serous glands and vascular endothelium, antigen-challenged murine bronchiolar and alveolar epithelia, T H 2 cells, DC, and eosinophils [85,91]. Contradictory reports regarding the existence and influence of DP 1 receptors on neutrophils preclude this characterization [92,93]. An array of different physiological processes has been attributed to DP 1 -mediated signaling, including sleep promotion [94], eosinophil survival [90], allergic asthma [13], mucus secretion [85], cytokine and chemotactic inhibition [91,95,96], control of intraocular pressure [97,98], and increased vascular permeability [85].…”

Section: Dp 1 Receptorsmentioning

confidence: 93%

“…These receptors are expressed on cells of hemopoietic origin, including eosinophils, basophils, monocytes, T H 2 and type 2 T cytotoxic cells and in nonhemopoietic tissues, such as cardiac and within the digestive and central nervous systems [88]. Contradictory reports regarding the existence and influence of DP 2 receptors on neutrophils precludes any relevant characterization in this regard [92,93]. DP 2 receptors are selectively expressed on T H 2 cells in humans, though they are expressed on both T H 1 and T H 2 cells in mice [100].…”

Section: Dp 2 Receptorsmentioning

confidence: 98%