Prostate cancer brachytherapy: is real-time ultrasound-based dosimetry predictive of subsequent CT-based dose distribution calculation? a study of 450 patients by the Institut Curie/Hospital Cochin (Paris) Group

Long-term results of permanent implant prostate cancer brachytherapy: A single-institution study of 675 patients treated between 1999 and 2003

“…The dosimetric values were then recalculated and compared to the (ultrasound-based) intraoperative dosimetric values [16].…”

Poor Predictive Value of Intraoperative Real-Time Dosimetry for Prostate Seed Brachytherapy

“…It is therefore desirable to identify patients with an insufficient implant while he is still in the operating room and in the treatment position, so that one can complete an implant in a timely and technically simple fashion. A correlation has already been shown to exist between the intraoperative plan and the CT scan performed 1-2 months after the procedure (11,12). We carried out this study to evaluate the value of dosimetry derived from TRUS performed before and after the implantation in the operating room to predict for the quality of the implant measured 4 weeks after the implant.…”

“…Several centers are using IO image acquisition and planning, which allow for plan modification in real time with IO needle placement through an interactive or dynamic planning system (5)(6)(7)(8)(9)(10). Although some studies have shown a correlation between IO preimplant dosimetry and postimplant CT dosimetry, to our knowledge, there has yet to be a study that has shown a correlation between the IO postimplant dosimetry and the Day 28 CT scan (11,12). If such a correlation does exist, this information could help identify patients who need a modification of the implant in the operating room.…”

Permanent prostate brachytherapy: a century of technical evolution

“…45 This dosimetric assessment gives valuable feedback to the operator team and provides a quality assurance. Several groups have found that intraoperative dosimetry correlates well with subsequent postoperative analysis 34,47,49 suggesting that satisfactory intraoperative dosimetry is a valid end point that may negate the need for routine postimplant analysis in the future.…”

“…Mathematico-clinical models and improved understanding will help achieve the goals of predicting and accounting for intra-and postoperative oedema. 49 The ultimate aims of prostate brachytherapy, and indeed all curative modalities of prostate cancer, remain the same today as almost a century ago that is to treat the prostate cancer but cause as little harm as possible. 9 We now understand that increasing radiation dose beyond a certain threshold leads to negligible benefit.…”