Prostate Cancer-Targeted Imaging Using Magnetofluorescent Polymeric Nanoparticles Functionalized with Bombesin

Lee, Chang-Moon; Jeong, Hwan-Jeong; Cheong, Su-Jin; Kim, Eun‐Mi; Kim, Dong Wook; Lim, Sungjoon; Sohn, Myung‐Hee

doi:10.1007/s11095-010-0072-3

Cited by 62 publications

(37 citation statements)

References 34 publications

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“…Moreover, bombesin, a 14-amino acid peptide binding to the bombesin receptor, has been studied for therapy of gastric-releasing peptide receptor (GRPR)-positive tumors. Bombesin conjugated to N-acetyl histidinemodified GC nanoparticles were able to bind to prostate cancer cells (PC-3) overexpressing GRPR, and iron oxide-loaded nanoparticles could be applied as a probe for magnetic resonance imaging (MRI) [34]. [35].…”

Section: Active Targetingmentioning

confidence: 99%

“…To assess biodistribution of nanoparticles, fluorescent images 146 J.Y. Yhee et al are acquired at various time points up to 72 h post-injection using various photon counting scanners such as eXplore Optix system [9,16], the IVIS Spectrum smallanimal in vivo imaging system [34], or Kodak Image Station 4000 MM [37]. Although the tumor-homing efficiency of the nanoparticles was somewhat differentiated according to the different characteristics of each nanoparticle, many studies demonstrated that chitosan-based nanoparticles were accumulated in tumors.…”

Section: Optical Imagingmentioning

confidence: 99%

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Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy

Yhee

Koo

Lee

et al. 2011

Advances in Polymer Science

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Chitosan and its derivatives have been widely used for various biomedical applications because of their unique chemical and biological characters. The amine groups in the backbone of chitosan allow chemical modification to change the physical properties of chitosan. Based on hydrophobic or charge interactions with this chitosan polymer backbone, stable self-assembled nanoparticles can be fabricated in aqueous condition. These nanosized structures enable intravenous injection and show large accumulation in tumor tissue, indicating great potential in imaging and drug delivery. The main objective of this review is to introduce various chitosan nanoparticles and their recent applications for tumor diagnosis and therapy.

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Section: Active Targetingmentioning

confidence: 99%

Section: Optical Imagingmentioning

confidence: 99%

Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy

Yhee

Koo

Lee

et al. 2011

Advances in Polymer Science

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“…Both passive targeting, through Enhanced Permeability and Retention (EPR) effect (Decuzzi et al, 2009), and active targeting (Lee et al, 2010a;Liang et al, 2010;Zheng et al, 2012) were exploited in the application of NPs. In the example of passive targeting (EPR effect), Kim and colleagues developed polymeric NPs containing the fluorogenic probe Cy5.5 and the dark quencher BHQ-312, linked together by a peptide sequence specific for a matrix metalloproteinase (MMP) for in vivo tumor imaging .…”

Section: In Vivo Optical Sensingmentioning

confidence: 99%

Polymeric nanoparticles for optical sensing

Canfarotta

Whitcombe

Piletsky

2013

Biotechnology Advances

121

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Nanotechnology is a powerful tool for use in diagnostic applications. For these purposes a variety of functional nanoparticles containing fluorescent labels, gold and quantum dots at their cores have been produced, with the aim of enhanced sensitivity and multiplexing capabilities. This work will review progress in the application of polymeric nanoparticles in optical diagnostics, both for in vitro and in vivo detection, together with a discussion of their biodistribution and biocompatibility.

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“…A Cy5.5 filter set (640 nm for excitation, 700 nm for emission) and a subtraction filter set (600-570 nm for excitation) were used for acquiring the in vivo images. The obtained images were analyzed using Living Image Software (Caliper Life Science) (24). All animal experiments were performed in accordance with the guidelines suggested by the Chonbuk National University Medical School Ethics Committee.…”

Section: Cellular Binding Studies Of Cmbp Conjugation To Ga-atp@spionsmentioning

confidence: 99%

Nonpolymeric Surface–Coated Iron Oxide Nanoparticles for In Vivo Molecular Imaging: Biodegradation, Biocompatibility, and Multiplatform

et al. 2013

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A new approach to the surface engineering of superparamagnetic iron oxide nanoparticles (SPIONs) may encourage their development for clinical use. In this study, we demonstrated that nonpolymeric surface modification of SPIONs has the potential to be an advanced biocompatible contrast agent for biomedical applications, including diagnostic imaging in vivo. Methods: Adenosine triphosphate (ATP), which is an innate biomaterial derived from the body, was coated onto the surface of SPIONs. An in vivo degradation study of ATP-coated SPIONs (ATP@SPIONs) was performed for 28 d. To diminish phagocytosis, ATP@SPIONs were surface-modified with gluconic acid. We next studied the ability of the SPIONs to serve as a specific targeted contrast agent after conjugation of cMet-binding peptide. The SPIONs were conjugated with Cy5.5 and labeled with 125 I for multimodality imaging. In vivo and in vitro tumor-targeted binding studies were performed on U87MG cells or a U87MG tumor model using animal SPECT/CT, an optical imaging system, and a 1.5-T clinical MR scanner. Results: ATP@SPIONs showed rapid degradation in vivo and in vitro, compared with ferumoxides. ATP@SPIONs modified with gluconic acid reduced phagocytic uptake, showed improved biodistribution, and provided good targetability in vivo. The gluconic acid-conjugated ATP@SPIONs, when conjugated with cMet-binding peptide, were successfully visualized on the U87MG tumors implanted in mice via multimodality imaging. Conclusion: We suggest that ATP@SPIONs can be used as a multiplatform to target a region of interest in molecular imaging. When we consider the biocompatibility of contrast agents in vivo, ATP@SPIONs are superior to polymeric surface-modified SPIONs.

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Prostate Cancer-Targeted Imaging Using Magnetofluorescent Polymeric Nanoparticles Functionalized with Bombesin

Abstract: These results demonstrate that the BBN conjugation to NAHis-GC nanoparticles improves their tumor accumulation in PC3-bearing mice in comparison to nanoparticles without BBN, suggesting that BC-NAHis-GC nanoparticles may be useful for prostate cancer imaging.

Cited by 62 publications

References 34 publications

Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy

Multifunctional Chitosan Nanoparticles for Tumor Imaging and Therapy

Polymeric nanoparticles for optical sensing

Nonpolymeric Surface–Coated Iron Oxide Nanoparticles for In Vivo Molecular Imaging: Biodegradation, Biocompatibility, and Multiplatform

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