Polymeric nanoparticles for optical sensing

Abstract

Nanotechnology is a powerful tool for use in diagnostic applications. For these purposes a variety of functional nanoparticles containing fluorescent labels, gold and quantum dots at their cores have been produced, with the aim of enhanced sensitivity and multiplexing capabilities. This work will review progress in the application of polymeric nanoparticles in optical diagnostics, both for in vitro and in vivo detection, together with a discussion of their biodistribution and biocompatibility.

Stable biocompatible cross-linked fluorescent polymeric nanoparticles based on AIE dye and itaconic anhydride

“…Cellular fluorescence imaging has attracted much attention as a versatile visualization way for medical diagnosis, drug development, and clinical study [1,2]. Various fluorescent bioprobes have been reported and extensively studied for bioimaging applications over the past decades, among them are green fluorescent protein, semiconductor quantum dots, carbon dots, and organic dye based fluorescent nanoparticles [3][4][5][6].…”

Micro- and nanostructured sol-gel-based materials for optical chemical sensing (2005–2015)

“…A Topical Review by Shi et al in 2014 focused on fluorescent probes and nanoparticles for intracellular sensing of pH [147]. Examples were given of sensors using single molecular probes, quantum dots, metal particles as well as fluorescent polymer and mesoporous sol-gel nanoparticles.…”

“…In recent years, pH sensing in cells has been reported using both polymer and sol-gel nanoparticles. A recent review, already mentioned above, of fluorescent probes and nanoparticles for pH sensing in cells features a range of different fluorescent particles for example quantum dots, carbon nanoparticles as well as polymer and mesoporous silica nanoparticles [147].…”

Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer nanoparticles for direct drug quantification in real biological samples

“…Among them, fluorescent MIPs-based chemosensors are particularly interesting because fluorescence has proven to be a highly powerful transduction mechanism to report the chemical recognition event (due to the easy availability of many fluorescence techniques, their high sensitivity, broad linear range, little sampling, and high simplicity of operation) (Basabe-Desmonts et al, 2007;Canfarotta et al, 2013;Henry et al, 2005;Takeuchi et al, 2005). So far, many fluorescent MIPs-based chemosensors have been designed by incorporating fluorescent components (e.g., organic fluorescent moieties or inorganic quantum dots) into MIPs for the sensitive and label-free detection of a wide range of analytes (Awino and Zhao, 2014;Banerjee and König, 2013;Chao et al, 2014;Huy et al, 2014;Ivanova-Mitseva et al, 2012;Li et al, 2010;Tan et al, 2014;Ton et al, 2013;Turkewitsch et al, 1998;Wan et al, 2013;Wei et al, 2014;Wu et al, 2015;Yang et al, 2012;Zhang et al, 2014;Zhao et al, 2012).…”