Efficient one-pot synthesis of hydrophilic and fluorescent molecularly imprinted polymer nanoparticles for direct drug quantification in real biological samples

Niu, Hui; Yang, Yaqiong; Zhang, Huiqi

doi:10.1016/j.bios.2015.06.071

Cited by 76 publications

(39 citation statements)

References 44 publications

(52 reference statements)

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Section: Analytical Applications Of Mip Nanoparticlesmentioning

confidence: 99%

“…The preparation of MIP sensors based on fluorescence properties has attracted increasing attention in the last years [ 69 , 70 , 71 ]. In 2015, a hydrophilic fluorescent MIP nanoparticle was prepared via a one-pot synthesis approach to determine drugs in biological (bovine and pig serum) samples [ 69 ]. The MIP nanoparticles consisted of a fluorescent core, which was formed by a fluorescent monomer (2-hydroxyethylanthrancene-9-carboxylate)methacrylate, AnHEMA), a functional monomer (MAA), a cross-linking monomer (EGDMA), and the template (tetracycline), and a surface grafted with poly(2-hydroxyethyl methacrylate) (poyHEMA) brushes, which gave rise to highly hydrophilic nanoparticles.…”

Section: Analytical Applications Of Mip Nanoparticlesmentioning

confidence: 99%

“…The samples from left to right in each figure are the ungrafted tetracycline-imprinted polymer (1)/non-imprinted polymer nanoparticles (2) and grafted tetracycline-imprinted polymer (3)/non-imprinted polymer nanoparticles (4). Reproduced with permission from [ 69 ].…”

Section: Schemesmentioning

confidence: 99%

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Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

2020

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In recent years, molecularly imprinted polymers (MIPs) have become an excellent solution to the selective and sensitive determination of target molecules in complex matrices where other similar and relative structural compounds could coexist. Although MIPs show the inherent properties of the polymers, including stability, robustness, and easy/cheap synthesis, some of their characteristics can be enhanced, or new functionalities can be obtained when nanoparticles are incorporated in their polymeric structure. The great variety of nanoparticles available significantly increase the possibility of finding the adequate design of nanostructured MIP for each analytical problem. Moreover, different structures (i.e., monolithic solids or MIPs micro/nanoparticles) can be produced depending on the used synthesis approach. This review aims to summarize and describe the most recent and innovative strategies since 2015, based on the combination of MIPs with nanoparticles. The role of the nanoparticles in the polymerization, as well as in the imprinting and adsorption efficiency, is also discussed through the review.

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Section: Analytical Applications Of Mip Nanoparticlesmentioning

confidence: 99%

Section: Analytical Applications Of Mip Nanoparticlesmentioning

confidence: 99%

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Molecularly Imprinted Polymer Micro- and Nano-Particles: A Review

2020

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“…The MIPs can rebind the template with high selectivity due to the complementarity of binding sites and template in shape, size, and functionality . Their high binding affinity, chemical stability, low cost, and easy preparation make them widely used in many applications, such as solid‐phase extraction, chemical sensors, antibody mimics, and drug delivery systems …”

Section: Introductionmentioning

confidence: 99%

“…The products exhibited good compatibility with water and high affinity to tetracycline . Zhang et al used 2 kinds of monomers to synthesize hydrophilic and fluorescent MIPs for the determination of tetracycline in biological media . For a given template molecule, functional monomer, and cross‐linker, the solvent is an important factor to influence the morphology and binding capacity of MIPs .…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac

Zheng

Wang

Cheng

2018

Polymers for Advanced Techs

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In this study, a series of imprinted poly(methacrylic acid-co-ethylene glycol dimethacrylate) nanocarriers for diclofenac and corresponding nonimprinted polymer nanocarriers have been synthesized in 4 different types of solvents by precipitation polymerization. The products were characterized by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and Brunauer-Emmett-Teller measurement. Results showed that uniformly sized molecularly imprinted polymer (MIP) nanospheres with relatively good porosity could only be obtained in acetonitrile. The effects of solvents on the recognition and release properties of polymer particles were also carefully investigated. The binding experiments indicated that MIPs prepared in acetonitrile displayed much higher binding capacity than other MIPs with a maximum binding capacity of 65.18 mg g −1 . The Scatchard analysis showed that synthetic MIPs have special recognition sites for diclofenac, while nonimprinted polymers have not. The Sips model could provide a best fit to the equilibrium data of nanocarriers over whole concentrations. The experimental data of an adsorption kinetic study were well fitted to the pseudo-second-order kinetic model, indicating the chemisorption mechanism between diclofenac and MIPs in the process of adsorption. The drug release of diclofenac from MIPs could well be described by the Ritger-Peppas model, suggesting a non-Fickian diffusion mechanism. In addition, we successfully used MIPs to extract diclofenac at low levels from fetal bovine serum.

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