Prostate-specific antigen kallikrein and acute myocardial infarction: Where we are. Where are we going?

p2PSA but not total and free PSA increases after myocardial infarction: Results of a preliminary investigation

“…At variance with previous studies, which reported that PSA values either increase or decrease after an AMI [2,3], the results of this preliminary investigation suggest that p2PSA might increase after AMI, whereas the concentrations of both tPSA and fPSA remain mostly unchanged. Notwithstanding the limited number of subjects studied, which precludes to draw definitive conclusions on this topic, the relationship between AMI and prostate biology is an appealing area of research that merits further scrutiny in larger clinical trials.…”

“…Some previous studies have reported contradictory evidence about the kinetics of total prostate-specific antigen (tPSA) after an acute myocardial infarction (AMI), observing either increased or decreases value [1][2][3]. No information is also available on the behaviour of free PSA (fPSA) and especially on the novel prostate cancer biomarker PSA isoform p2PSA [4] in patients with AMI, to the best of our knowledge.…”

ST-segment elevation and diminution of prostate-specific antigen in a patient with coronary spasm and without significant coronary stenoses

“…Apparently spurious result has been reported in a work about mean serum PSA concentration during acute myocardial infarction(AMI) with mean serum PSA concentration significantly lower on day 2 than either day 1 or day 3 and it has been reported that these preliminary results could reflect several factors, such as antiinfarctual treatment, reduced physical activity or an acute-phase response [4]. Both elevated [5][6][7][8][9] as well as diminished PSA [10] have been reported during acute myocardial infarction and our preliminary observations [10,11] have concluded that when elevation of PSA occurs during AMI, coronary lesions are frequent and often more severe than when a diminution of PSA occurs. Moreover, our preliminary observations have concluded also that when elevation of prostate-specific antigen occurs during AMI, it seems to relate to a higher occurrence of major adverse cardiac events in the first 8 days after AMI than when a diminution of PSA occurs [11].…”

“…Both elevated [5][6][7][8][9] as well as diminished PSA [10] have been reported during acute myocardial infarction and our preliminary observations [10,11] have concluded that when elevation of PSA occurs during AMI, coronary lesions are frequent and often more severe than when a diminution of PSA occurs. Moreover, our preliminary observations have concluded also that when elevation of prostate-specific antigen occurs during AMI, it seems to relate to a higher occurrence of major adverse cardiac events in the first 8 days after AMI than when a diminution of PSA occurs [11]. We present a case of STsegment elevation in a patient with diminution of PSA, coronary spasm and without significant coronary stenoses.…”

Prostate-specific antigen kallikrein complexes and acute myocardial infarction

“…Increased PSA serum levels have been reported during prolonged cardiopulmonary resuscitation [2,3], cardiac surgery [4], extracorporeal cardiopulmonary bypass [5,6], cardiogenic shock due to acute myocardial infarction (AMI) [7] and AMI [8][9][10][11][12][13]. However, the finding of diminished PSA during AMI and the correlation of variation of PSA with coronary lesions and occurrence of major adverse cardiac events have opened a possible new intriguing scenario [14,15]. Lately, also a case of diminution of PSA has been reported in a patient with coronary spasm and without significant coronary stenoses [16].…”