Prostate-specific Membrane Antigen–radioguided Surgery Facilitates Pelvic Lymph Node Dissection During Radical Prostatectomy for the Treatment of Locally Advanced Prostate Cancer with Regional Lymph Node Metastases

Prostate-Specific Membrane Antigen–Targeted Radioguided Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients with a Suspicion of Locoregional Lymph Node Metastases: The DETECT Trial

“…From a clinical perspective, we focused specifically on 18 F-PSMA PET-suggestive LNs, and the primary objective was to detect those lesions during 111 In-PSMA RGS, irrespective of histopathologic results. A similar objective was recently described by Lunger et al (23), who reported that PSMA RGS successfully facilitated resection of 70 of 78 (90%) 18 F-PSMA PET-suggestive lesions in 35 patients. Of note, the reported SUV max for 18 F-PSMA PET-suggestive target lesions was considerably higher than in our series.…”

Radioguided surgery for lymph node metastases in prostate cancer

“…In a study by Lunger et al [10] published in Eur Urol Oncol in February 2023, the authors discussed the application of PSMA-RGS during open radical prostatectomy. Their findings underscored the efficacy of this approach in resecting PSMA-positive lymph nodes, even those located beyond the conventional dissection template, thereby potentially improving treatment outcomes [10].…”