Prostatic Carcinoma: A Nutritional Disease? Conflicting Data From the Kingdom of Saudi Arabia

Hanash, Kamal A.; Al-Othaimeen, Abdulaziz I.; Kattan, Said; Lindstedt, E; Alzahrani, Hassan M.; Merdad, Talal; Peracha, Amjad; Kardar, Abdul Hafeez; Aslam, Muhammad; Al-Akkad, Arwa

doi:10.1097/00005392-200011000-00025

Cited by 10 publications

(15 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Screening for prostate cancer is in its infancy in Kuwait, as in other Arab countries, because of the very low incidence of the disease in this region [6–8]. Thus, of the 1700 PSA estimations, only 9.2% were requested for patients with no prostatic symptoms, but as screening for prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High serum prostate‐specific antigen levels in the absence of prostate cancer in Middle‐Eastern men: the clinician's dilemma

Kehinde¹,

Sheikh²,

Mojimoniyi

et al. 2003

BJU International

View full text Add to dashboard Cite

study were men of Arab origin residing in Kuwait. RESULTSIn all, 1700 men (mean age 55.6 years, range 35-94) were assessed; of these, 161 had a serum PSA of >10 ng/mL, attributable to benign prostatic hyperplasia (BPH) in 110 (68%), BPH with histological features of prostatitis in 33 (21%) and prostate cancer in 18 (11%). TRUS of the prostate in 143 of the 161 men with either BPH or BPH with prostatitis showed varying grades of intraprostatic calcifications in 22 (15%). Both PSA density and percentage free PSA did not contribute to determining the causes of total PSA levels of >10 ng/mL. There was a progressive decline in PSA in all patients with BPH and prostatitis, except one who at rebiopsy had prostate cancer (T1N0M0, G1). CONCLUSIONTotal PSA values of >10 ng/mL in Arab men may be a result of BPH, BPH with prostatitis or prostate cancer, in that order. A gradual decline in total PSA (decreased PSA velocity) with time to <4 ng/mL often confirms the diagnosis of BPH with prostatitis. The percentage of free PSA and PSA density may not be helpful in diagnosing prostate cancer with certainty in these patients. Compared with Caucasians in the USA and Europe, BPH and BPH with prostatitis appear to be more frequent causes of serum PSA levels of >10 ng/mL in Arab men.

show abstract

Section: Discussionmentioning

confidence: 99%

“…In the Middle East, the incidence of prostate cancer is relatively low [6–8], but the disease is being increasingly encountered by urologists in the region. The present study investigated Arab men with a serum tPSA of> 10 ng/mL, to determine the proportion who had underlying prostate cancer.…”

Section: Introductionmentioning

confidence: 99%

High serum prostate‐specific antigen levels in the absence of prostate cancer in Middle‐Eastern men: the clinician's dilemma

Kehinde¹,

Sheikh²,

Mojimoniyi

et al. 2003

BJU International

View full text Add to dashboard Cite

show abstract

“…This was a large cohort (20,316) of multiethnic men living in Hawaii with 9 to 14 yr of follow-up and 198 cases of prostate cancer (216). Exactly why prospective cohort studies have not confirmed the international data showing a strong relationship between fat consumption and prostate cancer is unclear but might relate to evidence that other dietary components such as fruits, vegetables, fiber, and cereals may have beneficial effects, independent of fat intake (132) and/or due to lack of variability in dietary fat consumption. Another possibility is a variation in the type of fat consumed.…”

Section: Cancermentioning

confidence: 99%

Effects of exercise and diet on chronic disease

Roberts¹,

Barnard²

2005

Journal of Applied Physiology

474

270

View full text Add to dashboard Cite

Currently, modern chronic diseases, including cardiovascular diseases, Type 2 diabetes, metabolic syndrome, and cancer, are the leading killers in Westernized society and are increasing rampantly in developing nations. In fact, obesity, diabetes, and hypertension are now even commonplace in children. Clearly, however, there is a solution to this epidemic of metabolic disease that is inundating today's societies worldwide: exercise and diet. Overwhelming evidence from a variety of sources, including epidemiological, prospective cohort, and intervention studies, links most chronic diseases seen in the world today to physical inactivity and inappropriate diet consumption. The purpose of this review is to 1) discuss the effects of exercise and diet in the prevention of chronic disease, 2) highlight the effects of lifestyle modification for both mitigating disease progression and reversing existing disease, and 3) suggest potential mechanisms for beneficial effects.

show abstract

“…In Saudi Arabia, the incidence of PCa was documented at 3AE1 ⁄ 100 000 personyears in the year 2000 [1]. Although considered low, the recent rise in the prevalence of obesity and metabolic syndrome in the kingdom [2,3], which are considered modifiable risk factors for PCa aggressiveness, as well as the ageing of the population, may lead to increased incidence for this type of malignancy in the years to come.…”

Section: Introductionmentioning

confidence: 99%

Visceral obesity and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy men

Alokail

Al-Daghri²,

Al‐Attas³

et al. 2011

European Journal of Clinical Investigation

View full text Add to dashboard Cite

show abstract

Prostatic Carcinoma: A Nutritional Disease? Conflicting Data From the Kingdom of Saudi Arabia

Abstract: The incidence of prostatic carcinoma in the Kingdom of Saudi Arabia is low despite a high saturated fat diet in recent years. This finding contradicts most western clinical studies, which indicate a positive association of a high fat diet with prostatic carcinoma.

Cited by 10 publications

References 13 publications

High serum prostate‐specific antigen levels in the absence of prostate cancer in Middle‐Eastern men: the clinician's dilemma

High serum prostate‐specific antigen levels in the absence of prostate cancer in Middle‐Eastern men: the clinician's dilemma

Effects of exercise and diet on chronic disease

Visceral obesity and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy men

Contact Info

Product

Resources

About