Prosthetic joint infection caused by Trueperella bernardiae

Gilarranz, Raúl; Chamizo, Francisco; Horcajada, Iballa; Bordes-Benítez, Ana

doi:10.1016/j.jiac.2016.02.003

Cited by 20 publications

(18 citation statements)

References 11 publications

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“…Given the paucity of susceptibility data, minimum inhibitory concentration interpretive criteria for the genus Corynebacterium can be extrapolated to Arcanobacterium ( Trueperella ) species for interpretation [ 22 ]. Effective treatment of osteoarticular infections caused by Trueperella species has consisted of fluoroquinolones [ 20 , 23 ] and clindamycin [ 9 , 21 ] for durations of 2 to 12 weeks. Our patient was successfully treated with a two-week course of doxycycline which, to our knowledge, has also not been reported in the medical literature.…”

Section: Discussionmentioning

confidence: 99%

“…In summary, we report a case of olecranon bursitis caused by T. bernardiae in a diabetic patient with pseudogout. T. bernardiae has been reported in osteoarticular infections, including prosthetic joint infections [ 20 , 23 ], septic arthritis [ 21 ], and osteitis [ 9 ]. However, to our knowledge, this is the first reported case of olecranon bursitis caused by this organism.…”

Section: Discussionmentioning

confidence: 99%

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Successful Treatment of Olecranon Bursitis Caused byTrueperella bernardiae: Importance of Environmental Exposure and Pathogen Identification

Gowe

Parsons

Best

et al. 2018

Case Reports in Infectious Diseases

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A livestock farmer with a history of arthropathy presented with unilateral olecranon bursal swelling and tenderness. Multiple wound and intraoperative cultures revealed growth of Trueperella bernardiae, a Gram-positive coccobacillus, with symptom resolution following appropriate antimicrobial therapy. To our knowledge, this is the first case report of olecranon bursitis caused by this organism. Coryneform bacteria are often regarded as contaminants in clinical cultures, but advanced techniques for species identification may reveal expanded pathogenic potential of individual species like T. bernardiae and elucidate epidemiologic clues for osteoarticular infections in these cases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Olecranon Bursitis Caused byTrueperella bernardiae: Importance of Environmental Exposure and Pathogen Identification

Gowe

Parsons

Best

et al. 2018

Case Reports in Infectious Diseases

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“…However, the dynamic one retains bone mass and has relatively flexible knee joint, so that it can prevent soft tissue contracture and patella baja and help later prosthesis implantation and rapid preoperative recovery (12). In TKA failure cases, the daily habits of patients also count, and preoperative blood glucose control, cardiopulmonary function improvement, stopping smoking, weight control and lymphedema treatment can reduce the occurrence of infection (13). …”

Section: Discussionmentioning

confidence: 99%

Evaluation of the role of human β-defensin 3 in modulation of immunity and inflammatory response after knee replacement

Jia¹,

Peng²,

Chen³

2017

Experimental and Therapeutic Medicine

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The present study investigated the value of human β-defensin 3 (HBD-3) in adjusting the immunity and inflammatory response of T lymphocytes in the body after knee replacement. Sixty-four cases of knee replacement patients were successively selected and randomly divided into the control group and the observation group each with 32 cases. Once a day, for 7 days, patients in the control group were injected with placebo saline solution in the articular cavity. Levels of Th1 and/Th2, interleukin (IL)-2 and IL-10, tumor necrosis factor (TNF)-α, toll-like receptor (TLR)-4, and alkaline phosphatase (ALP) were compared one month later, and implant infection rates were compared within 1-year follow-up. Compared with patients in the control group, the levels of Th1 and Th1/Th2 in the observation group significantly increased, yet their Th2 decreased. The levels of IL-2 and TNF-α were also observed to be significantly elevated, yet IL-10 decreased. Furthermore, their TLR-4 and ALP levels were significantly higher. Three cases of implant-related infection occurred in the control group and 1 case in the observation group. In conclusion, HBD-3 could adjust the immunity and inflammatory response of cells in the body after knee replacement, possibly playing an important role in implant-related infection.

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“…bernardiae is a gram-positive bacillus that forms part of the normal microbiota of human skin and the oropharynx. Few cases of infection due to this microorganism in pure culture have been reported until now (4)(5)(6)(7)(8)(9)(10)(11)(12), and 5 additional cases have been reported as causing mixed infections ( Table 1). The true incidence of infections with this bacterium is unknown because when isolated in clinical samples, these coryneform bacteria are not identified.…”

Section: Infections Due To Trueperella Bernardiaementioning

confidence: 99%