Protamine-carboxymethyl cellulose magnetic nanocapsules for enhanced delivery of anticancer drugs against drug resistant cancers

Efficacious Doxorubicin Delivery Using Glutathione‐Responsive Hollow Non‐phospholipid Vesicles Bearing Lipoyl Cholesterols

“…This enhancement in cellular DOX fluorescence was also quantified from the micrographs obtained from three independent experiments, which demonstrated almost doubled mean fluorescence intensity of DOX in DR‐HeLa cells treated with vesicles (Figure S10). This distinct activity of drug‐loaded vesicles in DR‐HeLa cells was also evaluated 4 h post‐treatment and it was observed that CL1V–DOX or CL2V–DOX treatment led to clearly visible intracellular DOX fluorescence, whereas treatment with the free drug did not cause cells to fluoresce (Figure 6a1 and a) . This can be plausibly ascribed to the ability of nanocarriers to bypass the drug‐efflux pumps on the membrane of drug‐resistant cells, which results in an increased intracellular concentration of drug .…”

“…This distinct activity of drug-loaded vesicles in DR-HeLa cells was also evaluated 4h post-treatment and it waso bserved that CL1V-DOX or CL2V-DOX treatment led to clearly visible intracellular DOX fluorescence, whereas treatment with the free drug did not cause cells to fluoresce (Figure 6a1 and a2). [38] This can be plausibly ascribed to the ability of nanocarrierst ob ypass the drugefflux pumps on the membrane of drug-resistant cells, which results in an increased intracellular concentration of drug. [7,38] The drug internalisations tudya lso helped in understanding the observed cytotoxicity against both drug-sensitive and drug-resistant cancerc ells, which apparently relied upon the intracellular accumulation of drug.…”

“…[38] This can be plausibly ascribed to the ability of nanocarrierst ob ypass the drugefflux pumps on the membrane of drug-resistant cells, which results in an increased intracellular concentration of drug. [7,38] The drug internalisations tudya lso helped in understanding the observed cytotoxicity against both drug-sensitive and drug-resistant cancerc ells, which apparently relied upon the intracellular accumulation of drug. [20a, 38] Based on these observations,i tc an be suggestedt hat the lipoyl cholesterols could be used to form redox-sensitive vesiclesh aving excellent potential for being exploiteda sd rug delivery vehicles, especially in cases of drug resistance.…”

Opportunities and challenges of the interdisciplinary research of high magnetic fields and life sciences & healthcare

“…印度科技大学制备 了新型铁磁性纳米胶囊, 用来将药物递送到已经产生耐药 性的细胞中, 在外加磁场作用下, 磁性纳米胶囊在细胞中 进行浓聚, 而且动物实验发现强磁场也可以辅助纳米胶囊 在体内进行可控的分布. 因此, 强磁场可以用来辅助将载 药的磁性纳米材料靶向递送到多耐药性的肿瘤细胞中, 释 放药物, 达到促进肿瘤细胞凋亡的作用 [36] . [37] , Markov 团队 [38] 发现磁场可 以促进组织的愈合过程, 同时强磁场在肿瘤热疗中的应用 也是国内外的研究热点 [39] .…”

TAT Peptide-Conjugated Magnetic PLA-PEG Nanocapsules for the Targeted Delivery of Paclitaxel: In Vitro and Cell Studies

“…Recently, magnetic drug targeting of the anticancer agent 5-fluorouracil was combined with ultrasound irradiation of tumors in order to effectively inhibit the growth of CT26 tumors in mice (14). Recently also, polyelectrolyte multilayered nanocapsules modified with Fe 3 O 4 nanoparticles were developed for the delivery of doxorubicin, and they were shown to be more effective than free drug against multidrug-resistant tumor cells when the tumor cells were exposed to an external magnetic field (15).…”