Protease-activated receptor 4-mediated Ca2+ signaling in mouse lung alveolar epithelial cells

Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation

“…5A,C). Because the PAR4 (F2RL3) receptor is also expressed in type II cells (Ando et al, 2007), IP 3 receptormediated Ca 2+ release can be induced by a PAR4 agonist peptide (sequence AYPGKF). TRIC-B-knockout type II cells also exhibited weakened PAR4 agonist-evoked Ca 2+ transients (see Fig.…”

Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells

“…However, contribution of another thrombin receptor, PAR 4 , has not been examined. In our recent study, PAR 4 (mRNA/protein) has been demonstrated to be highly expressed in primary cultured mouse alveolar epithelial cells [7]. This enabled us to test the involvement of PAR 4 stimulation in pathogenetic mechanisms of fibrosis in vitro.…”

Intracolonic infusion of fecal supernatants from ulcerative colitis patients triggers altered permeability and inflammation in mice

“…4 The highest level of PAR 4 mRNA were detected in the lung, pancreas, thyroid, and intestine. 5 Northern blot analysis has shown that mRNA encoding PAR 4 is present in human small and large intestine as well as is functionally expressed in rat and mice colon.…”

“…9 So far, PAR 4 agonist has been shown to stimulate the release of inflammatory mediators, such as interleukin (IL)-6 and IL-8 in human respiratory epithelial cell lines. 5 PAR 4 was demonstrated as a factor involved in activation in inflammatory processes, such as the generation of edema and inflammatory cell recruitment. 10 It has been shown earlier that the activity of serine proteases, which are able to activate PARs, are higher in fecal supernatants from UC patients in comparison with healthy subjects.…”