Background: Proteinase-activated receptors (PARs; PAR 1-4 ) that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of various pulmonary diseases including fibrosis. Among these PARs, especially PAR 4 , a newly identified subtype, is highly expressed in the lung. Here, we examined whether PAR 4 stimulation plays a role in the formation of fibrotic response in the lung, through alveolar epithelialmesenchymal transition (EMT) which contributes to the increase in myofibroblast population.

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Background. Case. Conclusion.