This chapter delves into the dynamic relationship between Systems Thinking and Design Thinking, two influential methodologies reshaping the landscape of innovation. Beginning with an introduction to both approaches, the chapter explores their historical contexts, diverse applications across industries, and prominent models. Design Thinking is elucidated first, highlighting its emphasis on empathetic problem-solving, ideation, and prototyping through tools such as user personas and journey mapping. Meanwhile, systems thinking is characterized by its holistic perspective, focusing on comprehending complex interrelationships and patterns within systems, utilizing tools like causal loop diagrams and system maps for analysis. The chapter proceeds to compare and contrast these two methodologies, ultimately revealing a compelling fusion of their principles. It demonstrates how systems thinking adeptly identifies opportunities within intricate systems, which seamlessly transitions into the realm of Design Thinking for implementing transformative changes and creating ventures. This integrated approach provides a comprehensive framework—leveraging systems thinking for opportunity identification and Design Thinking for impactful implementation—offering a holistic guide for navigating and innovating within complex systems.