Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization

Wang, Yule; Xiao, Guangxu; He, Shuang; Li, Xinyan; Zhu, Lin; Yang, Xinyue; Zhang, Yiqian; Orgah, John; Feng, Yi; Wang, Xiaoying; Zhang, Boli; Zhu, Yan

doi:10.1016/j.biopha.2020.109945

Cited by 70 publications

(35 citation statements)

References 85 publications

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“…Recently, the major active ingredients in QSYQ, such as astragaloside IV, calycosin, calycosin-7-O-β-D-glycoside, formononetin, salvianolic acid A, salvianolic acid B, tanshinone IIA, notoginsenoside R1, ginsenoside Rg1, and ginsenoside Rb1 (Yu et al, 2017;Zhang et al, 2018), have been reported to have therapeutic potential in acute and subacute phases of ischemic stroke via various functional mechanisms, especially immune-inflammatory response related mechanism (Han et al, 2017b;Zhang et al, 2020). Furthermore, we have found the protective action of QSYQ against acute ischemic stroke via regulating neuroinflammatory network mobilization in a mouse model of cerebral ischemia and reperfusion (Wang et al, 2020).…”

Section: Introductionmentioning

confidence: 77%

“…At present, QSYQ with the function of Qi-tonifying and blood-activating has been widely used to treat cardiovascular disease in clinic (Han et al, 2019). In addition to the cardioprotection against ischemia/reperfusion injury, we recently also reported the protective effect of pretreatment with QSYQ against CI/RI, which may be partly related to the modulation of neuroinflammatory response in an acute stroke model (Chen et al, 2015;Wang et al, 2020). However, questions remain on whether QSYQ contributes to the therapeutic post-stroke recovery and, if so, what the underlying mechanisms are.…”

Section: Discussionmentioning

confidence: 98%

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Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model

Wang

et al. 2021

Front. Pharmacol.

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Effective therapies for stroke are still limited due to its complex pathological manifestations. QiShenYiQi (QSYQ), a component-based Chinese medicine capable of reducing organ injury caused by ischemia/reperfusion, may offer an alternative option for stroke treatment and post-stroke recovery. Recently, we reported a beneficial effect of QSYQ for acute stroke via modulation of the neuroinflammatory response. However, if QSYQ plays a role in subacute stroke remains unknown. The pharmacological action of QSYQ was investigated in experimental stroke rats which underwent 90 min ischemia and 8 days reperfusion in this study. Neurological and locomotive deficits, cerebral infarction, brain edema, and BBB integrity were assessed. TMT-based quantitative proteomics were performed to identify differentially expressed proteins following QSYQ treatment. Immunohistochemistry, western blot analysis, RT-qPCR, and ELISA were used to validate the proteomics data and to reveal the action mechanisms. Therapeutically, treatment with QSYQ (600 mg/kg) for 7 days significantly improved neurological recovery, attenuated infarct volume and brain edema, and alleviated BBB breakdown in the stroke rats. Bioinformatics analysis indicated that protein galectin-3 and its mediated inflammatory response was closely related to the beneficial effect of QSYQ. Specially, QSYQ (600 mg/kg) markedly downregulated the mRNA and protein expression levels of galectin-3, TNF-α, and IL-6 in CI/RI brain as well as serum levels of TNF-α and IL-6. Overall, our findings showed that the effective action of QSYQ against the subacute phase of CI/RI occurs partly via regulating galectin-3 mediated inflammatory reaction.

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Section: Introductionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 98%

Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model

Wang

et al. 2021

Front. Pharmacol.

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“…Inflammation is a complex biological process in the body in response to cell and tissue damage (Chen et al, 2017). The definition of neuroinflammation is an inflammatory process within the brain or spinal cord (DiSabato et al, 2016;Wang Y. et al, 2020). Neuroinflammation is a common feature in many neurological diseases such as brain trauma, stroke, multiple sclerosis (MS), Alzheimer's disease (AD), and Parkinson's disease (PD) (Stephenson et al, 2018).…”

Section: Cellular and Molecular Responses To Brain Injuries Inflammatory Responsementioning

confidence: 99%

Neurorepair and Regeneration of the Brain: A Decade of Bioscaffolds and Engineered Microtissue

Zamproni

Mundim

Porcionatto

2021

Front. Cell Dev. Biol.

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Graphical AbstractBioscaffolds potential applications in tissue engineering. Bioscaffolds can be used to grow stem cells and target their differentiation in vitro(upper, left) or be used as stem cell delivery route in a brain injury (upper, right). Bioscaffolds can also contain si/miRNAs that will modify locally neural cells gene expression (lower, left) or contain exosomes/growth factors for paracrine signaling such as stimulating neurogenesis and increase neural stem migration to injury area (lower, right). This cover has been designed using resources created by Vitaly Gorbachev from Flaticon.com.

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“…For example, the study from Wang B et al, which was totally cited 112 times, illustrated that low-concentration CO manifested a neuroprotective effect on cerebral ischemia by activating the Nrf2 pathway [27]. One of the special contributions of China was the exploration of the neuroprotective effect of traditional Chinese medicine, such as Sanhua Decoction and QiShenYiQi [28,29]. Many trials about neuroprotection failed to translate their protective effects from animal models to humans.…”

Section: The Research Trend Of Cerebrovascular Intervention In Chinamentioning

confidence: 99%

Bibliometric Analysis of China’s Contribution to the Knowledge System of Cerebrovascular Intervention

Liu

et al. 2021

Preprint

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Background: Cerebrovascular disease has become the leading cause of death in China. The purpose of this article is to analyze China’s contribution to interventional treatment of cerebrovascular diseases. Methods: Bibliometric analysis was used for evaluating the quantity, quality, research hotspots, and cooperation network of publications from China. Articles were acquired from the database of Web of Science Core Collection. The authors, publication years, citation times, original regions, and source journals were recorded by EXCEL 2019. Network analysis and visualization were performed on Citespace5.6.Results: From 1991 to 2019, totally 5,052 articles regarding cerebrovascular intervention were published by Chinese researchers. The number of publications from China grew fastest annually in the latest five years among countries. These publications were totally cited 61,216 times, with 12.12 average citations per item. The h-index was 82. Affiliated hospitals of Capital Medical University contributed most articles. Cerebral ischemia and intracranial aneurysm were the most popular keywords over the three decades. The timeline view of keywords indicated that cerebral ischemia was always a hot spot. Stent techniques were the main treatment tools and still had a strong developing trend. Basic researches of cerebrovascular intervention had a preference for neural regeneration and neuroprotection.Conclusions: The number of publications from China grows fast in recent years, but research quality needs further enhancement. The highly targeted researches are continuously promoting the clinical practice of CVDs. More valuable clinical evidence would be provided.

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Protection against acute cerebral ischemia/reperfusion injury by QiShenYiQi via neuroinflammatory network mobilization

Cited by 70 publications

References 85 publications

Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model

Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model

Neurorepair and Regeneration of the Brain: A Decade of Bioscaffolds and Engineered Microtissue

Bibliometric Analysis of China’s Contribution to the Knowledge System of Cerebrovascular Intervention

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