Protection against Amorimia septentrionalis poisoning in goats by the continuous administration of sodium monofluoroacetate-degrading bacteria

Silva, Layze C.A. da; Pessoa, Danielle A.N.; Lopes, José R.G.; Albuquerque, Laio Gomes de; Silva, Leomyr S.A. da; Garino, Felício; Riet-Correa, Franklin

doi:10.1016/j.toxicon.2015.12.016

Cited by 10 publications

(17 citation statements)

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“…The bacteria used in the present study were isolated from soil and from plants containing sodium monofluoroacetate (MFA) and identified as degrading this substance (Camboim et al 2012). These were diluted in 0.9% sodium chloride solution at concentration 1 of the MacFarland scale and the dose used for oral administration in goats was 60mL (Silva et al 2016). The caprine from Group 1 had previously received daily, for 40 days, the solution containing the bacteria Ralstonia sp.…”

Section: Methodsmentioning

confidence: 99%

“…Caprine from Group 2 received for 40 days the solution containing the bacteria Paenibacillus sp. and Cupriavidus sp., and since the 10th day until the 40th day, they also received 5g/kg of A. septentrionalis leaves (Silva et al 2016). Group 3 was composed of goats from areas without the occurrence of A. septentrionalis.…”

Section: Methodsmentioning

confidence: 99%

“…The control and prophylaxis of this poisoning by traditional methods such as fencing infested areas or using herbicides is not efficient (Barbosa et al 2003). Therefore, some studies have already used several alternatives to render ruminants resistant to plant poisoning containing MFA, including: 1) the repeated administration of non-toxic doses of the plant containing MFA for alternate periods (Duarte et al 2014); 2) the transfer of ruminal fluid from ruminants inoculated with MFA-degrading bacteria, which became resistant to poisoning, to susceptible ruminants (Silva et al 2015); 3) the administration of MFA-degrading bacteria isolated from the rumen of animals, soil and plants containing MFA (Pessoa et al 2015, Silva et al 2016; 4) use of the conditioned aversion technique through the use of lithium chloride (Brito et al 2016).…”

Section: Introductionmentioning

confidence: 99%

“…and Burkholderia sp.) are continuously administered together with the plant there is no loss of resistance (Silva et al 2016). The aim of this study was to evaluate whether the resistance to poisoning induced by bacteria that hydrolyze MFA remains when experimentally resistant animals are exposed to natural poisoning by the plant on an ongoing basis.…”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study was to evaluate whether the resistance to poisoning induced by bacteria that hydrolyze MFA remains when experimentally resistant animals are exposed to natural poisoning by the plant on an ongoing basis. Thus, caprine that had been induced resistance to MFA by oral administration of bacteria that hydrolyze this substance (Silva et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of resistance to natural poisoning by Amorimia septentrionalis in goats which had received sodium monofluoroacetate degrading bacteria

et al. 2018

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Amorimia septentrionalis is an important sodium monofluoroacetate (MFA) containing plant that causes sudden death in ruminants in northeastern Brazil. MFA degrading bacteria are being used in the prevention against poisoning by this plant. The aim of this study was to evaluate if goats which had per os received MFA degrading bacteria remained resistant when exposed to natural poisoning by A. septentrionalis. Eighteen goats were randomly distributed into three groups: the goats of Group 1 previously received, during 40 days, a solution containing the bacteria Ralstonia sp. and Burkholderia sp., those goats in the Group 2 received the bacteria Paenibacillus sp. and Cupriavidus sp. and goats from Group 3 did not receive any bacteria. After the administration period, during 60 days, the animals of all groups were released to graze on a one hectare paddock, with significant amount of A. septentrionalis. They were observed daily for the spontaneous consumption of A. septentrionalis leaves and the occurrence of clinical signs of poisoning or sudden death. Goats from all groups consumed significant amounts of A. septentrionalis during the experimental period. Goats that did not receive MFA-degrading bacteria (Group 3) became sick and died from the 25th to the 27th day of the experiment, whereas the goats of the groups that received MFA-degrading bacteria showed only clinical sings when A. septentrionalis regrowth after the 55th day of the experiment. The days elapsed from field observation to death of Group 3 goats (25.5±0.9 days) were significantly lower (p<0.05) than Group 1 (58.6±1.3 days) and Group 2 (57.8±1.5 days). Thus, it can be concluded that administration of MFA degrading bacteria increases the resistance to natural poisoning by A. septentrionalis.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%