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RESUMO.-[Eliminação da toxina tremorgênica de INTRODUCTIONIpomoea asarifolia R. et Schult. (common name: salsa), family Convolvulaceae, is a plant native to South and Central America. In Brazil it is very common in the Amazon region, in the Northeast, and along the coast, from northern Brazil to the southern states of Rio de Janeiro and São Paulo (Kissmann & Groth 1992). I. asarifolia is a tremorgenic plant that causes poisoning in sheep (Döbereiner et al. 1960, Guedes et al. 2007), goats (Döbereiner et al. 1960, Medeiros et al. 2003, Guedes et al. 2007), cattle (Döbereiner et al. 1960, Barbosa et al. 2005) and buffalo (Barbosa et al. 2005). Clinical signs caused by I. asarifolia are similar than those caused by the indole-diterpene mycotoxins produced by different fungi (di Menna et al. 2012, Cawdell-Smith et al. 2010, but the tremorgenic toxin of the plant is unknown.In With the aim to determine if the tremorgenic toxin of Ipomoea asarifolia is eliminated in milk, three groups of Swiss female mice received, immediately after giving birth until weaning, a ration containing 20% or 30% of dry I. asarifolia. All the offspring of the females that received 20% or 30% I. asarifolia showed tremors 2-4 days after birth. The offspring of the females that received 20% I. asarifolia recovered 4-7 days after weaning. The offspring of the females that received 30% of the plant in the ration died while showing tremors before weaning or up to two days after weaning. It is concluded that the tremorgenic compound of I. asarifolia or its toxic metabolites are eliminated in milk, and that lactating mice may be used as a model for the determination of the toxic compound(s) in this plant.

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RESUMO Considerando que os principais sinais clínicos observados na intoxicação por