Administração de diferentes concentrações de folhas de Ipomoea asarifolia na ração de camundongos

Lopes, José R.G.; Riet-Correa, Franklin; Medeiros, Márcia Alves de; Dantas, F.P.M.; Medeiros, Rosane M.T.

doi:10.1590/s0103-84782014000500015

Cited by 7 publications

(7 citation statements)

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“…Apesar de não ser conhecido o principio ativo da I. asarifolia, os sinais clínicos são semelhantes aos de toxinas tremorgênicas, caraterizados por tremores musculares, inicialmente de cabeça e pescoço que posteriormente se generalizam por todo o corpo, culminando com perda de equilíbrio seguido de quedas (Medeiros et al 2003). Também foi determinado em camundongos que o principio ativo ou um metabolito do mesmo tem a capacidade de passar pelo leite intoxicando os filhotes lactentes sem que as mães apresentem sinais (Lopes 2013).…”

Section: Introductionunclassified

Intoxicação por Ipomoea asarifolia em bovinos e ovinos no Rio Grande do Norte

Carvalho¹,

Dantas²,

Riet-Correa³

et al. 2014

Pesq. Vet. Bras.

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Ipomoea asarifolia é uma das principais plantas tóxicas para ruminantes nas regiões Norte e Nordeste. A intoxicação ocorre na época das secas quando há escassez de forragem e é mais frequente em ovinos do que em outras espécies, porem casos espontâneos também são relatados em caprinos, bovinos e búfalos. Este trabalho relata a ocorrência de 18 surtos de intoxicação em bovinos por I. asarifolia que ocorreram de agosto de 2012 a fevereiro de 2013 no estado do Rio Grande Norte. De um total de 1704 bovinos, 202 (11,8%) adoeceram e 34 (2%) morreram. Em seis propriedades onde havia ovinos estes também se intoxicaram. Foram observados também sinais clínicos em bezerros e cordeiros confinados, sem acesso às pastagens, que se intoxicaram pela ingestão do leite das mães que ingeriam I. asarifolia a pasto.

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Section: Introductionunclassified

Intoxicação por Ipomoea asarifolia em bovinos e ovinos no Rio Grande do Norte

Carvalho¹,

Dantas²,

Riet-Correa³

et al. 2014

Pesq. Vet. Bras.

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“…However, Araújo et al (2008) and Freitas et al (2011) failed to induce the disease in lambs and kids consuming milk from ewes and goats ingesting I. asarifolia. In contrast, preliminary studies in mice show that pups of lactating mothers that were ingesting I. asarifolia become intoxicated and show muscle tremors (Lopes, 2013). This study was conducted to determine in sheep if the tremorgenic toxin of I. asarifolia or a toxic metabolite is eliminated in milk thus causing poisoning in the offspring.…”

Section: Introductionmentioning

confidence: 99%

Poisoning by Ipomoea asarifolia in lambs by the ingestion of milk from ewes that ingest the plant

Lucena

Rodrigues

Campos

et al. 2014

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“…With penitren A, the main tremorgenic toxin of Lolium perenne, it was demonstrated that 1-3-day--old mice dosed intraperitoneally were more susceptible than 11-week-old mice (Lu et al 2008). In a previous work, it was observed that dry I. asarifolia mixed 20-30% in the food of 40-day-old mice causes changes in equilibrium and motor coordination, but without tremors (Lopes et al 2014). These results also suggest that newborn mice can be used as an experimental model to study the tremorgenic compound of I. asarifolia.…”

Section: Discussionmentioning

confidence: 99%

“…Behaviour changes without tremors were also observed in weaned of mice ingesting I. asarifolia (Lopes et al 2014). In sheep the poisoning has been observed in nursing lambs that remain confined, without ingesting the plant, while their mothers ingested the plant while grazing without showing signs of disease (Araújo et al 2008, Freitas et al 2011).…”

Section: Introductionmentioning

confidence: 96%

Elimination of the tremorgenic toxin of Ipomoea asarifolia by milk

et al. 2014

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RESUMO.-[Eliminação da toxina tremorgênica de INTRODUCTIONIpomoea asarifolia R. et Schult. (common name: salsa), family Convolvulaceae, is a plant native to South and Central America. In Brazil it is very common in the Amazon region, in the Northeast, and along the coast, from northern Brazil to the southern states of Rio de Janeiro and São Paulo (Kissmann & Groth 1992). I. asarifolia is a tremorgenic plant that causes poisoning in sheep (Döbereiner et al. 1960, Guedes et al. 2007), goats (Döbereiner et al. 1960, Medeiros et al. 2003, Guedes et al. 2007), cattle (Döbereiner et al. 1960, Barbosa et al. 2005) and buffalo (Barbosa et al. 2005). Clinical signs caused by I. asarifolia are similar than those caused by the indole-diterpene mycotoxins produced by different fungi (di Menna et al. 2012, Cawdell-Smith et al. 2010, but the tremorgenic toxin of the plant is unknown.In With the aim to determine if the tremorgenic toxin of Ipomoea asarifolia is eliminated in milk, three groups of Swiss female mice received, immediately after giving birth until weaning, a ration containing 20% or 30% of dry I. asarifolia. All the offspring of the females that received 20% or 30% I. asarifolia showed tremors 2-4 days after birth. The offspring of the females that received 20% I. asarifolia recovered 4-7 days after weaning. The offspring of the females that received 30% of the plant in the ration died while showing tremors before weaning or up to two days after weaning. It is concluded that the tremorgenic compound of I. asarifolia or its toxic metabolites are eliminated in milk, and that lactating mice may be used as a model for the determination of the toxic compound(s) in this plant.

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Administração de diferentes concentrações de folhas de Ipomoea asarifolia na ração de camundongos

Abstract: RESUMO Considerando que os principais sinais clínicos observados na intoxicação por

Cited by 7 publications

References 6 publications

Intoxicação por Ipomoea asarifolia em bovinos e ovinos no Rio Grande do Norte

Intoxicação por Ipomoea asarifolia em bovinos e ovinos no Rio Grande do Norte

Poisoning by Ipomoea asarifolia in lambs by the ingestion of milk from ewes that ingest the plant

Elimination of the tremorgenic toxin of Ipomoea asarifolia by milk

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