Poisoning by Ipomoea asarifolia in lambs by the ingestion of milk from ewes that ingest the plant

Lucena, Kleber F. Carvalho de; Rodrigues, Jussara M.N.; Campos, Édipo Moreira; Dantas, Antônio Flávio Medeiros; Pfister, James A.; Cook, Daniel; Medeiros, Rosane M.T.; Riet-Correa, Franklin

doi:10.1016/j.toxicon.2014.10.019

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…Using mice as an experimental model, Lopes et al (2014) demonstrated that the tremorgenic toxin present in Ipomoea asarifolia, or its metabolite, is eliminated in the milk of females that consume ration containing this plant, causing tremors and even the death of the offspring. Posteriorly, Carvalho de Lucena et al (2014) also confirmed the occurrence of poisoning in lambs that ingested milk from ewes that fed exclusively on I. asarifolia.…”

Section: Discussionsupporting

confidence: 62%

Neonatal mortality associated with sodium monofluoracetate in kids fed with colostrum from goats ingesting Amorimia septentrionalis

et al. 2019

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Sudden deaths after colostrum ingestion in kids and lambs born to mothers grazing in areas with Amorimia septentrionalis have been reported in the Brazilian northeastern semi-arid region, in Paraíba state. This study aimed to determine whether the sodium monofluoracetate (MF) contained in A. septentrionalis is eliminated in milk, causing the death of kids. After confirming gestation on the 25th day after mating, 26 goats were randomly distributed into three groups. In Group 1, eight goats received fresh leaves of A. septentrionalis in daily doses of 1g/kg body weight, administered at three different periods during gestation: from days 91 to 100, 116 to 125, and from day 140 until delivery day. In Group 2, consisting of 10 females, eight goats received 1g/kg body weight of A. septentrionalis dried and milled leaves, fed daily from the 140th day of gestation until delivery. The other two goats of this group did not ingest the plant during gestation and after delivery the colostrum supplied to their kids was replaced by colostrum of goats from that same group that had ingested the plant. Eight goats from Group 3 (control) did not ingest A. septentrionalis. Seven goats from Group 1 showed signs of poisoning from 2nd to 8th days of plant administration, in all periods, and recovered within 7 to 12 days. Another goat presented severe clinical signs and was submitted to euthanasia in extremis. Two goats aborted. Four kids, from two goats, received colostrum and, after 15 minutes, presented depression, breathing wheezing, lateral recumbence, bleating, and death. Two goats gave birth at night; the two kids were found dead and, at necropsy, it was verified that they were born alive. The last goat in this group gave birth to two kids which showed no signs of poisoning after colostrum ingestion. In Group 2, the eight goats that ingested dry leaves of the plant presented tachycardia and engorgement of the jugular veins; six aborted, and the kids of the other two goats died immediately after delivery without ingesting colostrum. The three kids of the two goats that did not ingest the plant during gestation did not show signs of poisoning after ingesting colostrum from the goats that had ingested the plant. In Group 3, all females kidded normally and the kids showed no signs of poisoning. Ten leaf samples of A. septentrionalis contained 0.00074% ±0.00018 MF. These results demonstrate that the MF of A. septentrionalis is eliminated in colostrum and may cause the death of kids. As in previous reports, the plant also caused abortion.

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Section: Discussionsupporting

confidence: 62%

Neonatal mortality associated with sodium monofluoracetate in kids fed with colostrum from goats ingesting Amorimia septentrionalis

et al. 2019

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“…Grazing on morning glories, most frequently on Ipomoea asarifolia and Ipomoea muelleri , may also cause a tremorgenic syndrome on livestock (Gardiner et al 1965; Medeiros et al 2003; Dorling et al 2004; Carvalho de Lucena et al 2014). This toxicosis is also associated with the presence of IDTs (Lee et al 2017), produced by seed-transmitted endophytic fungi, most likely P. ipomoeae (Schardl et al 2013; Lee et al 2017).…”

Section: Idts As Threats To Agriculture Public Health and The Fermementioning

confidence: 99%

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Kozák

Szilágyi

Tóth

et al. 2019

Appl Microbiol Biotechnol

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Indole-diterpenes (IDTs) such as the aflatrems, janthitrems, lolitrems, paspalitrems, penitrems, shearinines, sulpinines, and terpendoles are biogenetically related but structurally varied tremorgenic and neurotoxic mycotoxins produced by fungi. All these metabolites derive from the biosynthetic intermediate paspaline, a frequently occurring IDT on its own right. In this comprehensive review, we highlight the similarities and differences of the IDT biosynthetic pathways that lead to the generation of the main paspaline-derived IDT subgroups. We survey the taxonomic distribution and the regulation of IDT production in various fungi and compare the organization of the known IDT biosynthetic gene clusters. A detailed assessment of the highly diverse biological activities of these mycotoxins leads us to emphasize the significant losses that paspaline-derived IDTs cause in agriculture, and compels us to warn about the various hazards they represent towards human and livestock health. Conversely, we also describe the potential utility of these versatile molecules as lead compounds for pharmaceutical drug discovery, and examine the prospects for their industrial scale manufacture in genetically manipulated IDT producers or domesticated host microorganisms in synthetic biological production systems.

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“…Ipomoea carnea and Ipomoea trifida found in the paddocks were negative for swainsonine, but contained calystegines at 0.02% and 0.06% suggesting that the disease was caused by these substances, which are competitive inhibitors of β-glucosidase and αgalactosidase activities. Balogh et al, 1999;Stegelmeier et al, 1999;Barbosa et al, 2006;Carvalho de Lucena et al, 2014). The main histological lesions found in affected animals consist of vacuolation of the perikaria and axonal dystrophy in neurons of all regions of the nervous system, being more prominent in the Purkinje cells of the cerebellum and in neurons of the cerebellar nuclei, where loss of cells with minimal inflammation is a common feature.…”

Section: Discussionmentioning

confidence: 99%

“…Todas las ovejas intoxicadas tuvieron signos clínicos similares caracterizados por tremor muscular en cabeza y cuello y movimientos laterales de la cabeza. Cuando se les forzaba al movimiento presentaban ataxia con desviación y rigidez de las extremidades (Carvalho de Lucena et al, 2014).…”

Section: Alteraciones Neurológicas Provocadas En Cabras Por El Consumo De Plantas Del Género Ipomoeaunclassified

“…Cuando los animales afectados eran obligados a moverse presentaban ataxia cerebelosa, rigidez de los miembros y posturas inusuales. Generalmente los animales se recuperaban, pero cuando ocurría la muerte no se encontraban lesiones macroscópicas ni microscópicas, aunque en casos de intoxicaciones crónicas se observó degeneración de las células de Purkinje en cerebelo (Carvalho de Lucena et al, 2014).…”

Section: Alteraciones Neurológicas Provocadas En Cabras Por El Consumo De Plantas Del Género Ipomoeaunclassified

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Patologías nerviosas emergentes en caprinos: Louping ill e intoxicación por plantas "Ipomoea" spp” = Emerging nervous pathologies in goats: Louping il and Ipomoea spp poisoning

Rodríguez¹,

Manuel²

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Poisoning by Ipomoea asarifolia in lambs by the ingestion of milk from ewes that ingest the plant

Cited by 12 publications

References 14 publications

Neonatal mortality associated with sodium monofluoracetate in kids fed with colostrum from goats ingesting Amorimia septentrionalis

Neonatal mortality associated with sodium monofluoracetate in kids fed with colostrum from goats ingesting Amorimia septentrionalis

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Patologías nerviosas emergentes en caprinos: Louping ill e intoxicación por plantas "Ipomoea" spp” = Emerging nervous pathologies in goats: Louping il and Ipomoea spp poisoning

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