Protection against avian necrotic enteritis after immunisation with NetB genetic or formaldehyde toxoids

Abstract

HighlightsNetB from Clostridium perfringens is the major virulence factor in avian necrotic enteritis.Vaccination with a NetB genetic or formaldehyde toxoid protects chicken in an in vivo disease model.NetB toxoids could form the bases of an efficient vaccine against necrotic enteritis.

The Probiotic Butyricicoccus pullicaecorum Reduces Feed Conversion and Protects from Potentially Harmful Intestinal Microorganisms and Necrotic Enteritis in Broilers

“…The subclinical form of C. perfringens associated- NE can adversely affects growth rate, feed conversion, and flock uniformity ( Lovland and Kaldhusdal, 2001 ) resulting in serious economic losses on the poultry industry ( Timbermont et al, 2011 ). In addition to the etiological agent C. perfringens , predisposing factors such as Eimeria -induced mucosal damage and diets containing high levels of proteins are required to elicit the clinical signs and lesions of NE in poultry ( Fernandes da Costa et al, 2013 ). Those predisposing factors are hypothesized to change the gastrointestinal microbiota, providing a disrupted intestinal ecosystem in which C. perfringens can proliferate and cause disease ( Wu et al, 2014 ).…”

Alternatives to Antibiotics to Prevent Necrotic Enteritis in Broiler Chickens: A Microbiologist's Perspective

“…Several trials have shown that chickens could be protected against C. perfringens -induced NE by injection with inactive and active toxins (Kulkarni et al, 2007 ; Jang et al, 2012 ) and antigenic proteins (Jiang et al, 2009 ). Since the discovery of its role in NE, the NetB toxin has been intensively studied with regards to vaccination, with some promising results (Fernandes da Costa et al, 2013 ; Keyburn et al, 2013a , b ).…”

Effects of dietary selenium on host response to necrotic enteritis in young broilers

“…The protective effects of Se did not consistently increase proportionally with the increased dose of supplemented Se between 0.25 and 1.00 mg/ kg possibly because the highest dose may be influenced by toxic effects in this particular broiler group. C. perfringens α-toxin and NetB toxin are major virulence factors implicated in the pathogenesis of NE and are considered to be potential vaccine candidates in chickens (Fernandes da Costa et al, 2013;Jang et al, 2012;Sumners et al, 2012). The antibody levels against α-toxin and NetB toxin may be relevant in protective host immunity against C. perfringens .…”