Protection Against Drug-Induced Liver Injuries Through Nutraceuticals via Amelioration of Nrf-2 Signaling

Yousuf, Sumaira; Shabir, Shabnam; Singh, Mahendra P.

doi:10.1080/27697061.2022.2089403

Cited by 13 publications

(8 citation statements)

References 130 publications

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“…According to epidemiological studies, higher intakes of antioxidant-rich vegetables, fruits, and medicinal herbs are linked with a decreased risk of chronic diseases. Since the high level of free radical production affects apoptosis, cell proliferation, and ion transport, it damages lipids, polypeptides, and DNA and contributes to diseases, including hepatotoxicity [ 6 ], cardiovascular disease, carcinogenesis, and neurological disorders [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Nrf2, in its inactive form, resides in the cytosol in association with Kelch-like associating protein-1. In response to oxidative stress, the Nrf2-KEAP1 complex undergoes ubiquitination and translocates to the nucleus, where it starts the transcription of antioxidant enzymes along with enhancer sequences that are antioxidant response elements (AREs) to combat cellular oxidative stress [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Yousuf

Shabir²,

Kauts³

et al. 2022

Molecules

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Natural antioxidants derived from plants have played a vital role in preventing a wide range of human chronic conditions and provide novel bioactive leads for investigators in pharmacotherapy discovery. This work was designed to examine the ethnopharmacological role of Urtica dioica (UD), Capsella bursa-pastoris (CBP), and Inula racemosa (IR). The total phenolic and flavonoid contents (TPC and TFC) were illustrated through colorimetric assays, while the antioxidant activity was investigated through DPPH and ABTS assays. The evaluation of phytochemicals by FT-IR of UD and CBP revealed high contents of aliphatic amines, while IR showed a major peak for ketones. The antioxidant activity, TPC and TFC were highest in the ethanol extract of UD, followed by CBP, and IR showed the lowest activity. All of the extracts revealed significant antioxidant capacities along a dosage gradient. Through a HPLC analysis at a wavelength of 280 nm, UD leaves demonstrated an intense peak of quercetin, and the peak for rutin was less intense. CBP (whole plant), instead, demonstrated a major yield of rutin, and a peak for quercetin was not observed in CBP. IR (rhizomes) showed both quercetin and rutin. All of the extracts were significantly cytotoxic to HepG2 cells after 48 h with the trend IR > UD > CBP. The outcomes of this study may be effective in the selection of specific plants as realistic sources of the bioactive components that might be useful in the nutraceutical progression and other biomedical efficacies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Yousuf

Shabir²,

Kauts³

et al. 2022

Molecules

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show abstract

“…In addition to in vivo imaging of reactive chlorine species (e.g., ClO – ), reactive oxygen and nitrogen species including ONOO – , as another vital constituent of the reactive metabolites during drug metabolism, may be an alternative evaluation indicator in drug-driven liver injury. − As of now, liver injury is still a widespread clinical issue, of which the related pathophysiological mechanism is very complicated and traditional diagnostic methods have inherent practical limitations. In this context, Liu and colleagues completed the design of dual-phosphorescent polymeric probes for exploring drug-induced liver injury by the specific imaging of ONOO – in vivo .…”

Section: Room-temperature Phosphorescence For Biomedical Applicationsmentioning

confidence: 99%

Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Chang,

Chen,

Bao

et al. 2023

Chem. Rev.

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“…Many phytochemicals possess high antioxidant activity. In addition, they target the nuclear factor E2-related factor2/heme oxygenase 1 (NRF2/HO-1) pathway to reduce oxidative stress and inflammation [ 181 , 182 ]. Either high intracellular radical levels—generated either by free heme molecules or dysfunctional mitochondria—or AMPK activation [ 183 ] induce the transcription factor NRF2 and its target genes ferritin and hmox-1 , coding for heme oxygenase 1.…”

Section: Protective Treatmentsmentioning

confidence: 99%

Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented?

Fehsel

2023

Biomedicines

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Impaired iron metabolism has been increasingly observed in many diseases, but a deeper, mechanistic understanding of the cellular impact of altered iron metabolism is still lacking. In addition, deficits in neuronal energy metabolism due to reduced glucose import were described for Alzheimer’s disease (AD) and its comorbidities like obesity, depression, cardiovascular disease, and type 2 diabetes mellitus. The aim of this review is to present the molecular link between both observations. Insufficient cellular glucose uptake triggers increased ferritin expression, leading to depletion of the cellular free iron pool and stabilization of the hypoxia-induced factor (HIF) 1α. This transcription factor induces the expression of the glucose transporters (Glut) 1 and 3 and shifts the cellular metabolism towards glycolysis. If this first line of defense is not adequate for sufficient glucose supply, further reduction of the intracellular iron pool affects the enzymes of the mitochondrial electron transport chain and activates the AMP-activated kinase (AMPK). This enzyme triggers the translocation of Glut4 to the plasma membrane as well as the autophagic recycling of cell components in order to mobilize energy resources. Moreover, AMPK activates the autophagic process of ferritinophagy, which provides free iron urgently needed as a cofactor for the synthesis of heme- and iron–sulfur proteins. Excessive activation of this pathway ends in ferroptosis, a special iron-dependent form of cell death, while hampered AMPK activation steadily reduces the iron pools, leading to hypoferremia with iron sequestration in the spleen and liver. Long-lasting iron depletion affects erythropoiesis and results in anemia of chronic disease, a common condition in patients with AD and its comorbidities. Instead of iron supplementation, drugs, diet, or phytochemicals that improve energy supply and cellular glucose uptake should be administered to counteract hypoferremia and anemia of chronic disease.

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Protection Against Drug-Induced Liver Injuries Through Nutraceuticals via Amelioration of Nrf-2 Signaling

Cited by 13 publications

References 130 publications

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Appraisal of the Antioxidant Activity, Polyphenolic Content, and Characterization of Selected Himalayan Herbs: Anti-Proliferative Potential in HepG2 Cells

Molecularly Engineered Room-Temperature Phosphorescence for Biomedical Application: From the Visible toward Second Near-Infrared Window

Why Is Iron Deficiency/Anemia Linked to Alzheimer’s Disease and Its Comorbidities, and How Is It Prevented?

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