Protection against feline infectious peritonitis by intranasal inoculation of a temperature-sensitive FIPV vaccine

Gerber, J D; Ingersoll, J D; Gast, Alison; Christianson, K K; Selzer, N.L.; Landon, R. M.; Pfeiffer, N. E.; Sharpee, R.L.; Beckenhauer, W H

doi:10.1016/0264-410x(90)90004-6

Cited by 57 publications

(49 citation statements)

References 9 publications

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“…The diffuse arteritis, the deposition of immunocomplexes on the vessel walls, the detection of C3 and C5, and the presence of an intravascular disseminated coagulation and a membranous glomerulonephritis has led many authors (HAYASHI et al, 1977(HAYASHI et al, ,1983PEDERSEN and BOYL,E, 1980;WEBS et al, 1980;WHSS and SCOTT, 1981;JACOBSE-GEES et al, 1982;FENNER, 1987;GERBER et al, 1990;PASTORET and BOURTONBOY, 1991;PEDERSEN, 1995) to ascribe the pathogenesis of fibrinous lesions of F W to a type I11 hypersensitivity reaction. This phenomenon would explain the pathogenesis of the vasculitis with effusions but perivisceral granulomas could be due to a type IV hypersensitivity reaction w i t h involvement of cellmediated immunity.…”

Section: Discussionmentioning

confidence: 99%

Type IV Hypersensitivity in the Pathogenesis of FIPV‐Induced Lesions

Paltrinieri

Parodi²,

Cammarata³

et al. 1998

Journal of Veterinary Medicine, Series B

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Summary In focal lesions of feline infectious peritonitis (FIP), the cells involved in the delayed‐type hypersensitivity were identified in formalin‐fixed paraffin‐embedded and frozen samples taken from 35 affected cats. The clinical diagnosis of FIP was confirmed by necropsy, histology and direct immunofluorescence against the coronaviruses on cryostatic sections. The immune cells were detected immunohistochemically by the Avidin‐Biotin‐Complex (ABC) method using either polyclonal antibodies against lymphoid antigens (CD3) or monoclonal antibodies against lymphoid (PAN‐T, CD4, CD8) and myeloid antigens (MAC387). Better identification of T cells and macrophages was found on formalin‐fixed paraffin‐embedded sections than on cryostatic ones, while T lymphocyte subpopulations could be differentiated only in cryostatic sections. Type IV hypersensitivity was detected in focal feline infectious peritonitis virus (FIPV)‐induced lesions from progressive activation of T lymphocytes, mainly CD4+, and the presence of granulocytes and macrophages. The FIPV‐induced lesions could be studied as examples of granulomas caused by unconventional antigens, such as viruses or immune complexes.

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Section: Discussionmentioning

confidence: 99%

Type IV Hypersensitivity in the Pathogenesis of FIPV‐Induced Lesions

Paltrinieri

Parodi²,

Cammarata³

et al. 1998

Journal of Veterinary Medicine, Series B

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“…For the cat there are FCV vaccines from several companies ( Table 2) but their efficacy against the newly emergent VS-FCV [35,112] remains unknown. The development of vaccines against FIP coronavirus (FIPV) has proved cumbersome and consequently there is only one (Pfizer's, not in Table 2) live intranasal temperature sensitive (TS) vaccine licensed in some countries [122,123]. However efficacy of this TS FIPV vaccine is a matter of debate [124,125].…”

Section: Company and Trade Namementioning

confidence: 99%

Review of companion animal viral diseases and immunoprophylaxis

Patel

Heldens²

2009

Vaccine

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In this article we review important established, newly emergent and potential viral diseases of cats, dogs and rabbits. Topics covered include virus epidemiology, disease pathogenesis, existing and prospective immunoprophylaxis against the viruses. For some feline viruses, notably the immunodeficiency virus, leukaemia virus and peritonitis virus, available vaccines are poorly efficacious but there are good prospects for this. A further challenge for the industry is likely to be due to viruses jumping species and the emergence of more virulent variants of established viruses resulting from mutations as has been the case for the canine parvovirus, coronaviruses and feline calicivirus.

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“…Currently, a temperature-sensitive strain of FIPV is marketed as a vaccine (Christianson et al, 1989). Although its ability to protect cats against FIPV was demonstrated (Gerber et al, 1990 ;Gerber, 1995), the efficacy of this vaccine is a matter of debate (Fehr et al, 1997 ;McArdle et al, 1995 ;Scott et al, 1995).…”

Section: ) These Mutants Are Conveniently Designated Fip Virusesmentioning

confidence: 99%

Feline Infectious Peritonitis Virus

Horzinek¹,

Osterhaus²,

Ellens³

1977

Zentralblatt für Veterinärmedizin Reihe B

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Cell-mediated immunity is thought to play a decisive role in protecting cats against feline infectious peritonitis (FIP), a progressive and lethal coronavirus disease. In view of the potential of DNA vaccines to induce cell-mediated responses, their efficacy to induce protective immunity in cats was evaluated. The membrane (M) and nucleocapsid (N) proteins were chosen as antigens, because antibodies to the spike (S) protein of FIP virus (FIPV) are known to precipitate pathogenesis. However, vaccination by repeated injections of plasmids encoding these proteins did not protect kittens against challenge infection with FIPV. Also, a prime-boost protocol failed to afford protection, with priming using plasmid DNA and boosting using recombinant vaccinia viruses expressing the same coronavirus proteins. Because of the role of IL-12 in initiating cell-mediated immunity, the effects of co-delivery of plasmids encoding the feline cytokine were studied. Again, IL-12 did not meet expectations -on the contrary, it enhanced susceptibility to FIPV challenge. This study shows that DNA vaccination failed to protect cats against FIP and that IL-12 may yield adverse effects when used as a cytokine adjuvant.

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Protection against feline infectious peritonitis by intranasal inoculation of a temperature-sensitive FIPV vaccine

Cited by 57 publications

References 9 publications

Type IV Hypersensitivity in the Pathogenesis of FIPV‐Induced Lesions

Type IV Hypersensitivity in the Pathogenesis of FIPV‐Induced Lesions

Review of companion animal viral diseases and immunoprophylaxis

Feline Infectious Peritonitis Virus

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