Protection against influenza a virus infection in mice by oral immunization with a polyvalent bacterial lysate

Daal, G. J. van; Beusenberg, F. D.; So, K. L.; Fievez, R. B.; Sprenger, M. J. W.; Mouton, Johan W.; Veen, Annemarie van ‘t; Lachmann, Burkhard

doi:10.1016/0192-0561(91)90034-5

Cited by 12 publications

(10 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This concept has been explored as an alternative to the traditional influenza virus vaccine [97,98]. In mice, oral immunization with bacterial lysate composed of antigens derived from S. aureus, Streptococcus pyogenes, S. pneumoniae, Streptococcus mitis, Klebsiella pneumoniae, Moraxella catarrhalis and Haemophilus influenzae reduces mortality due to influenza virus infection [97].…”

Section: Inhibitory Effects Of S Pneumoniae On Viral Replicationmentioning

confidence: 99%

Interactions Between Streptococcus Pneumoniae and Influenza Virus: A Mutually Beneficial Relationship?

et al. 2012

View full text Add to dashboard Cite

Historically, most research on infectious diseases has focused on infections with single pathogens. However, infections with pathogens often occur in the context of pre-existing viral and bacterial infections. Clinically, this is of particular relevance for coinfections with Streptococcus pneumoniae and influenza virus, which together are an important cause of global morbidity and mortality. In recent years new evidence has emerged regarding the underlying mechanisms of influenza virus-induced susceptibility to secondary pneumococcal infections, in particular regarding the sustained suppression of innate recognition of S. pneumoniae. Conversely, it is also increasingly being recognized that there is not a unidirectional effect of the virus on S. pneumoniae, but that asymptomatic pneumococcal carriage may also affect subsequent influenza virus infection and the clinical outcome. Here, we will review both aspects of pneumococcal influenza virus infection, with a particular focus on the age-related differences in pneumococcal colonization rates and invasive pneumococcal disease.

show abstract

Section: Inhibitory Effects Of S Pneumoniae On Viral Replicationmentioning

confidence: 99%

Interactions Between Streptococcus Pneumoniae and Influenza Virus: A Mutually Beneficial Relationship?

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Wc recently demonstrated that oral immunization with a bacterial lysate significantly reduces mortality in mice in fected with Streptococcus pneumoniae [1,2] or influenza A virus [2,3]. One of the protective mechanisms of oral im munization, apart from induction of specific immunity [for review see 4], might be limitation of the alveolar inflam matory reaction after infection and thereby reduction of pulmonary damage.…”

Section: Introductionmentioning

confidence: 99%

Oral Immunization with Polyvalent Bacterial Lysate and Infection with <i>Streptococcus</i> <i>pneumoniae</i>: Influence on Interferon-Gamma and PMN Elastase Concentrations in Murine Bronchoalveolar Lavage Fluid

A²,

Kl³

et al. 1992

Int Arch Allergy Immunol

View full text Add to dashboard Cite

We recently demonstrated that oral immunization with a polyvalent bacterial lysate (Paspat oral®) significantly reduces mortality rates in mice, infected with Streptococcus pneumoniae or influenza A virus. In this study it is demonstrated that oral immunization with the same bacterial lysate reduces the intrapulmonary inflammatory reaction to infection with S. pneumoniae, assessed by measurement of PMN elastase in bronchoalveolar lavage fluid. Furthermore, it is demonstrated that oral immunization with Paspat oral® increases intrapulmonary IFN-gamma concentrations.

show abstract

“…Taken together, our data indicate that the administration of LW50020 via the oral route results in a protective immunological reaction at least against the Klebsiella component of the preparation. Nonspecific effects of the lysate have also been described [18,21], but obviously these do not play a major role in the enhanced resistance against Klebsiella. It would be interesting to know whether the Klebsiella component is also involved in the enhanced, nonspecific resistance induced by heptavalent vaccine e.g.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of orally administered, Klebsiella-containing bacterial lysates in mice

Kuenen

Dijke

Hol

et al. 1994

FEMS Immunology &Amp; Medical Microbiology

View full text Add to dashboard Cite

The efficacy, as oral vaccines, of hepta- and mono-valent, Klebsiella-containing bacterial lysates and a number of control preparations was tested in mice. The preparations were administered during two periods of four days each, interrupted by an interval of 3 days. Fourteen days after the first dose, the animals were challenged either intraperitoneally (i.p.; peritonitis/sepsis model) or intranasally (i.n.; pneumonia model). Animals treated with low doses of Klebsiella lysate, in the form of either a 7-valent lysate or a Klebsiella monolysate, showed enhanced survival in both the peritonitis/sepsis and the pneumonia models. Hexa- and tetra-valent preparations without Klebsiella were not protective in the models tested. Furthermore, it was found that the protection is accompanied by priming for Klebsiella-specific IgG responsiveness (probably at the T cell level) and by significant IgA anti-Klebsiella serum antibody levels in about one third of the animals. The oral efficacy of Klebsiella-containing lysates suggests the presence of an adjacent component that directs Klebsiella antigen(s) to follow a selective intestinal pathway which renders them immunogenic. The identity of this component is under investigation.

show abstract

Protection against influenza a virus infection in mice by oral immunization with a polyvalent bacterial lysate

Cited by 12 publications

References 39 publications

Interactions Between Streptococcus Pneumoniae and Influenza Virus: A Mutually Beneficial Relationship?

Interactions Between Streptococcus Pneumoniae and Influenza Virus: A Mutually Beneficial Relationship?

Oral Immunization with Polyvalent Bacterial Lysate and Infection with <i>Streptococcus</i> <i>pneumoniae</i>: Influence on Interferon-Gamma and PMN Elastase Concentrations in Murine Bronchoalveolar Lavage Fluid

Protective effects of orally administered, Klebsiella-containing bacterial lysates in mice

Contact Info

Product

Resources

About