Protection Against Influenza After Annually Repeated Vaccination

Beyer, Walter; Bruijn, Iris A. de; Palache, Abraham; Westendorp, R.G.J.; Osterhaus, Albert D. M. E.

doi:10.1001/archinte.159.2.182

Cited by 165 publications

(106 citation statements)

References 39 publications

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“…We could not establish a statistically significant difference in effectiveness as compared with those few subjects who received the vaccine for the first time. This is in agreement with the findings of Beyer et al who did not observe modified vaccine effectiveness resulting from prior immunization in a large metaanalysis [33].…”

Section: Discussionsupporting

confidence: 93%

Clinical effectiveness of conventional influenza vaccination in asthmatic children

et al. 2002

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SUMMARYInfluenza immunization rates among young asthmatics remain unsatisfactory due to persistent concern about the impact of influenza and the benefits of the vaccine. We assessed the effectiveness of the conventional inactivated trivalent sub-unit influenza vaccine in reducing acute respiratory disease in asthmatic children. We conducted a two-season retrospective cohort study covering the 1995-6 and 1996-7 influenza outbreaks in 22 computerized primary care practices in the Netherlands. In total, 349 patients aged between 0 and 12 years meeting clinical asthma-criteria were included ; 14 children were lost to follow-up in the second season. The occurrence of physician-diagnosed acute respiratory disease episodes including influenzalike illness, pneumonia, bronchitis, bronchiolitis, asthma exacerbation and acute otitis media in vaccinated and unvaccinated children were compared after adjustments for age, prior health care and medication use. The occurrence of acute respiratory disease in unvaccinated children was 28 % and 24 % in the 1995-6 and 1996-7 season, respectively, and was highest in children under 6 years of age (43 %). The overall pooled clinical vaccine effectiveness was 27 % (95 % confidence interval k7 to 51%, P l 0n11) after adjustments. A statistically higher vaccine protectiveness of 55 % (95 % CI 20-75 %, P l 0n01) was observed among asthmatics under 6 years of age compared with k5 % in older children (95 % CI k81 to 39 %).

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Section: Discussionsupporting

confidence: 93%

Clinical effectiveness of conventional influenza vaccination in asthmatic children

et al. 2002

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“…Annually repeated vaccinations do not lead to a decreasing immune response or protection [294]. Although much less studied, repeated vaccinations annually, or even more frequent, do not lead to more side-effects than after primary vaccination [294,295].…”

Section: Is Vaccination Cost-effective?mentioning

confidence: 99%

Guidelines for the management of adult lower respiratory tract infections

Woodhead¹

2005

Eur Respir J

685

555

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“…In contrast, the proportion of baseline seropositive subjects was inversely correlated with seroconversion. A previous meta‐analysis of annual vaccination studies found no difference in seroprotection rates between unvaccinated and previously vaccinated individuals 90 . However, individuals with high baseline titers may easily achieve the seroprotection threshold, but may not be able to generate a fourfold increase.…”

Section: Discussionmentioning

confidence: 90%

Quantitative review of antibody response to inactivated seasonal influenza vaccines

Seidman

Richard

Viboud

et al. 2011

Influenza Resp Viruses

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Please cite this paper as: Seidman et al. (2012) Quantitative review of antibody response to inactivated seasonal influenza vaccines. Influenza and Other Respiratory Viruses 6(1), 52–62. Background Seasonal influenza epidemics are associated with significant morbidity and mortality each year, particularly amongst young children and the elderly. Seasonal influenza vaccines have been available for decades, yet influenza remains a major public health threat in the US, sparking interest in studies evaluating the effectiveness of vaccination. Objectives We sought to identify determinants of serological responses to inactivated seasonal influenza vaccines including number of doses, adjuvant, and subject characteristics. Methods We reviewed 60 articles published between 1987 and 2006. We used weighted multiple logistic regression and random‐effects models to evaluate how seroconversion and seroprotection rates varied with host and vaccine factors. Results Both children and seniors tended to have poorer immune responses compared to adults whereas use of adjuvant and a second vaccine dose tended to improve immune response. Pre‐vaccination serological status had a large impact on the immune response to vaccination. We found substantial heterogeneity among studies, even with similar population settings and vaccination regimen. Conclusions Future studies should stratify their results by pre‐vaccination serological status in an effort to produce more precise summary estimates of vaccine response.

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Protection Against Influenza After Annually Repeated Vaccination

Cited by 165 publications

References 39 publications

Clinical effectiveness of conventional influenza vaccination in asthmatic children

Clinical effectiveness of conventional influenza vaccination in asthmatic children

Guidelines for the management of adult lower respiratory tract infections

Quantitative review of antibody response to inactivated seasonal influenza vaccines

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