Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

Seder, Robert A.; Chang, Lee-Jah; Enama, Mary E.; Zephir, Kathryn L; Sarwar, Uzma; Gordon, Ingelise J.; Holman, La Sonji A.; James, Eric R.; Billingsley, Peter F.; Gunasekera, Anusha; Richman, Adam; Chakravarty, Sumana; Manoj, Anita; Velmurugan, Soundarapandian; Li, Ming Lin; Ruben, Adam J.; Tao, Li; Eappen, Abraham G.; Stafford, R. E.; Plummer, Sarah H.; Hendel, Cynthia S.; Novik, Laura; Costner, Pamela; Mendoza, Floreliz; Saunders, Jamie; Nason, Martha; Richardson, Jason H.; Murphy, Jittawadee; Davidson, Silas A.; Richie, Thomas L.; Sedegah, Martha; Sutamihardja, Awalludin; Fahle, Gary A.; Lyke, Kirsten E.; Laurens, Matthew B.; Roederer, Mario; Tewari, Kavita; Epstein, Judith E.; Sim, B. Kim Lee; Ledgerwood, Julie E.; Graham, Barney S.; Hoffman, Stephen L.

doi:10.1126/science.1241800

Cited by 714 publications

(835 citation statements)

References 47 publications

Supporting

Mentioning

787

Contrasting

Unclassified

Order By: Relevance

“…Experimental sporozoite vaccines have either been delivered as irradiated parasites that can infect host cells but fail to differentiate and cause disease, or as live parasites 21, 77, 78. In this instance, anti‐malarial drugs must be given to prevent active disease.…”

Section: Human Vaccines: Recent Progress and Continuing Challengesmentioning

confidence: 99%

The roles of resident, central and effector memory CD4 T‐cells in protective immunity following infection or vaccination

2018

View full text Add to dashboard Cite

SummaryImmunological memory provides rapid protection to pathogens previously encountered through infection or vaccination. CD4 T‐cells play a central role in all adaptive immune responses. Vaccines must, therefore, activate CD4 T‐cells if they are to generate protective immunity. For many diseases, we do not have effective vaccines. These include human immunodeficiency virus (HIV), tuberculosis and malaria, which are responsible for many millions of deaths each year across the globe. CD4 T‐cells play many different roles during the immune response coordinating the actions of many other cells. In order to harness the diverse protective effects of memory CD4 T‐cells, we need to understand how memory CD4 T‐cells are generated and how they protect the host. Here we review recent findings on the location of different subsets of memory CD4 T‐cells that are found in peripheral tissues (tissue resident memory T‐cells) and in the circulation (central and effector memory T‐cells). We discuss the generation of these cells, and the evidence that demonstrates how they provide immune protection in animal and human challenge models.

show abstract

Section: Human Vaccines: Recent Progress and Continuing Challengesmentioning

confidence: 99%

The roles of resident, central and effector memory CD4 T‐cells in protective immunity following infection or vaccination

2018

View full text Add to dashboard Cite

show abstract

“…Plasmodium falciparum (Pf) sporozoites (SPZ) are the only immunogens ever shown to induce >90%, sterile protective immunity against malaria (2)(3)(4). Until recently, this had only been accomplished by immunization by mosquito bite.…”

Section: I N I C a L M E D I C I N Ementioning

confidence: 99%

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine

et al. 2017

Self Cite

View full text Add to dashboard Cite

“…These vaccines were usually poorly immunogenic and often caused significant side effects (table 1), so that whole-cell vaccines have largely given way to subunit vaccines. However, there has recently been a renewed interest in use of wholecell vaccines, which have the advantage of presenting multiple antigens, and whole-cell, attenuated pneumococcal [11] and malaria [12,13] rstb.royalsocietypublishing.org Phil. Trans.…”

Section: (B) the Next Generation Of Vaccinesmentioning

confidence: 99%

The contribution of vaccination to global health: past, present and future

Greenwood

2014

Phil. Trans. R. Soc. B

775

516

View full text Add to dashboard Cite

Vaccination has made an enormous contribution to global health. Two major infections, smallpox and rinderpest, have been eradicated. Global coverage of vaccination against many important infectious diseases of childhood has been enhanced dramatically since the creation of WHO's Expanded Programme of Immunization in 1974 and of the Global Alliance for Vaccination and Immunization in 2000. Polio has almost been eradicated and success in controlling measles makes this infection another potential target for eradication. Despite these successes, approximately 6.6 million children still die each year and about a half of these deaths are caused by infections, including pneumonia and diarrhoea, which could be prevented by vaccination. Enhanced deployment of recently developed pneumococcal conjugate and rotavirus vaccines should, therefore, result in a further decline in childhood mortality. Development of vaccines against more complex infections, such as malaria, tuberculosis and HIV, has been challenging and achievements so far have been modest. Final success against these infections may require combination vaccinations, each component stimulating a different arm of the immune system. In the longer term, vaccines are likely to be used to prevent or modulate the course of some non-infectious diseases. Progress has already been made with therapeutic cancer vaccines and future potential targets include addiction, diabetes, hypertension and Alzheimer's disease.

show abstract

Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine

Cited by 714 publications

References 47 publications

The roles of resident, central and effector memory CD4 T‐cells in protective immunity following infection or vaccination

The roles of resident, central and effector memory CD4 T‐cells in protective immunity following infection or vaccination

Protection against Plasmodium falciparum malaria by PfSPZ Vaccine

The contribution of vaccination to global health: past, present and future

Contact Info

Product

Resources

About