Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats

Jiang, Zhitao; Xu, Bo; Yang, Mowen; Li, Zhaozhu; Zhang, Yubo; Jiang, Dapeng

doi:10.1111/bcpt.12016

Cited by 27 publications

(23 citation statements)

References 23 publications

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“…Inspiringly, although the radioprotective effects of H2 have been shown to be less than WR-2721, the exceeded protective effect of WR-2721 seems not to be prominent. In accordance with these results, in later papers by Chuai Y et al and by Jiang Z et al, they also demonstrated the radioprotective effects of hydrogen on testis 13, 56 by protecting seminiferous epithelium, preserving testis weight, testis dimensions, sperm count, sperm motility from IR. However, in the paper by Jiang Z et al, it was found that the radioprotective effect of hydrogen on testis is similar to WR-2721 at one time point (after a 4-day initiation of irradiation) which is better than the results by our group.…”

Section: Testissupporting

confidence: 66%

Hydrogen as a New Class of Radioprotective Agent

Qian¹,

Shen²,

Chuai³

et al. 2013

Int. J. Biol. Sci.

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It is well known that most of the ionizing radiation-induced damage is caused by hydroxyl radicals (·OH) follows radiolysis of H2O. Molecular hydrogen (H2) has antioxidant activities by selectively reducing ·OH and peroxynitrite(ONOO-). We firstly hypothesized and demonstrated the radioprotective effect of H2 in vitro and in vivo, which was also repeated on different experimental animal models by different departments. A randomized, placebo-controlled study showed that consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects. These encouraging results suggested that H2 represents a potentially novel preventative strategy for radiation-induced oxidative injuries. H2 is explosive. Therefore, administration of hydrogen-rich solution (physiological saline/pure water/other solutions saturated with H2) may be more practical in daily life and more suitable for daily consumption. This review focuses on major scientific and clinical advances of hydrogen-rich solution/H2 as a new class of radioprotective agent.

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Section: Testissupporting

confidence: 66%

Hydrogen as a New Class of Radioprotective Agent

Qian¹,

Shen²,

Chuai³

et al. 2013

Int. J. Biol. Sci.

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“…It has been documented that ionising radiation induces metabolic oxidative stress and apoptosis in the dividing cells (Agrawal & Kale, ; Arora et al, ). Previous studies showed TUNEL‐positive cells or bodies in irradiated animals (Jiang et al., ; Kim et al., ). There are reports of decrease in apoptosis induced in X‐ray‐exposed animals which were treated with various plant extracts like Psidium guajava , Panax ginseng , Punica Granatum (Kim et al, ; Kumar et al., ; Toklu et al., ).…”

Section: Discussionmentioning

confidence: 86%

“…Various forms of radiation exposure can cause sex hormonal disorders. Testosterone levels decreased significantly after X‐ray irradiation in mice (Abdel‐Magied & Ahmed, ; Jiang et al., ; Kim et al, ). Osman () observed testicular damage after gamma ray irradiation in rats.…”

Section: Discussionmentioning

confidence: 99%

Protective role ofAloe veraagainst X-ray induced testicular dysfunction

et al. 2016

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The present investigation was carried out to evaluate the possible radioprotective potential of an Aloe vera extract against whole-body X-ray irradiation-induced testicular alterations in mice. Male balb/c mice were divided into four groups: control, A. vera, X-ray and A. vera pre-treated + X-ray irradiated. Histopathological examination revealed significant structural alterations in testes after X-ray exposure, which was also associated with the presence of apoptotic cells as assessed by TUNEL assay. X-ray irradiation resulted in elevation in the levels of reactive oxygen species, lipid peroxidation, a reduction in glutathione concentration and enhanced activities of antioxidant enzymes such as glutathione reductase, glutathione peroxidase, catalase, superoxide dismutase and glutathione-S-transferase. Sperm count/motility and testosterone levels were significantly decreased in the irradiated group. Irradiated animals pre-treated with A. vera extract revealed an improvement in antioxidant status, inhibition of lipid peroxides, apoptotic cell formation and enhanced testicular parameters when compared to the X-ray-exposed group. These findings suggest that A. vera extract could ameliorate X-ray-induced damage due to its free radical scavenging properties and its potential to boost cellular antioxidant defence machinery.

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“…This represented the first in vivo evidence to suggest H 2 radioprotection through ·OH neutralization in irradiated tissue. HS was also shown to play a radio-protective role in a gamma ray-induced rat testicular damage model [ 190 ]. Thus, H 2 therapy may effectively preserve fertility in males exposed to irradiation.…”

Section: Preventive and Therapeutic Applications Of Hmentioning

confidence: 99%

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

et al. 2017

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Since the 2007 discovery that molecular hydrogen (H2) has selective antioxidant properties, multiple studies have shown that H2 has beneficial effects in diverse animal models and human disease. This review discusses H2 biological effects and potential mechanisms of action in various diseases, including metabolic syndrome, organ injury, and cancer; describes effective H2 delivery approaches; and summarizes recent progress toward H2 applications in human medicine. We also discuss remaining questions in H2 therapy, and conclude with an appeal for a greater role for H2 in the prevention and treatment of human ailments that are currently major global health burdens. This review makes a case for supporting hydrogen medicine in human disease prevention and therapy.

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Protection by Hydrogen Against Gamma Ray‐Induced Testicular Damage in Rats

Cited by 27 publications

References 23 publications

Hydrogen as a New Class of Radioprotective Agent

Hydrogen as a New Class of Radioprotective Agent

Protective role ofAloe veraagainst X-ray induced testicular dysfunction

Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

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