Protection efficacy of the &lt;i&gt;Brucella abortus&lt;/i&gt; ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models

Kwon, Ae Jeong; Moon, Jin Woo; Kim, Won Kyong; Kim, Suk; Hur, Jin

doi:10.1292/jvms.16-0036

Cited by 4 publications

(1 citation statement)

References 51 publications

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“…In the case of Brucella , it has been reported that Brucella S2 ghosts effectively elicit a pathogen-specific antibody response, enhancing IgG antibody and T cell responses in mice compared to inactivated bacteria ( 170 ). Kwon et al used a fragment of PMPA-36 (porcine myeloid antimicrobial peptide 36), named GI24, for B. abortus lysis and produced B. abortus ghosts, termed as B. abortus lysed cells ( 171 ). Due to the lack of genetic materials in BG vaccines, the horizontal transfer of antibiotic resistance genes or pathogenic islands to the resident gut flora does not occur.…”

Section: Other Vaccinesmentioning

confidence: 99%

Evaluation of Brucellosis Vaccines: A Comprehensive Review

Heidary

Dashtbin

Ghanavati³

et al. 2022

Front. Vet. Sci.

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Brucellosis is a bacterial zoonosis caused by Brucella spp. which can lead to heavy economic losses and severe human diseases. Thus, controlling brucellosis is very important. Due to humans easily gaining brucellosis from animals, animal brucellosis control programs can help the eradication of human brucellosis. There are two popular vaccines against animal brucellosis. Live attenuated Brucella abortus strain 19 (S19 vaccine) is the first effective and most extensively used vaccine for the prevention of brucellosis in cattle. Live attenuated Brucella melitensis strain Rev.1 (Rev.1 vaccine) is the most effective vaccine against caprine and ovine brucellosis. Although these two vaccines provide good immunity for animals against brucellosis, the expense of persistent serological responses is one of the main problems of both vaccines. The advantages and limitations of Brucella vaccines, especially new vaccine candidates, have been less studied. In addition, there is an urgent need for new strategies to control and eradicate this disease. Therefore, this narrative review aims to present an updated overview of the available different types of brucellosis vaccines.

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Section: Other Vaccinesmentioning

confidence: 99%

Evaluation of Brucellosis Vaccines: A Comprehensive Review

Heidary

Dashtbin

Ghanavati³

et al. 2022

Front. Vet. Sci.

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The development of ghost vaccines trials

Batah

Ahmad

2020

Expert Review of Vaccines

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Brucella abortus lysed cells using GI24 induce robust immune response and provide effective protection in Beagles

Kim

Moon

Cho

et al. 2017

Pathogens and Disease

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The aim of the present study is to estimate the protective efficacy of Brucella abortus lysed cells by GI24 against brucellosis in Beagles. Group A was subcutaneously (sc) immunized with sterile phosphate-buffered saline, and group B was sc immunized with approximately 3 × 109 of the lysed cells. Brucella-LPS-specific serum IgG titers and IL-4, TNF-α and IFN-γ concentrations were investigated by enzyme linked immunosorbent assay. All dogs were intraconjunctivally challenged with B. abortus strain 544 at 6 weeks post-prime immunization. The serum IgG titers were considerably higher in group B than in group A. The levels of IL-4, TNF-α and IFN-γ in group B than in group A were significantly higher. Following challenge, no challenge strain was observed from all tissues of three dogs of group B. However, challenge strain was detected from spleen, uterus (except one Beagle) and inguinal and retropharyngeal lymph nodes of all group A Beagles. The results of this study demonstrated that sc immunization with the lysed cells induced robust antibody and cell-mediated immune responses in Beagles. The lysed cells also conferred protection against infection with B. abortus. These results suggest that sc immunization with B. abortus lysed cells by GI24 is a good vaccine candidate against brucellosis in dogs.

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Protection efficacy of the <i>Brucella abortus</i> ghost vaccine candidate lysed by the N-terminal 24-amino acid fragment (GI24) of the 36-amino acid peptide PMAP-36 (porcine myeloid antimicrobial peptide 36) in murine models

Cited by 4 publications

References 51 publications

Evaluation of Brucellosis Vaccines: A Comprehensive Review

Evaluation of Brucellosis Vaccines: A Comprehensive Review

The development of ghost vaccines trials

Brucella abortus lysed cells using GI24 induce robust immune response and provide effective protection in Beagles

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