Protection from vascular risk in diabetic hypertension

The present study investigated the anti-diabetic effects of new herbal formula (NHF) consist of Polygonati Rhizoma, Rehmanniae Radix, Salviae miltiorrhizae Radix, Puerariae Radix, Schizandrae Fructus, Glycyrrhizae Radix in neonatal streptozotocin (nSTZ)-induced non-insulin-dependent diabetes mellitus (NIDDM) rats. Changes of food and water intakes, body weight, blood glucose, plasma insulin and immunohistochemical evaluation of insulin on pancreas, and mRNA expression of glucose transporter subtype-4 (GLUT-4) in skeletal muscle and hepatic phosphoenolpyruvate carboxykinase (PEPCK) by administration of NHF (300 mg/kg) were investigated. The nSTZ diabetic rats showed hyperglycemia, increases in food and water intake, loss of body weight gain and decrease of the number of insulin-positive cells and the size of b b-cells in pancreas and mRNA of GLUT-4 in soleus muscle and increase of hepatic PEPCK mRNA expression. Administration of NHF significantly decreased the blood glucose level, food and water intake and considerably increased the body weight of nSTZ diabetic rats. Also, NHF treatment significantly increased plasma insulin level and the number and size of insulinimmunoreactive cells in the pancreas of nSTZ diabetic rats. In addition, NHF treatment resulted in increased expression of the GLUT-4 mRNA in soleus muscle and in reduced expression of PEPCK mRNA in liver. These results provide possible mechanisms for the anti-diabetic effects of NHF, via a decrease of blood glucose level, an increase of insulin sensitivity, an increase of GLUT-4 gene expression and an attenuation of hepatic PEPCK gene expression. In conclusion, NHF may be useful for improving hyperglycemia and reducing the risk of diabetic complications.

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“…15) Worldwide, the number of patients is rapidly growing with an increase in obesity and aging in the general population.…”

Section: Fig 6 Histological Observations and Immunohistochemical Stmentioning

confidence: 99%

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

Kim

Lee

Kwon

et al. 2009

Biological & Pharmaceutical Bulletin

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“…For this purpose a series of cinnamoyl and hydroxycinnamoyl amides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) were synthesized in solution phase by EDC/HOBt-mediated couplings as in previously described procedure [33]. Moreover, for the synthesis of C-terminal peptide amides (compounds 15, 16) the standard Fmoc-SPPS was carried out on Rink amide resin.…”

Section: Resultsmentioning

confidence: 99%

“…amides (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) were obtained in moderate to excellent yields by solution phase peptide synthesis, according to the previously described procedure [33]. The chemical structures of all known compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14) have been assigned on the basis of their spectral data and compared with published data [33,34].…”

Section: Solution Phase Peptide Synthesis N-hydroxycinnamoylmentioning

confidence: 99%

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Structure-Activity Relationships ofN-Cinnamoyl and Hydroxycinnamoyl Amides onα-Glucosidase Inhibition

Chochkova

Petrova

Stoykova

et al. 2017

Journal of Chemistry

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Currently, there is an increasing interest towards -glucosidase inhibition of various diseases including diabetes mellitus type 2, cancer, HIV, and B-and C-type viral hepatitis. Cinnamic acid derivatives have been shown to be potentially valuable as a new group of -glucosidase inhibitors. Therefore, herein, the -glucosidase inhibitory activity of trans-N-cinnamoyl and hydroxycinnamoyl amides was studied in vitro. Results revealed that the tested hydroxycinnamoyl amides (1-16) inhibited a-glucosidase with IC 50 s ranging between 0.76 and 355.1 g/ml. Compounds 1, 2, 5, 6, 9, 14, and 15 showed significant inhibition of yeast -glucosidase, being even more potent ones than the used positive inhibitor acarbose (IC 50 = 2.50 ± 0.21 g/ml).

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“…1 This disease often associated with high blood glucose (hyperglycemia), increase levels of TC, TG, LDL-C (hyperlipidemia), but decrease levels of HDL-C. The hyperglycemia can increase the incidence of many complications in diabetic patients [2][3][4] while hyperlipidemia contributes the development of coronary heart diseases and atherosclerosis, which are the most common cause of mortality and morbidity. 5 Plukao (Houttuynia cordata Thunb.…”

Section: Introductionmentioning

confidence: 99%

Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats

Poolsil¹,

Promprom²,

Talubmook³

2017

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Aim: Various properties of Houttuynia cordata Thumb. has been reported. However, few studies on its pharmacological effects have been documented. To elucidate whether there are more pharmacological effects of this plant, this study was therefore, carried out to determine the anti-hyperglycemic and anti-hyperlipidemic effects of 80% ethanol extract of H. cordata (HCE). Their antioxidant activity and acute toxicity were also conducted. Methods: HCE at a dose of 250 mg/kg was oral given to Streptozotocin-induced diabetic rats daily for 8 weeks. DPPH assay and HCE at the doses of 1,000, 2,000 and 3,000 mg/kg were employed in antioxidant and acute toxicity studies. Results: HCE lowered FBG in the diabetic, but not in the normal treated rats. HCE did not affect the body weight of all rats, but recovered TP, Alb, Glob, BUN, CREA, UA, TB, AST, ALT, ALP, and reduced the elevated CHO, TG and LDL in the diabetic rats. HCE possessed relatively low antioxidant activity with IC 50 of 115.98± 0.82 µg/mL compared to Vitamin C (42.54+1.37 µg/ml), but did not produce any symptoms of acute toxicity. Conclusions: The extract of H. cordata may have beneficial properties and is a new agent for diabetic treatment and improve renal and hepatic functions.

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Protection from vascular risk in diabetic hypertension

Cited by 23 publications

References 39 publications

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

Anti-diabetic Effects of New Herbal Formula in Neonatally Streptozotocin-Induced Diabetic Rats

Structure-Activity Relationships ofN-Cinnamoyl and Hydroxycinnamoyl Amides onα-Glucosidase Inhibition

Anti-hyperglycemic and Anti-hyperlipidemic Effects of Extract from Houttuynia cordata Thumb. in Streptozotocin-Induced Diabetic Rats

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