Protection in alpacas against Corynebacterium pseudotuberculosis using different bacterial components

Braga, W.

doi:10.1016/j.vetmic.2006.08.019

Cited by 15 publications

(20 citation statements)

References 13 publications

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“…The presence of CLA had been recognized for over 100 years (Fontaine and Baird 2008) and has been reported in infected sheep in Australia, New Zealand, South Africa, Middle east, North and South America, England, and in most parts of Northern and Southern Europe (Ghadimi 1993; Dercksen et al 2000; Fontaine and Baird 2008; Fontaine et al 2006; O’Reilly et al 2008; Radostits et al 2007; Smith 2002). The disease has been reported in other animals such as horse, lama, alpaca, buffalo, deer, and camels (Ghadimi 1993; Braga 2007; Fontaine and Baird 2008; Smith 2002). Occasionally, abortions have been reported due to C. pseudotuberculosis in sheep (Fontaine and Baird 2008).…”

Section: Introductionmentioning

confidence: 90%

Frequency of caseous lymphadenitis (CLA) in sheep slaughtered in an abattoir in Tabriz: comparison of bacterial culture and pathological study

et al. 2011

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From January to February 2008, 468 sheep carcasses (335 male and 133 female) in a Khosroshahr (suburb of Tabriz, East Azerbaijan province, Iran) abattoir were randomly selected for inspection. The aim of the study was to estimate the frequency of caseous lymphadenitis (CLA) in sheep and to compare the results of bacterial cultures and histopathology of suspected cases. The mean age of the population was 2.5 years. One hundred ninety-seven cases containing 153 (77.7%) males and 44 (22.3%) females had prominent enlargement of one of the lymph nodes (i.e., prescapular, prefemoral, inguinal, supramammary, or midiastinal); these were removed with the surrounding tissue for further evaluation. For confirmed diagnosis of CLA, samples were sent for microbiology and pathology analysis. Standard bacteriological culture methods for isolation of Corynebacterium pseudotuberculosis and tissue preparations for histopathological sections were performed. To evaluate the effect of age on the frequency of CLA, animals were categorized in four groups: under 1, 1–2, 2–3, and over 3 years of age. Based on the results, in 59 (12.60%) carcasses C. pseudotuberculosis was isolated, and in 94 (20.08%) of the cases histopathological studies revealed pathognomonic signs (lamellated exudates or onion ring) of CLA. The frequency of CLA based on bacteriological culture was 12.60% and on histopathological study 20.08%. In 37 (18.8%) of the carcasses, both bacteriological and histopathological studies confirmed CLA. The frequency of CLA following microscopic examination (20.08%) presented a more precise diagnosis compared to bacteriological culture (12.60%) and macroscopic evaluation of the lymph nodes (P < 0.05). Furthermore, there was a positive correlation rate between the bacteriological culture and histopathological study (r = 0.196, P = 0.006). The prescapular lymph node had the highest infection rate with 54 (1.70 ± 0.97) and supramammary lymph node had the lowest with two (0.07 ± 0.41) (P < 0.05). There was an increase in CLA detection with increasing age (P < 0.05), the mean age of animals with a positive CLA test were 2.92 years and in the oldest age group 31 (47%) cases had the highest infection.

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Section: Introductionmentioning

confidence: 90%

Frequency of caseous lymphadenitis (CLA) in sheep slaughtered in an abattoir in Tabriz: comparison of bacterial culture and pathological study

et al. 2011

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“…Toxoid vaccines, based on treated exotoxins of C. pseudotuberculosis, have also been widely described (Brown et al 1986;Holstad et al 1989;Eggleton et al 1991b;Eggleton et al 1991a;Ellis et al 1991;Braga 2007;Moura-costa et al 2008). This strategy is based on using treated exotoxins with formaldehyde or heat producing toxoids that are being administered in low doses of infection in a first immunization, to provide protection to the vaccinated animal in a subsequent infection (Braga et al 2007).…”

Section: Toxoidmentioning

confidence: 99%

Vaccines for caseous lymphadenitis: up-to-date and forward-looking strategies

Pinho

Silva

Bezerra

et al. 2021

Appl Microbiol Biotechnol

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Caseous lymphadenitis (CLA) is an infectious chronic disease responsible for economic losses in sheep and goat breeding worldwide. CLA has no effective treatment, evidencing the vaccination schedule as the best control strategy. Although some commercial vaccines have been available, none of them provides total protection, which is sometimes insufficient and does not reach the same efficiency when compared in sheep and goats. They also have questionable safety levels and side effects. In light of this, several experimental vaccines are in development in order to improve safety, reproducibility, and protective immune response against the etiologic agent of CLA, Corynebacterium pseudotuberculosis . In this review, we discussed aspects as antigen, adjuvant, routes of administration, protection level, and animal models used in CLA vaccine development, as well the challenges and future perspectives. Key points Caseous lymphadenitis ( CLA ) does not have an appropriate commercial vaccine . Different experimental vaccines are in development aiming to protect against Corynebacterium pseudotuberculosis . An ideal vaccine for CLA is necessary for the disease control .

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“…Sheep vaccinated twice with 100 µg per dose of CP40 in aluminum hydroxide adjuvant were protected against infection with Cps, with an 82% reduction in the number of infected sheep and a 98% reduction in lung lesions, suggesting that the 40-kDa antigen plays a major role in immunity to CLA [96]. Another antigens have been tested but were found with lower effects [97].…”

Section: Vaccinationmentioning

confidence: 99%

Morel’s Disease and Caseous Lymphadenitis: a Literature Review with Special Reference to Saudi Arabia

Saeed¹,

Alharbi²

2014

IOSRJAVS

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Protection in alpacas against Corynebacterium pseudotuberculosis using different bacterial components

Cited by 15 publications

References 13 publications

Frequency of caseous lymphadenitis (CLA) in sheep slaughtered in an abattoir in Tabriz: comparison of bacterial culture and pathological study

Frequency of caseous lymphadenitis (CLA) in sheep slaughtered in an abattoir in Tabriz: comparison of bacterial culture and pathological study

Vaccines for caseous lymphadenitis: up-to-date and forward-looking strategies

Morel’s Disease and Caseous Lymphadenitis: a Literature Review with Special Reference to Saudi Arabia

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