Protection of cardiomyocyte function by propofol during simulated ischemia is associated with a direct action to reduce pro-oxidant activity

McDermott, Barbara; McWilliams, Stewart; Smyth, Karen; Kelso, Elizabeth; Spiers, Paul; Zhao, Yifang; Bell, David; Mirakhur, R. K.

doi:10.1016/j.yjmcc.2006.12.002

Cited by 22 publications

(19 citation statements)

References 42 publications

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“…This study shows that propofol dose-dependently decreases H 2 O 2 -treated cardiomyocytes MDA content and limits the depletion of SOD, which support the widely held view that propofol is protective because of its ability to act as a free radical scavenger in its own right [5] and possibly also enhance the tissue's own antioxidant capacity [7,10]. We also demonstrated that H 2 O 2 cytotoxicity in cardiomyocytes is significantly attenuated by propofol in a dose-dependent manner.…”

Section: Discussionsupporting

confidence: 86%

“…Furthermore, some researches have demonstrated that propofol can attenuate the toxicity of H 2 O 2 in cardiomyocytes [9,10]. It has been suggested that the cardioprotection of propofol may partly result from its ability to act as a free radical scavenger [5], enhancing tissue antioxidant capacity [7,10], or through inhibition of plasma membrane calcium channels [11].…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that the cardioprotection of propofol may partly result from its ability to act as a free radical scavenger [5], enhancing tissue antioxidant capacity [7,10], or through inhibition of plasma membrane calcium channels [11]. Nevertheless, the precise mechanism that modulates this response is still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1

Wang

2008

European Journal of Anaesthesiology

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1

Wang

2008

European Journal of Anaesthesiology

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“…[4, 5] Propofol also has the anti-inflammatory and anti-oxidant effects. [6, 7] It has been proven that propofol can inhibit the adhesion of neutrophil to vascular endothelial cells, scavenge oxygen free radicals, alleviate oxidative damage, and decrease the release of inflammatory cytokines such as TNF-α, IL-6 and IL-1β. [8–10] Clinically used concentrations of propofol are reported to promote apoptosis and inhibit the invasion of human cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application

et al. 2016

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Anesthetics are unavoidable to colorectal cancer (CRC) patients who underwent surgical treatment. Thus, the molecular mechanisms underlying the role of the intravenous anesthetics in CRC metastasis are still unclear. In this study, the effects of intravenous anesthetics, such as propofol, etomidate and dexmedetomidine, on cell migration were determined. The migration of CRC cells was inhibited by propofol in vitro, but not in vivo. Etomidate, however, promoted the migration of CRC cells both in vitro and in vivo. Epithelial-mesenchymal transition (EMT) mediated the promotive effect of propofol and etomidate on the migration of CRC cells through PI3K/AKT signaling pathway. Dexmedetomidine alone or in combination with propofol or etomidate had minor effect on the migration of CRC cells. These findings indicate that propofol inhibites CRC cell migration in vitro. Etomidate playes a role for prompting CRC metastasis progression by activating (PI3K)/AKT signaling and inducing EMT. It provides an important hint for the clinical application of these anesthetics.

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“…A review of the medical literature reveals that the effects of propofol on myocardial stunning after transient ischemia have not been properly investigated, and that in vivo it was far from being advantageous, [8,9,11,12,14,[16][17][18]32] even though there is some evidence (mostly in in vitro studies) for its potential to protect the ischemic myocardium. [13,15,[33][34][35][36][37][38] The purpose of this study was to compare the effects of propofol vs isoflurane in a porcine model of acute coronary occlusion, imitating postischemic reversible contractile dysfunction conditions that may appear in off-pump cardiac surgery. We investigated the hypothesis that volatile anesthetic isoflurane improves global myocardial function, following transient coronary occlusion and reperfusion when compared to the short-acting intravenous anesthetic, propofol.…”

Section: Introductionmentioning

confidence: 99%

Treating myocardial stunning randomly, with either propofol or isoflurane following transient coronary occlusion and reperfusion in pigs

et al. 2009

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Propofol and isoflurane may be used during fast track anesthesia for off-pump bypass, where transient ischemia is common. The purpose of this study was to compare the effects of propofol vs isoflurane in a porcine model of acute coronary occlusion. Twenty five pigs were randomized to receive general anesthesia with either isoflurane, 1 MAC (n = 13), or propofol, 3 mg/kg bolus followed by 200 microg/ kg/min infusion (n = 12). Pressure-tipped catheters were placed in the left ventricle (LV) and carotid artery; cardiac output was measured by ultrasound; two pairs of ultrasonic dimension catheters were placed in the subendocardium of LV. The slope of LV end-systolic pressure-volume relationship (Emax) was calculated. Reversible ischemia for 15 mins was accomplished with an occluder around the left anterior descending artery followed by reperfusion period. Measurements were done at baseline, end ischemia, early (5 min) and late (30 min) reperfusion. The data collected included systemic hemodynamics, LV end-diastolic pressure (LVEDP), dP/dt, Emax, and the presence of ventricular arrhythmias. The number of animals studied to completion was 19 (n = 11 in the isoflurane group; n = 8 in propofol group). There was a significant difference in Emax between isoflurane and propofol during early and late reperfusion [3.4 (0.5) and 4.0 (0.3) vs 2.6 (0.4) and 3.2 (0.5) mmHg/sec, respectively; P < 0.05]. Postreperfusion ventricular fibrillation occurred in 54% animals in the propofol group vs none in the isoflurane group ( P 0.05). Isoflurane administration was found to be cardioprotective against ventricular depression and arrhythmias compared to propofol.

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Protection of cardiomyocyte function by propofol during simulated ischemia is associated with a direct action to reduce pro-oxidant activity

Cited by 22 publications

References 42 publications

Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1

Propofol attenuation of hydrogen peroxide-mediated oxidative stress and apoptosis in cultured cardiomyocytes involves haeme oxygenase-1

Differential role of intravenous anesthetics in colorectal cancer progression: implications for clinical application

Treating myocardial stunning randomly, with either propofol or isoflurane following transient coronary occlusion and reperfusion in pigs

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