Protection of Chickens with Maternal Immunity Against Avian Influenza Virus (AIV) by Vaccination with a Novel Recombinant Newcastle Disease Virus Vector

Murr, Magdalena; Grund, Christian; Breithaupt, Angele; Mettenleiter, Thomas C.; Römer-Oberdörfer, Angela

doi:10.1637/aviandiseases-d-20-00014

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…Second, the “antigen decoy” strategy for antagonizing interference from foreign antigens was recently reported. Using the H5 subtype AIV as a model, haemagglutinin (HA) has been expressed in the full-length and secreted versions in the NDV vector [ 85 ]. The secreted form acts as a decoy that can absorb a fraction of the pre-existing HA-specific antibodies.…”

Section: Commercial Nd Vaccinesmentioning

confidence: 99%

Current situation and future direction of Newcastle disease vaccines

Deng

et al. 2022

Vet Res

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Newcastle disease (ND) is one of the most economically devastating infectious diseases affecting the poultry industry. Virulent Newcastle disease virus (NDV) can cause high mortality and severe tissue lesions in the respiratory, gastrointestinal, neurological, reproductive and immune systems of poultry. Tremendous progress has been made in preventing morbidity and mortality caused by ND based on strict biosecurity and wide vaccine application. In recent decades, the continual evolution of NDV has resulted in a total of twenty genotypes, and genetic variation may be associated with disease outbreaks in vaccinated chickens. In some countries, the administration of genotype-matched novel vaccines in poultry successfully suppresses the circulation of virulent NDV strains in the field. However, virulent NDV is still endemic in many regions of the world, especially in low- and middle-income countries, impacting the livelihood of millions of people dependent on poultry for food. In ND-endemic countries, although vaccination is implemented for disease control, the lack of genotype-matched vaccines that can reduce virus infection and transmission as well as the inadequate administration of vaccines in the field undermines the effectiveness of vaccination. Dissection of the profiles of existing ND vaccines is fundamental for establishing proper vaccination regimes and developing next-generation vaccines. Therefore, in this article, we provide a broad review of commercial and experimental ND vaccines and promising new platforms for the development of next-generation vaccines.

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Section: Commercial Nd Vaccinesmentioning

confidence: 99%

Current situation and future direction of Newcastle disease vaccines

Deng

et al. 2022

Vet Res

View full text Add to dashboard Cite

show abstract

“…They speculated that elevated antigen levels may enhance antigenicity of HA, which may overwhelm the interference of AIV-MDA. In a following study, AIV-MDA + chickens at different ages were vaccinated with the rNDVsolH5_H5 and the vaccine provided full protection against AIV challenge in 3-week-old chickens (Murr et al, 2020a). The vaccine provided 40 and 85% protection in younger chickens with higher AIV-MDA at 1 and 2 weeks post hatch, while it still strongly reduced shedding of challenge virus.…”

Section: Expression Of Soluble Antigens In Ndv Vector As Decoysmentioning

confidence: 96%

“…The GOI, especially the virus surface glycoproteins, incorporated into NDV virions may be also involved in virus attachment to the cells and virus life cycle. A recent study demonstrated that a recombinant NDV co-expressing soluble and membrane-bound H5 HAs replicated efficiently in chickens with high AIV-MDA titers, indicating no inhibition of AIV-MDA on vaccine virus replication (Murr et al, 2020a). However, there was no direct evidence elucidating the role of the GOI in replication of vectored vaccines.…”

Section: Mda Interference With Ndv-vectored Vaccinesmentioning

confidence: 99%

“…However, no such studies were performed to evaluate the effect of this combination on the immunogenicity and efficacy of the vectored vaccines in the presence of MDA against both the vector and GOI. Additionally, Murr et al revealed that the NDV vector coexpressing soluble and membrane-bound H5 HA only provided 40% protection in 1-week-old chickens with high HI antibody titers of ∼4 log 2 (Murr et al, 2020a), indicating that further elevation of HA yield may be required to overcome high levels of MDA. Therefore, some points should be considered to optimize the effect of this combination.…”

Section: Efficacy Of Virus Vectors Expressing Soluble Antigens: No Consensus Yetmentioning

confidence: 99%

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