Protection of DAergic neurons mediates treadmill running attenuated olfactory deficits and olfactory neurogenesis promotion in depression model

Tian, Yuan; Dong, Jing; Dong-bo, Shi

doi:10.1016/j.bbrc.2019.10.158

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…More recent studies, however, have demonstrated increased neurogenesis in the subventricular zone. One group used treadmill running in a mouse model of depression generated via chronic unpredictable mild stress, preventing dopaminergic neuron loss in the glomerular layer and improving olfactory function (Tian et al 2020). Other studies have observed rescue effects of wheel running on neural stem cells that were made defective by genetic manipulation or chronic corticosterone infusion (Brown et al 2003;Mastrorilli et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice

Chelette

Loeven

Gatlin

et al. 2021

The Journal of Physiology

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Section: Discussionmentioning

confidence: 99%

Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice

Chelette

Loeven

Gatlin

et al. 2021

The Journal of Physiology

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“…In rodents, voluntary wheel running mimics long-term regular aerobic exercise with adequate oxygen supply ( Manzanares et al, 2018 ). More intriguingly, aerobic exercise has been found to promote α-syn clearance and improve recovery of olfactory function ( Koo and Cho, 2017 ; Tian et al, 2020 ). This finding has prompted our interest in exploring the effect of aerobic exercise on the potential impairment of olfactory function caused by chronic Meth administration.…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Improves Methamphetamine-Induced Olfactory Dysfunction Through α-Synuclein Intervention in Male Mice

Wang

Zheng

Wang

et al. 2022

Front. Mol. Neurosci.

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Methamphetamine (Meth) is a predominantly abused neurostimulant, and its abuse is often associated with multiple neurological symptoms. Olfaction, the sense of smell, is a highly neurotransmission-dependent physiological process; however, the effect of Meth on olfactory function and its underlying mechanisms remain largely unknown. This study aimed to explore the impact of Meth abuse on the olfactory system and the potential mechanisms. Chronic Meth abuse was induced by daily administration of Meth in male mice for 4 weeks, and we then systematically examined olfactory performance. Behavioral tests found that Meth-treated animals showed increased olfactory threshold, decreased olfactory sensitivity, reduced olfactory-dependent discrimination, and difficulty in seeking buried food. Notably, the increased deposition of α-synuclein (α-syn) in the olfactory bulb was detected. Adeno-associated virus (AAV)-mediated α-syn intervention therapy in the olfactory bulb significantly alleviated Meth-induced olfactory function impairment, and 8 weeks of aerobic exercise showed similar effects through the same principle of α-syn intervention. Notably, exercise-mediated reduction of α-syn inhibited abnormal firing activity and restored the inhibitory synaptic regulation of mitral cells in the olfactory bulb. These findings suggest the involvement of α-syn in the pathogenic mechanisms of Meth-induced olfactory dysfunction and shed light on the possible therapeutic applications of aerobic exercise in Meth-induced olfactory dysfunction.

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“…Evidence suggests that 4 weeks of aerobic exercise significantly reduces the immobility time in the forced swim test (FST), increases sucrose preference and significantly reduces the immobility time and total distance travelled in the open field test (OFT) in rats with chronic unpredictable mild stress-induced post-stroke depression (Luo et al, 2019). Furthermore, 8 weeks of running training can significantly reduce the immobility time and increase the swimming and climbing time in FST in OVX mice or rats with chronic stress (Han et al, 2015;Kang et al, 2020;Tian et al, 2020) and increase the proportion of sucrose consumed (Tian et al, 2020). Additionally, 14 days of aerobic training can decrease the immobility time and increase the normal swimming time in FST in chronic unpredictable mild stress (CUMS)-induced rats (Kang et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Estrogen receptors mediate the antidepressant effects of aerobic exercise: A possible new mechanism

Zhou

Wang

Zhou

et al. 2022

Front. Aging Neurosci.

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PurposeThis study aimed to examine whether aerobic exercise exerts mood-modulating effects through an estrogen signaling mechanism.MethodThe experiment was divided into two parts. The first part is to compare the three modeling methods to obtain the most obvious method of depression-like phenotype for further study in the second part. The first part of ovariectomized rats (age, 13 weeks) was tested when rats were 14 or 22 weeks old or in the sixth week after 3 weeks of chronic restraint stress. The second part was to treat the animals with the most obvious depression-like phenotype in different ways, placebo treatment or estradiol (E2) replacement therapy was administered, aerobic training, or estrogen receptor antagonist treatment. The cognitive (Barnes maze and 3-chamber social tests), anxiety-like (open-field and elevated plus maze tests) and depression-like (sucrose preference and forced swim tests) behaviors of rats in both parts were analyzed to study the effects of estrogen depletion and aerobic exercise.ResultsRats did not develop depressive symptoms immediately after ovariectomy, however, the symptoms became more pronounced with a gradual decrease in ovarian hormone levels. Compared with the placebo or control groups, the exercise and E2 groups showed improved performance in all behavioral test tasks, and the antidepressant effects of aerobic exercise were comparable to those of estrogen. Moreover, the estrogen receptor antagonist has markedly inhibited the antidepressant effects of aerobic exercise.ConclusionEstrogen receptors may mediate the antidepressant effects of aerobic exercise. In addition, an increasingly fragile ovarian hormonal environment may underlies chronic restraint stress-induced depression.

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Protection of DAergic neurons mediates treadmill running attenuated olfactory deficits and olfactory neurogenesis promotion in depression model

Cited by 5 publications

References 28 publications

Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice

Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice

Aerobic Exercise Improves Methamphetamine-Induced Olfactory Dysfunction Through α-Synuclein Intervention in Male Mice

Estrogen receptors mediate the antidepressant effects of aerobic exercise: A possible new mechanism

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