Protection of Parathyroid Function Using Carbon Nanoparticles during Thyroid Surgery

Huang, Kai; Luo, Dong-Hua; Huang, Mingqing; Long, M. Louisa; X, Peng; Li, Honghao

doi:10.1177/0194599813509779

Cited by 39 publications

(54 citation statements)

References 18 publications

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“…Some previous studies have demonstrated that CNs are beneficial for visualizing the lymph nodes and for distinguishing and preserving the parathyroid glands. On the contrary, other studies found no advantage of CNs 18,24. In addition, some indexes, such as postoperative hypocalcemia, are easily influenced by confounding factors such as the postoperative therapeutic selection, calcium supplements, and individual differences.…”

Section: Resultsmentioning

confidence: 93%

Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis

Wang¹,

Yang²,

Lv³

et al. 2017

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PurposeTo investigate whether carbon nanoparticles (CNs) are helpful in identifying lymph nodes and metastatic lymph nodes and in parathyroid protection during thyroid cancer surgery.MethodsEnglish and Chinese literature in PubMed, Cochrane Database of Systematic Reviews, EMBASE, ClinicalTrials.gov, China Biology Medicine Database, China National Knowledge Infrastructure, China Master’s and Doctoral Theses Full-Text Database, Wanfang database, and Cqvip database were searched (till March 22, 2016). Randomized controlled trials (RCTs) that compared the use of CNs with a blank control in patients undergoing thyroid cancer surgery were included. Quality assessment and data extraction were performed, and a meta-analysis was conducted using RevMan 5.1 software. The primary outcomes were the number of retrieved central lymph nodes and metastatic lymph nodes, and the rate of accidental parathyroid removal.ResultsWe obtained 149 relevant studies, and only 47 RCTs with 4,605 patients (CN group: n=2,197; blank control group: n=2,408) met the inclusion criteria. Compared with the control group, the CN group was associated with more retrieved lymph nodes/patient (weighted mean difference [WMD]: 3.39, 95% confidence interval [CI]: 2.73–4.05), more retrieved metastatic lymph nodes (WMD: 0.98, 95% CI: 0.61–1.35), lower rate of accidental parathyroid removal, and lower rates of hypoparathyroidism and hypocalcemia. However, the total metastatic rate of the retrieved lymph nodes did not differ between the groups (odds ratio: 1.13, 95% CI: 0.87–1.47, P=0.35).ConclusionCNs can improve the extent of neck dissection and protect the parathyroid glands during thyroid cancer surgery. And the number of identified metastatic lymph nodes can be simultaneously increased.

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Section: Resultsmentioning

confidence: 93%

Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis

Wang¹,

Yang²,

Lv³

et al. 2017

OTT

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“…In consideration of the ideal effects and low side effects, carbon nanoparticles have been used in different kinds of cancer operations, like breast cancer [18], thyroid cancer [19], and colorectal cancer [11]. At present, carbon nanoparticles have been used more widely in China [18, 19, 34].…”

Section: Discussionmentioning

confidence: 99%

“…At present, carbon nanoparticles have been used more widely in China [18, 19, 34]. In our study, we localized colorectal cancer and traced lymph nodes with carbon nanoparticle suspension to evaluate their effectiveness in laparoscopic colorectal resection.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, with the development of nanotechnology, carbon nanoparticles have been widely used for tumor tattooing and lymph node tracing [11, 18, 19]. An injection of carbon nanoparticle suspension comprises nanosized carbon particles with an average diameter of 150 nm.…”

Section: Introductionmentioning

confidence: 99%

“…These particles enter the lymphatic vessels rather than the blood vessels. Owing to their ideal effects and few side effects, carbon nanoparticles have been used in different kinds of surgeries for different cancers, such as breast cancer [18], thyroid cancer [19], and colorectal cancer [11]. However, studies that focus on laparoscopic colorectal surgery are few.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by using carbon nanoparticles in laparoscopy

et al. 2016

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BackgroundThe objective of this study is to evaluate the effectiveness of preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by carbon nanoparticle tattooing in laparoscopic colorectal cancer surgery.MethodsFrom January 2013 to December 2014, 54 patients with colorectal cancer were recruited and divided into experimental (n = 27) and control (n = 27) groups. The patients in the experimental group were localized preoperatively by endoscopic carbon nanoparticle tattooing, whereas patients in the control group were not tattooed.ResultsAll injection sites in the experimental group were visible to surgeons. No abdominal pain, fever, diarrhea, and other symptoms of infection were found in the experimental group. The time for detecting the tumor (2.71 ± 2.13 min versus 6.91 ± 5.16 min, p < 0.001), operation time (151.22 ± 30.66 min versus 170.26 ± 33.13 min, p = 0.033), and blood loss during the operation (125.04 ± 29.48 mL versus 147.52 ± 34.35 mL, p = 0.013) were lower in the experimental group than in the control group. Average numbers of dissected lymph nodes in the experimental group exceeded those in the control group (14.41 ± 3.32 versus 8.96 ± 2.90, p < 0.001), and the rate of dissected lymph nodes ≥12 was higher in the experimental group than in the control group (70.37 versus 37.04 %, p < 0.001). Moreover, no difference in postoperative complications was found between the two groups.ConclusionsTattooing colorectal cancer with carbon nanoparticles in laparoscopic colorectal cancer surgery is safe and useful both in localization and lymph node tracing.

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Carbon nanoparticle–guided central lymph node dissection in clinically node‐negative patients with papillary thyroid carcinoma

et al. 2015

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Protection of Parathyroid Function Using Carbon Nanoparticles during Thyroid Surgery

Cited by 39 publications

References 18 publications

Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis

Application of carbon nanoparticles in lymph node dissection and parathyroid protection during thyroid cancer surgeries: a systematic review and meta-analysis

Preoperative endoscopic localization of colorectal cancer and tracing lymph nodes by using carbon nanoparticles in laparoscopy

Carbon nanoparticle–guided central lymph node dissection in clinically node‐negative patients with papillary thyroid carcinoma

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