Protective abilities of pyridoxine in experimental oxidative stress settings in vivo and in vitro

Danielyan, Kristine Edgar; Simonyan, Armen Arshaluys

doi:10.1016/j.biopha.2016.12.053

Cited by 16 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…), one‐carbon unit metabolism, and so on. [ 9 ] Reports suggested that vitamin B supplementation (including Vit B 6 ) slows the rate of brain atrophy, regulates brain glucose metabolism, decreases oxidative stress levels, and confer many protective effects against brain disorders. [ 9,10 ]…”

Section: Introductionmentioning

confidence: 99%

“…[9] Reports suggested that vitamin B supplementation (including Vit B 6 ) slows the rate of brain atrophy, regulates brain glucose metabolism, decreases oxidative stress levels, and confer many protective effects against brain disorders. [9,10] The brain has the highest oxygen consumption ratio among all other organs. It has high oxygen demand and a high risk of reactive oxygen species (ROS) production.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Türkyılmaz

Altaş

Arisan

et al. 2021

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Valproic acid (VPA) is an efficient antiepileptic drug widely used for the treatment of epilepsy and other seizures in both children and adults. It is also reported to have side and toxic effects on many organs and tissues. Vitamin B 6 (Vit B 6 ) is a welldescribed water-soluble vitamin, which has an antioxidant effect. In this study, we aimed to investigate the protective effect of Vit B 6 on VPA-induced brain injury.Male Sprague-Dawley rats were divided into four groups. Group I, control animals;Group II, Vit B 6 (50 mg/kg/day) given rats; Group III, VPA (500 mg/kg/day) given rats; Group IV, VPA and Vit B 6 given rats at same dose and time. VPA and Vit B 6 were administered intraperitoneally and orally, respectively, for 7 days. At the end of the experiments, the rats were sacrificed and brain tissues were taken. Protein carbonyl and sialic acid levels, xanthine oxidase, adenosine deaminase, acetylcholine esterase, lactate dehydrogenase, myeloperoxidase activities, total oxidant status, and reactive oxygen species levels were found to be increased, while glutathione and total antioxidant capacity levels, catalase, superoxide dismutase, glutathione-Stransferase, paraoxonase, and glutathione reductase activities were found to be decreased in the VPA group. Administration of Vit B 6 reversed these defects in the VPA group. These findings indicate that Vit B 6 has a protective effect on VPAinduced brain damage.

show abstract

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Türkyılmaz

Altaş

Arisan

et al. 2021

J Biochem & Molecular Tox

View full text Add to dashboard Cite

show abstract

“…Another previous study with Japanese women demonstrated that VB 6 plays a role against oxidative DNA damage, but not folate and homocysteine 32 . One of the possible reasons for our results is the ability of VB 6 to inhibit xanthine oxidase activity, which is an enzyme responsible for the formation of uric acid and hydrogen peroxide 33 . The detoxification of xenobiotics seems to be related with the GST enzyme and is regulated by NRF2.…”

Section: Discussionmentioning

confidence: 92%

Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…This ROS may have an inhibitory effect on the M. chimaera ECMO due to its susceptibility to them [53]. Thirdly, it has been reported that the pyridoxine present in the growth broth used inhibits the action of certain xanthine oxidases, e.g., human xanthine oxidase [54]. This "hijacking" by the xanthine oxidase would reduce the concentration of pyridoxine, which in turn would reduce the mycobacterial growth rate because it is necessary for the correct growth of certain mycobacteria [55].…”

Section: Discussionmentioning

confidence: 99%

Contact Effect of a Methylobacterium sp. Extract on Biofilm of a Mycobacterium chimaera Strain Isolated from a 3T Heater-Cooler System

et al. 2020

View full text Add to dashboard Cite

Mycobacterium chimaera is an opportunistic slowly growing non-tuberculous mycobacteriumof increasing importance due to the outbreak of cases associated with contaminated 3T heater-cooler device (HCD) extracorporeal membrane oxygenator (ECMO). The aim of this study was to evaluate the effect of pre-treating a surface with a Methylobacterium sp. CECT 7180 extract to inhibit the M. chimaera ECMO biofilm as well as of the treatment after different dehydration times. Surface adherence, biofilm formation and treatment effect were evaluated by estimating colony-forming units (CFU) per square centimeter and characterizing the amount of covered surface area, thickness, cell viability, and presence of intrinsic autofluorescence at different times using confocal laser scanning microscopy and image analysis. We found that exposing a surface to the Methylobacterium sp. CECT 7180 extract inhibited M. chimaera ECMO biofilm development. This effect could be result of the effect of Methylobacterium proteins, such as DNaK, trigger factor, and xanthine oxidase. In conclusion, exposing a surface to the Methylobacteriumsp. extract inhibits M. chimaera ECMO biofilm development. Furthermore, this extract could be used as a pre-treatment prior to disinfection protocols for equipment contaminated with mycobacteria after dehydration for at least 96 h.

show abstract

Protective abilities of pyridoxine in experimental oxidative stress settings in vivo and in vitro

Cited by 16 publications

References 17 publications

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

Contact Effect of a Methylobacterium sp. Extract on Biofilm of a Mycobacterium chimaera Strain Isolated from a 3T Heater-Cooler System

Contact Info

Product

Resources

About

Protective abilities of pyridoxine in experimental oxidative stress settings in vivo and in vitro

Cited by 16 publications

References 17 publications

Effect of vitamin B6on brain damage in valproic acid induced toxicity

Effect of vitamin B6on brain damage in valproic acid induced toxicity

Effects of Isolated Vitamin B6 Supplementation on Oxidative Stress and Heart Function Parameters in Experimental Hyperhomocysteinemia

Contact Effect of a Methylobacterium sp. Extract on Biofilm of a Mycobacterium chimaera Strain Isolated from a 3T Heater-Cooler System

Contact Info

Product

Resources

About

Effect of vitamin B₆on brain damage in valproic acid induced toxicity

Effect of vitamin B₆on brain damage in valproic acid induced toxicity