Protective activity of flavonoid and flavonoid glycosides against glucose-mediated protein damage

Kim, Ho; Lee, Jeong Min; Yokozawa, Takako; Sakata, Kiyoka; Lee, Sang‐Hyun

doi:10.1016/j.foodchem.2010.11.068

Cited by 37 publications

(20 citation statements)

References 29 publications

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“…Thus, it may be postulated that white kidney bean extract can inhibit glycation by various strategies (i) blocking the early glycation product (fructosamine), (ii) reducing the generation of reactive carbonyl or dicarbonyl groups either from fructosamine or glucose, and (iii) inhibiting the AGEs formation. These results are supported by similar findings where quercetin and kaempferol (flavonol aglycones) found in white kidney bean extract suppressed in vitro AGEs formation (Kim et al, 2011) with antiinflammatory activity by reducing reactive species.…”

Section: Discussionsupporting

confidence: 86%

Nutraceutical properties of dietary plants extracts: Prevention of diabetic nephropathy through inhibition of glycation and toxicity to erythrocytes and HEK293 cells

Tupe

Sankhe

Shaikh

et al. 2014

Pharmaceutical Biology

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Context: Glycated albumin is reported to elicit pathobiologic effects in diabetic nephropathy and abrogating its biologic effects has novel therapeutic potential. Objective: This study examines the effects of dietary plants extracts (Laurus nobilis, Carum carvi, Coccinia grandis, Mentha arvensis, Phaseolus vulgaris) against albumin glycation and its toxicity to erythrocytes and HEK293 cells. Materials and methods: Albumin (10 mg/ml) was incubated with fructose (250 mM) in PBS along with aqueous plant extracts (1% w/v) for 4 d. After incubation, the antiglycation potential of extracts was estimated by measuring AGEs, fructosamine, amyloids, carbonyls, free amino groups, and antioxidant potential of albumin. The glycation extent of the treated samples was determined by boronate affinity chromatography. Effect of extracts against glycation induced cytotoxicity in erythrocytes and HEK 293 cells was assessed by estimating viability, glutathione, and antioxidant capacity. Plant extracts were tested for their phenolic content and antioxidant potential (reducing potential, DPPH, ABTS, NO, and H 2 O 2 radical scavenging activities). Results: Plant extracts significantly decreased the AGEs formation and amyloid aggregation in glycated BSA (p50.001). Further, fructosamine and carbonyls were reduced to 55-72% and 83-89%, respectively. Free amino group and antioxidant activity of albumin were also preserved by 1.25-1.40-fold and 1.75-1.8-fold, respectively. Further, co-incubation of extracts with glycated albumin, protected erythrocytes, and HEK293 cells as they inhibited cellular hemolysis/toxicity (p50.001) by upregulating cellular antioxidants. Discussion and conclusion: Plant co-incubation reversed many modifications in albumin glycation, cellular dysfunction indicating that dietary sources with antiglycating and antioxidant potential could be considered for the effective management of diabetic nephropathy.

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Section: Discussionsupporting

confidence: 86%

Nutraceutical properties of dietary plants extracts: Prevention of diabetic nephropathy through inhibition of glycation and toxicity to erythrocytes and HEK293 cells

Tupe

Sankhe

Shaikh

et al. 2014

Pharmaceutical Biology

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“…In apple pomace besides these components, the role of quercetin glycosides is important. Indeed, quercetin glycosides were shown to strongly inhibit protein glycation (Kim, Lee, Yokozawa, Sakata, & Lee, 2011). The effect of the drying procedure on both the overall radical-scavenging activity and the antiglycation activity was not significant (p > 0.05).…”

Section: Resultsmentioning

confidence: 96%

Phloridzin and other phytochemicals in apple pomace: Stability evaluation upon dehydration and storage of dried product

Lavelli

Corti

2011

Food Chemistry

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“…19 As mentioned earlier, 5 kaemferol (13) and quercetin (20) also exhibited protective effect to glycation 48 and showed in vitro protection against protein damage. 55 In another study, quercetin-3glucospyranoside (32) has been found to exhibit broad range of bioactivities. It was isolated from Cordia sinensis as one of the potent antiglycation agent and also exhibited anti-inflammatory and antioxidant properties.…”

Section: Phytochemicals With Anti-glycation Activitymentioning

confidence: 97%

“…39 25 Triterpenoids with wide structural diversity have been reported to exhibit antiglycation activity. Oleanolic acid (3), a pentacyclic triterpene carboxylic acid along with two phenolic acids, caffeic acid (52) and chlorogenic acid (55) from Ilex paraguariensis, contributed to the antiglycation activity. The effect was found to be more potent than the 30 anti-glycation effect of standard AMG, a well known anti-glycation agent.…”

Section: Phytochemicals With Anti-glycation Activitymentioning

confidence: 99%

Recent development of plant products with anti-glycation activity: a review

et al. 2015

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Protective activity of flavonoid and flavonoid glycosides against glucose-mediated protein damage

Cited by 37 publications

References 29 publications

Nutraceutical properties of dietary plants extracts: Prevention of diabetic nephropathy through inhibition of glycation and toxicity to erythrocytes and HEK293 cells

Nutraceutical properties of dietary plants extracts: Prevention of diabetic nephropathy through inhibition of glycation and toxicity to erythrocytes and HEK293 cells

Phloridzin and other phytochemicals in apple pomace: Stability evaluation upon dehydration and storage of dried product

Recent development of plant products with anti-glycation activity: a review

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