Protective and anti-inflammatory effects of silymarin on paraquat-induced nephrotoxicity in rats

Sharifi-Rigi, Ali; Heidarian, Esfandiar

doi:10.15171/jhp.2019.05

Cited by 6 publications

(2 citation statements)

References 39 publications

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“…Vitamin C is an important nonenzymatic antioxidant known to protect cells of the body against oxidants. The inclusion of vitamin C as one of the supplements in the present study was due to previous reports which indicated that PQ and some xenobiotics induce low vitamin C levels, and this causes renal toxicity [28,29]. The present study shows that vitamin C treated group presented significantly reduced MDA, urea, creatinine, uric acid, triacylglyceride, and LDL-cholesterol.…”

Section: Discussionsupporting

confidence: 57%

Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats

Ujowundu

Anaba

Ulinasombu

et al. 2020

Innov Biosyst Bioeng

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Background. Paraquat (PQ) is a pesticide commonly used in the control of weed in agricultural practices worldwide. Exposure to PQ has adverse biochemical and physiological consequences to humans and animals. The mechanism of toxicity is linked to the generation of reactive oxygen species and subsequent lipid peroxidation. Presently, no single effective antidote to PQ toxicity has been established. Therefore, the need to continually investigate different treatment approaches is of paramount importance. Objective. This study evaluated the capacity of selected dietary supplements to attenuate paraquat-induced kidney dysfunction and damages by determining some kidney function biomarkers and oxidative parameters. Methods. Thirty-six Wistar albino rats were randomly separated into six groups. Each group (except Normal control) was intoxicated every other day with 1.5 mg/kg body weight of PQ and four groups (except PQ and Normal control groups) were treated daily with 40 mg/kg of garlic, glutathione and vitamin C for two weeks. Results. The results showed significant (p  0.05) increases in concentration of kidney malondialdehyde, urea, creatinine, and blood lipid profiles. Also, significant decrease in concentrations of high-density lipoprotein cholesterol, kidney glutathione and total antioxidant capacity were presented by PQ control group compared to other PQ exposed groups treated with the antioxidant compounds. Conclusions. PQ-induced changes indicated kidney dysfunction and damage. However, the administration of antioxidant supplements attenuated the PQ-induced biochemical and physiological dysfunction in the rats.

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Section: Discussionsupporting

confidence: 57%

Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats

Ujowundu

Anaba

Ulinasombu

et al. 2020

Innov Biosyst Bioeng

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“…Silybum marianum is a member of Asteraceae family, it is used to treat liver disease as a hepatoprotective herb. [18]. The hepatoprotective effect of silymarin is attributed to its dosedependent antioxidant effect.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ginger Nanoparticles on Hepato-renal Toxicity Induced by Carbon Tetrachloride in Rats

Elrhman

Fattah

Morsy

et al. 2020

ARRB

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Aims: The current study was developed to investigate the influence of ginger (G), ginger nanoparticles (GNPs) and ginger nano-base (GNB) on hepato-renal toxicity induced by carbon tetrachloride (CCl4) in rats in comparison with silymarin (SM). Place and Duration of Study: Department of Biochemistry and Nutrition, Faculty of Women for Arts, Science and Education, Ain Shams University. Methodology: Fifty-four adult male Sprague-Dawley rats were divided into 6 groups. Group (1): Rats received distilled water orally and injected intraperitoneally (i.p.) with single dose of corn oil (1 ml/kg b.wt). Group (2): Rats were injected with single dose of CCl4 diluted with corn oil (1:1) (1 ml/kg b.wt. i.p.) at the 4th week of experiment. Groups (3), (4) and (5): Rats were orally received 50 mg /kg b.wt./day of G, GNPs and GNB, respectively for 8 weeks and injected with CCl4 as group 2. Group (6): Rats were orally received 100 mg /kg b.wt /day of SM for 8 weeks and injected with CCl4 as group 2. Results: Our results documented that injection with CCl4 caused significant increase (p<0.05) in liver function tests [serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities], kidney function tests [serum creatinine, urea, uric acid and cystatin C] and serum levels of malondialdehyde (MDA), Nitric oxide (NO), tumor necrosis factor- alpha (TNF- α) and interleukin 1 beta (IL-1β). On the other hand, there was a significant decrease (p<0.05) in the serum total antioxidant capacity (TAC), Hepatic catalase (CAT) and superoxide dismutase (SOD) enzymes activity, with histopathological changes in liver and kidneys tissues. Oral administration of G, GNPs, GNB and SM caused an enhancement of liver and kidney function, decreasing serum oxidants and inflammatory markers levels while increasing the activities of antioxidant enzymes, also an improvement of organs histopathological changes was observed. Conclusion: Our data proved that using ginger in the form of GNPs and GNB are more efficient in ameliorating hepato-renal toxicity induced by CCl4 than using native ginger as evidenced by biochemical analysis and histological examination of liver and kidneys tissues.

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Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats

Nouri

Heibati

Heidarian

2020

Naunyn-Schmiedeberg's Arch Pharmacol

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Protective and anti-inflammatory effects of silymarin on paraquat-induced nephrotoxicity in rats

Cited by 6 publications

References 39 publications

Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats

Attenuation of Paraquat-Induced Nephrotoxicity and Dysfunction in Male Wistar Albino Rats

Effect of Ginger Nanoparticles on Hepato-renal Toxicity Induced by Carbon Tetrachloride in Rats

Gallic acid exerts anti-inflammatory, anti-oxidative stress, and nephroprotective effects against paraquat-induced renal injury in male rats

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