Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen

Chidambaram, Kumarappan; Vijayakumar, M.; Thilagam, Ellappan; Balamurugan, M.; Madheswaran, Thiagarajan; Senthil, S.; Das, Sunil C.; Mandai, Subhash C

doi:10.1016/s1665-2681(19)31589-3

Cited by 23 publications

(14 citation statements)

References 27 publications

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“…However, the different doses of the YL and OL extracts histopathologically showed evidence of hepatoprotective abilities, with the 30 mg/kg YL and 300 mg/kg of both YL and OL, showing the highest curative effect in the hepatocytes of the liver. This finding is comparable to research works elsewhere [16, 26, 30, 39], where medicinal plant extracts demonstrated the ability to enhance repair of hepatocellular damage, with each researcher inducing the cellular damage with different injurious agent.…”

Section: Discussionsupporting

confidence: 90%

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Asante

Effah-Yeboah

Barnes

et al. 2016

Journal of Diabetes Research

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The young leaves of Vernonia amygdalina are often utilized as vegetable and for medicinal purpose compared to the old leaves. This study was designed to evaluate and compare the antidiabetic effects between ethanolic leaf extracts of old and young V. amygdalina on streptozotocin (STZ) induced diabetic rat for four weeks. Preliminary screening of both young and old ethanolic extracts revealed the presence of the same phytochemicals except flavonoids which was only present in the old V. amygdalina. Difference in antioxidant power between the young and old leaf extracts was statistically significant (p < 0.05). Both leaf extracts produced a significant (p < 0.05) antihyperglycaemic effect. Also results from treated rats revealed increasing effect in some haematological parameters. Similarly, the higher dose (300 mg/kg) of both extracts significantly (p < 0.05) reduced serum ALT, AST, and ALP levels as compared to the diabetic control rats. Results also showed significant (p < 0.05) decrease in LDL-C and VLDL-C in the extract-treated rats with a corresponding increase in HDL-C, as compared to the diabetic control rats. Moreover histopathological analysis revealed ameliorative effect of pathological insults induced by the STZ in the pancreas, liver, and spleen, most significantly the regeneration of the beta cells of the islets of Langerhans in treated rats.

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Section: Discussionsupporting

confidence: 90%

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Asante

Effah-Yeboah

Barnes

et al. 2016

Journal of Diabetes Research

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“…All dosages of quercetin decreased AST levels in the serum of arthritic rats, demonstrating the hepatoprotective potential effect of this flavonoid. This effect has been verified in other studies, and it is suggested to be due to the antioxidant capacity of quercetin through the elimination of reactive oxygen species, inhibition of lipoxygenase and cyclooxygenase, and stabilization of cell membranes …”

Section: Discussionsupporting

confidence: 68%

“…This effect has been verified in other studies, [50][51][52] and it is suggested to be due to the antioxidant capacity of quercetin through the elimination of reactive oxygen species, 53,54 inhibition of lipoxygenase and cyclooxygenase, and stabilization of cell membranes. 53,55,56 In the present study, we observed increased ROS and TBARS levels in the untreated arthritic group, which may be owing to the production of ROS as a result of inflammation, leading to the destruction of cartilage and bone, neutrophil degranulation, and the release of various potentially harmful enzymes. 18,57 Oxidative stress can induce the peroxidation of membrane lipids, which may result in inactivation of membrane-bound receptors or enzymes with a consequential increase in tissue permeability and damage to normal cellular function.…”

Section: Discussionsupporting

confidence: 53%

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Saccol

Silveira

Manzoni

et al. 2019

J of Cellular Biochemistry

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Rheumatoid arthritis is a highly debilitating inflammatory autoimmune disease which is characterized by joint destruction. The present study sought to investigate the effect of quercetin in rats with complete Freund's adjuvant‐induced arthritis. Animals were divided into control/saline, control/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg) arthritis/saline, and arthritis/quercetin (5 mg/kg, 25 mg/kg, and 50 mg/kg); the treatments were administered for 45 days. Biochemical, oxidative stress, genotoxicity, and cytotoxicity parameters were evaluated. All doses of quercetin reduced the levels of aspartate aminotransferase, thiobarbituric acid‐reactive substances, and reactive oxygen species; however, only treatment with 25 or 50 mg/kg increased catalase activity. Total thiol and reduced glutathione levels were not significantly affected by the induction nor by the treatments. Genotoxicity assessed by DNA damage, and cytotoxicity through picogreen assay, decreased after treatments with quercetin. Our results present evidence of the antioxidant, cytoprotective, genoprotective and hepatoprotective, and effects of quercetin, demonstrating its potential as a candidate for coadjuvant therapy.

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“…Several studies have found polyphenols to interact with cellular defense systems such as phases I (mainly the CYP450 complex enzymes) and II (e.g., glutathione transferases and glucuronyl transferases) detoxifying enzymes [40]. It is well known that plant sources containing flavonoids (e.g., saponarin) have membrane-stabilizing activity, hepatoprotective, antioxidant, and CYP2E1 inhibitory effect [41]. It is widely believed that the main component of paracetamol toxicity is CYP2E1-mediated metabolism of paracetamol to NAPQI [42].…”

Section: Discussionmentioning

confidence: 99%

“…We observed that either administered alone or with paracetamol after a 7-day pretreatment period, saponarin decreased the total level of cytochrome P450, as well the activity of AH, a marker enzyme for CYP2E1 [44], and EMND, a marker enzyme for CYP3A4 [45]. According to Kumarappan et al [41], this is probably due to direct inactivation or inhibition of enzyme expression. On the basis of our results we would speculate that acting as an inhibitor of drug metabolizing enzyme system saponarin decreased the formation of toxic metabolite of paracetamol, NAPQI, and thus decreased its toxicity.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Effects of Saponarin, Isolated fromGypsophila trichotomaWend. on Paracetamol-Induced Liver Damage in Rats

Simeonova

Vitcheva

Kondeva-Burdina

et al. 2013

BioMed Research International

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The hepatoprotective potential of saponarin, isolated from Gypsophila trichotoma, was evaluated in vitro/in vivo using a hepatotoxicity model of paracetamol-induced liver injury. In freshly isolated rat hepatocytes, paracetamol (100 μmol) led to a significant decrease in cell viability, increased LDH leakage, decreased levels of cellular GSH, and elevated MDA quantity. Saponarin (60–0.006 μg/mL) preincubation, however, significantly ameliorated paracetamol-induced hepatotoxicity in a concentration-dependent manner. The beneficial effect of saponarin was also observed in vivo. Rats were challenged with paracetamol alone (600 mg/kg, i.p.) and after 7-day pretreatment with saponarin (80 mg/kg, oral gavage). Paracetamol toxicity was evidenced by increase in MDA quantity and decrease in cell GSH levels and antioxidant defence system. No changes in phase I enzyme activities of AH and EMND and cytochrome P 450 quantity were detected. Saponarin pretreatment resulted in significant increase in cell antioxidant defence system and GSH levels and decrease in lipid peroxidation. The biochemical changes are in good correlation with the histopathological data. Protective activity of saponarin was similar to the activity of positive control silymarin. On the basis of these results, it can be concluded that saponarin exerts antioxidant and hepatoprotective activity against paracetamol liver injury in vitro/in vivo.

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Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen

Cited by 23 publications

References 27 publications

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts ofVernonia amygdalina: A Comparative Study

Antioxidant, hepatoprotective, genoprotective, and cytoprotective effects of quercetin in a murine model of arthritis

Hepatoprotective and Antioxidant Effects of Saponarin, Isolated fromGypsophila trichotomaWend. on Paracetamol-Induced Liver Damage in Rats

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