“…The absence of IL-10 greatly influenced the generation of Th1 cells, as has been observed previously. In mice, the absence of IL-10 or the blockade of its cognate receptor enhances the protective immune response to Leishmania donovani, Plasmodium spp., Listeria monocytogenes, Coccidioides immitis, Mycobacterium spp., and H. capsulatum (10,13,20,23,24,28). Despite the pronounced skewing of the immune response to a Th1 phenotype, neither polyclonal nor monoclonal cells from IL- were examined or whether the examination was restricted to V8.1/8.2 ϩ cells.…”