Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Busari, Abdulwasiu Adeniyi; Adejare, Abdullahi A.; Shodipe, Abiodun F.; Oduniyi, Oludaisi A.; Ismail-Badmus, Khadijah B.; Oreagba, Ibrahim Adekunle

doi:10.1055/a-0626-7003

Cited by 14 publications

(7 citation statements)

References 37 publications

(34 reference statements)

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“…Meanwhile treating cisplatinadministrated rats with TQ, Vit E and their combination in G3, G4 and G5, respectively ameliorated the histopathological damage of the renal tissues and nearly restored them to the normal. This result is consistent with that obtained by Busari et al [29]. However, we also found a synergistic effect of TQ and Vit E in ameliorating cisplatin induced nephropathy.…”

Section: Discussionsupporting

confidence: 94%

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Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

Alghamdi

Al‐Seeni

Ghoneim

2020

Clinical Nutrition Experimental

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Section: Discussionsupporting

confidence: 94%

“…However, we also found a synergistic effect of TQ and Vit E in ameliorating cisplatin induced nephropathy. This may be due to direct application of thymoquinone instead of nigella sativa that was previously used [29].…”

Section: Discussionmentioning

confidence: 99%

Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

Alghamdi

Al‐Seeni

Ghoneim

2020

Clinical Nutrition Experimental

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“…Protective effect against cisplatin-induced renal toxicity and oxidative stress in wistar rats 100-200 mg/kg of body weight for 5 days [118] Ocimum basilicum L.…”

Section: Ethanol Extract Ratsmentioning

confidence: 99%

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Bencheikh

Elbouzidi

Kharchoufa

et al. 2021

Plants

153

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Kidney disease is one of the most common health problems and kidney failure can be fatal. It is one of the health disorders associated with extreme pain and discomfort in patients. In developing countries, such as Morocco where socioeconomic and sanitary conditions are precarious, medicinal plants are considered the primary source of medication. In the present work an ethnobotanical survey was conducted in a remote area of North-Eastern Morocco and we focused on (1) establishing a record of medicinal plants used traditionally by local people to treat kidney diseases and (2) correlate the obtained ethnomedical use with well-studied pharmacological evidence. From February 2018 to January2020, information was gathered from 488 informants using semi-structured questionnaires. The data were analyzed using three quantitative indices: The use value (UV), family use value (FUV), and informant consensus factor (ICF). A total of 121 plant species belonging to 57 botanical families were identified to treat kidney diseases. The families most represented were Asteraceae (14 species), followed by Lamiaceae (12 species) and Apiaceae (10 species). The most commonly used plant parts were leaves, followed by the whole plant and they were most commonly prepared by decoction and infusion. The highest value of the (UV) index was attributed to Herniaria hirsuta L. (UV = 0.16), and the highest family use value (FUV) was assigned to Caryophyllaceae with (FUV = 0.163). Regarding the informant consensus factor (ICF), this index’s highest values were recorded for kidney stones (ICF = 0.72). The use of 45% of the selected plants were validated based on literature review. This study helped document and preserve crucial traditional plant knowledge of 121 plant species used to treat kidney problems that can be used in the search for new biologically active compounds through more upcoming pharmacological studies.

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“…In their study, they showed that the combination of NS and Vit E, despite their antioxidant effects, did not show significant additive effects. 16 On the contrary, the observed result of the combination was less than the effect observed with each agent individually. NS may act differently and be pro-oxidant rather than an antioxidant in particular cells or organs.…”

Section: Discussionmentioning

confidence: 93%

Effect of Nigella Sativa (Black Cumin), Vitamin E and their Combination on Metoprolol Induced Hepatotoxicity in Rabbits

Hussein,

Ahmed

2021

Indian Journal of Forensic Medicine & Toxicology

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Background: Metoprolol (MET) is a selective Beta-1 blocker. It is metabolized in the liver. Unlike most Betablockers, Metoprolol is unique in causing liver toxicity, which is infrequent, ranging from raised liver enzymes to severe liver damage. Aim: hepatotoxicity was induced in rabbits, and protective effects of Nigella sativa (NS), Vitamin E (Vit E), and a combination of Nigella sativa + Vitamin E were investigated on Metoprolol-induced hepatotoxicity.Methods: 36 male rabbits were divided into six groups and treated as follow: Metoprolol (20mg/kg), Nigella sativa (2ml/kg), control group, Metoprolol + Nigella sativa, Metoprolol + Vitamin E ( 175mg/ kg/day), Metoprolol + Nigella sativa + Vitamin E. Treatments were given orally for two weeks. Liver enzymes, malondialdehyde, glutathione, and interleukins (IL-6, IL-10) were measured in serum and liver homogenates. Histopathological examinations were done for two animals in each group.Results: Elevated liver enzymes and histopathological changes were seen in all Metoprolol-treated animals. Nigella sativa, Vitamin E, and Nigella sativa + Vitamin E reduced Metoprolol-induced rise in liver enzymes. Metoprolol increased malondialdehyde concentration in serum and liver homogenate. Treatment with Nigella sativa, Nigella sativa + Vitamin E insignificantly decreased these levels. Neither Metoprolol nor Metoprolol and Nigella sativa, Vitamin E, and their combination changed the levels of IL-6 or IL-10. Conclusion:Metoprolol increased liver enzymes, and treatment with Nigella sativa, Vitamin E, and Nigella sativa + Vitamin E significantly modified rise in liver enzymes. Metoprolol and other treatments had little effect on IL-6 or IL-10.

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Protective but Non-Synergistic Effects of Nigella Sativa and Vitamin E against Cisplatin-Induced Renal Toxicity and Oxidative Stress in Wistar Rats

Abstract: These results suggest that even though pre-administration of the two agents protect against renal toxicity and oxidative stress, the effects are however not collaborative.

Cited by 14 publications

References 37 publications

Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

Potential synergistic antioxidant effect of thymoquinone and vitamin E on cisplatin-induced acute nephropathy in rats

Inventory of Medicinal Plants Used Traditionally to Manage Kidney Diseases in North-Eastern Morocco: Ethnobotanical Fieldwork and Pharmacological Evidence

Effect of Nigella Sativa (Black Cumin), Vitamin E and their Combination on Metoprolol Induced Hepatotoxicity in Rabbits

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