Protective Effect of 1,25-Dihydroxy Vitamin D3 on Pepsin–Trypsin-Resistant Gliadin-Induced Tight Junction Injuries

Dong, Shouquan; Singh, Tikka Prabhjot; Wei, Xin; Yao, Huang; Wang, Hongling

doi:10.1007/s10620-017-4738-0

Cited by 30 publications

(25 citation statements)

References 43 publications

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“…Increases of intraepithelial lymphocytes and epithelial cell proliferations with crypt hyperplasia, as well as reduced enterocyte differentiation, characterize pathological lesions. In addition, CD4+ cells participate to the activation of B cells throughout Th2, resulting in the production of antibodies to gluten and transglutaminase [18,[38][39][40][41].…”

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

“…Although the main external trigger is gluten, which is able to activate both innate and adaptive immune systems, the intestinal barrier plays a key role. Indeed, in susceptible individuals, an early disruption of the gut barrier will result in an increased permeability that could precede the onset of immune events induced by gluten [18,38].…”

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

“…Its dynamic interaction with environmental factors such as pollutants, microorganisms and other materials are at the base of its crucial role. Its functionality depends on several factors, including epithelial layer integrity, gut-associated lymphoid tissue and intestinal microbiota homeostasis [18,38,42].…”

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

“…Injuries of TJs and consequent junction disassembly are considered initial processes that lead to the entry of gliadin peptide fragments and subsequent immune response activation. In this regard, increased intestinal permeability appears to be an early biologic change that precedes the onset of autoimmune diseases, including CD [38,43,44].…”

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

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Possible Role of Vitamin D in Celiac Disease Onset

2020

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Beside skeletal system maintenance and protection, possible extra-calcium roles of vitamin D have been recently described. In particular, studies have investigated possible roles of vitamin D as a key modulator of inflammation and immune mechanisms and of the intestinal mucosa barrier. In this regard, vitamin D has been considered as a factor that affects different conditions such as immune-mediated diseases. The new emerging role of vitamin D and its involvement in immune modulation has led it to be considered as a possible key factor involved in celiac disease (CD) onset. CD is a chronic immune-mediated enteropathy of the small intestine that is triggered by dietary gluten protein exposure in individuals who are genetically predisposed. However, along with gluten, other environmental factors are also involved in CD onset. The renewed interest in a molecule that offers great possibilities for new roles has led to an increase in studies, although there remains a lack of studies aimed at contextualizing the role of vitamin D on CD. This review aims to define the possible role of vitamin D in CD onset as it is presently understood, taking into account potential links among vitamin D, the immune system and CD.

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Section: Vitamin D and Immune Systemmentioning

confidence: 99%

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

Section: Vitamin D and Immune Systemmentioning

confidence: 99%

See 2 more Smart Citations

Possible Role of Vitamin D in Celiac Disease Onset

2020

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“…In this issue of Digestive Disease and Sciences, Dong et al published an innovative paper that demonstrated the beneficial effects of the vitamin D metabolite 1,25-dihydroxycholecalciferol (VD3) or calcitriol, a health-promoting molecule [9]. VD3 is thought to be the most active metabolite of vitamin D in humans, a modulator of calcium homeostasis and regulator of electrolytes and blood pressure.…”

mentioning

confidence: 99%