Protective effect of aronia melanocarpa fruit juice in a model of cisplatin-induced cytotoxicity in vitro

Chokeberries (Aronia melanocarpa) and Their Products as a Possible Means for the Prevention and Treatment of Noncommunicable Diseases and Unfavorable Health Effects Due to Exposure to Xenobiotics

“…The mechanisms of antimutagenic and anticarcinogenic action of chokeberry products as well as their cytoprotective influence on healthy cells obtained from patients during and after chemotherapy with these products are described below. Valcheva‐Kuzmanova and others () have confirmed the cytoprotective effect of juice made from A. melanocarpa fruit in the human embryonic kidney cell line HEK293T treated with cisplatin. Aronox at a concentration of 50 μg/mL decreased the level of oxidative stress in platelets ex vivo without neoplastic changes obtained from patients with invasive breast cancer during chemotherapy (Kędzierska and others ), and it significantly reduced ex vivo the intensity of oxidative stress and changes of hemostasis in the plasma of breast cancer patients after surgery and the different phases of chemotherapy (Kędzierska and others ).…”

“…Moreover, based on the available data, it can be concluded that the consumption of chokeberry products may be effective for the protection against side effects of drugs used in chemotherapy (such as cisplatin). The protective antioxidative effect of the extract and juice from chokeberries on healthy cells was noticed during and after chemotherapy (Olas and others ; Kędzierska and others , ,b; Valcheva‐Kuzmanova and others ). The mechanisms of antimutagenic and anticarcinogenic action of chokeberry products as well as their cytoprotective influence on healthy cells obtained from patients during and after chemotherapy with these products are described below.…”

“…Until now, the protective effects of A. melanocarpa berries and products made from them have been described in regard to heavy metals, such as Cd (Brzóska and others , ,b, ,b; Kowalczyk ; Roszczenko and others ) and Pb (Kowalczyk and others , ), ethanol (Niedworok and others ; Matsumoto and others ; Valcheva‐Kuzmanova and others , ), carbon tetrachloride (CCl 4 ; Valcheva‐Kuzmanova and others ), N‐nitrosocompounds (Atanasova‐Goranova and others ; Kujawska and others ), PAH (benzo‐[a]‐pyrene and 7,12‐dimethylbenz[a]anthracene; Gąsiorowski and others ; Szaefer and others ), sulphide‐2‐chloroethyl‐3‐chloropropyl (Kowalczyk and others ), 2‐amino fluorine (Gąsiorowski and others ), sulfur mustard (Kowalczyk and others ), and some medicines (Niedworok and others ; Valcheva‐Kuzmanova and others , , ; Dietrich‐Muszalska and others ; Figure ). Moreover, A. melanocarpa extract has been reported to protect from the harmfulness of tobacco smoke (Balansky and others ).…”

“…Chokeberries should not be confused with chokecherries, which are a different fruit and belong to the Genus Prunus . The results of some studies conducted in animal models indicate that chokeberries seem to be a possible means to counteract the unfavorable health effects of exposure to some xenobiotics (Niedworok and others , ; Kowalczyk and others ,b; Matsumoto and others ; Valcheva‐Kuzmanova and others , ,b; Szaefer and others ; Balansky and others ; Roszczenko and others ; Dietrich‐Muszalska and others ; Navaneethan and Rasool ; Brzóska and others ,b, ,b; Hao and others ). This issue needs special attention because humans in their lifetime are exposed to more and more numerous chemical substances dangerous to their health and some of them contribute to the development of noncommunicable diseases: heart and circulatory diseases, cancers, diabetes, obesity and overweight, digestive system disorders, colds, some skin troubles as well as disorders of the reproductive system and nervous system (Draz and others ; Hsu and others ; Ferraro and others ; Kalariya and others ; Shargorodsky and others ; Bakulski and others ; Choi and others ; Chen and others ; Liu and others ; Moitra and others ; Tellez‐Plaza and others ; Åkesson and others ; Sommar and others ; Wallin and others ; Wu and others ).…”

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“…We evaluated the cells' proliferation by MTT assay which MTT is a positively charged tertrazolium salt and is converted into purple formazan product after entry into actively metabolizing viable cells 12 .…”